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A kind of production method of rubber piston for prefilled syringe

The technology of a rubber piston and a production method, which is applied to the field of rubber parts for pre-filled syringes, can solve the problems of high pollution probability in production links, low utilization rate of rubber materials, large waste of leftover materials, etc., and achieves high production efficiency and high output rate. , the effect of less process

Active Publication Date: 2019-11-15
郑州翱翔医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The traditional production process has many procedures, long process, high probability of pollution in the production process, large waste of vulcanized leftover materials, and low utilization rate of rubber materials.

Method used

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  • A kind of production method of rubber piston for prefilled syringe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A 1ml elongated prefilled syringe with a bromobutyl rubber plunger, produced as follows:

[0025] A. Ingredients: Accurately weigh 100 parts by weight of bromobutyl rubber BIIR2211, 5 parts by weight of precipitated silica, 70 parts by weight of calcined kaolin, 1.0 parts by weight of insoluble sulfur, 3.0 parts by weight of zinc oxide, 1.0 parts by weight of stearic acid, 4.0 parts by weight of magnesium oxide, 10 parts by weight of low molecular weight polyethylene wax, 4 parts by weight of titanium dioxide, 0.8 parts by weight of carbon black, for subsequent use;

[0026] B. Internal mixing: Mix the weighed raw materials evenly with a powerful pressurized internal mixer with a capacity of 75 liters, and operate according to the appropriate internal mixing process. The internal mixing cycle is 8-15 minutes, and the actual internal mixing rubber material The temperature is 100-120°C, and the mixed rubber is prepared for use;

[0027] C. Open mixing and stamping: on th...

Embodiment 2

[0035] A 1ml standard prefilled syringe for chlorobutyl rubber plunger, the production steps are as follows:

[0036] A. Ingredients: Accurately weigh 100 parts by weight of chlorinated butyl rubber CIIR1066, 30 parts by weight of talcum powder, 50 parts by weight of calcined kaolin, 2.0 parts by weight of alkyl phenolic vulcanized resin, 5.0 parts by weight of zinc oxide, 1.0 parts by weight of stearic acid, 1.0 parts by weight of magnesium oxide, 5 parts by weight of polyisobutylene, 3 parts by weight of titanium dioxide, 0.6 parts by weight of carbon black, for subsequent use;

[0037] B. Internal mixing: Mix the weighed raw materials evenly with a powerful pressurized internal mixer with a capacity of 75 liters, and operate according to the appropriate internal mixing process. The internal mixing cycle is 8-12 minutes, and the actual internal mixing rubber material The temperature is 100-120°C, and the mixed rubber is prepared for use;

[0038]C. Open mixing and stamping:...

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PUM

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Abstract

The invention discloses a production method for a rubber piston for a pre-potting injector. The method comprises the first step of burdening, the second step of rubber mixing, the third step of precise pre-forming, the fourth step of die pressing vulcanization forming, the fifth step of freezing, punching and edge removing, and the sixth step of cleaning packaging, wherein in the third step, a precise pre-forming machine is adopted for placing a rubber compound in the second step into the precise pre-forming machine, then, small columnar rubber particles are obtained through accurate cutting according to the specification and weight of the rubber piston needing to be produced and used for the pre-potting injector, and treatment is conducted through a cooling vibration screen. The professional precise pre-forming machine is adopted in the production method, automatic and precise weighing is conducted, few procedures are adopted, the production efficiency is high, the size is precise, the yield of vulcanized products is higher, few waste edges are generated, and waste is greatly reduced. Through the vulcanization die optimization design, a freezing edge trimming machine can be adopted for conducting edge trimming on the rubber piston. Operation is simple, the automation degree is high, the situation that due to thick flanges of a traditional rubber piston, a method for punching through a mechanical punching machine must be adopted is avoided, little pollution is generated, and the edge trimming safety coefficient is high.

Description

technical field [0001] The invention belongs to the field of rubber fittings for prefilled syringes, and in particular relates to a production method of a rubber piston for prefilled syringes. Background technique [0002] At present, as an advanced form of pharmaceutical packaging, prefilled syringes are used in a wider range of applications. It has two functions of packaging and storing medicines and medical injections at the same time. It is mainly used in the packaging of biological medicines, genetic medicines and immunological medicines with high added value, as well as the packaging of household medicines for treating chronic diseases, so as to facilitate patients' self-injection. [0003] The quality of the rubber piston used with the prefilled syringe is closely related to the quality of the prefilled syringe. Therefore, for the research and development of rubber pistons for prefilled syringes, scientific design and selection of rubber formulas, and the use of adva...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C35/02B29C37/02C08L23/28C08K13/02C08K3/36C08K3/34C08K3/06C08K3/22C08K5/09
CPCB29C35/02B29C37/02C08K2003/2296C08L23/283C08L23/06C08K13/02C08K3/36C08K3/346C08K3/06C08K3/22C08L23/22C08K3/34C08K5/09
Inventor 马东风刘海洪杨明真李向阳
Owner 郑州翱翔医药科技股份有限公司
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