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Application of Fibulin-3 taken as target point to prepare medicine for preventing and treating psoriasis

A technology of fibulin-3, 1. fibulin-3 is applied in the application field of preparation and prevention of psoriasis, can solve problems such as poor prognosis of tumors and vascular proliferation, and achieve the effects of improving erythema and clear intervention targets.

Active Publication Date: 2018-02-16
XI AN JIAOTONG UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been many biological studies on the role of Fibulin-3 in the development of tumors. It is reported that the methylation of the EFEMP1 gene promoter can reduce the expression of Fibulin-3, thereby leading to the proliferation of blood vessels in tumor tissues and poor prognosis of tumors.

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  • Application of Fibulin-3 taken as target point to prepare medicine for preventing and treating psoriasis
  • Application of Fibulin-3 taken as target point to prepare medicine for preventing and treating psoriasis
  • Application of Fibulin-3 taken as target point to prepare medicine for preventing and treating psoriasis

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0026] The present invention found that the expression of Fibulin-3 was increased in the skin lesions of patients with psoriasis and in the skin lesions of psoriasis mouse models induced by imiquimod. The expression of -3 increases; these suggest that Fibulin-3 is positively correlated with the development of psoriasis, and the present invention will be further described in detail below.

[0027] 1. Establishment of psoriasis mouse model

[0028] BALB / c female mice at the age of 6-7 weeks were purchased. Before the experiment, the mice were anesthetized by intraperitoneal injection of 5% chloral hydrate (0.1ml / 10g). Cage feeding. Apply 50 mg of 5% imiquimod cream to the back of the mice every day, and massage gently with one finger 30 times for 7 consecutive days.

[0029] 2. Treatment wit...

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Abstract

The invention discloses an application of Fibulin-3 taken as a target point to prepare a medicine for preventing and treating psoriasis. The medicine takes Fibulin-3 as a medicinal target point in a gene level and / or a protein level. Fibulin-3 is positively correlated with development of psoriasis. A proper concentration of a Fibulin-3 antibody is adopted to treat an imiquimod-induced psoriasis mouse model, and erythema, scale and the lesion thickness of the skin are improved. Expression of vascular endothelial cells (VEGF) is reduced, and proliferation and migration of vascular endothelial cells are reduced to prevent development of psoriasis and promote skin recovery. Compared with other medicines for treating psoriasis, the Fibulin-3 antibody can more clearly interfere into a target point, aiming at changing pathology of circuity and tensile strength of dermal superficial blood vessels and proliferation of blood vessels in the early stage of psoriasis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of Fibulin-3 in the preparation and prevention of psoriasis. Background technique [0002] Psoriasis is a chronic inflammatory skin disease with a high incidence and a long course. It mainly targets young and middle-aged people. The disease affects about 1% to 3% of the world's population. In recent years, with changes in climate, environment, diet, etc., the incidence rate is still rising. In addition to the economic burden, patients with serious illnesses also cause the loss of social labor force. Therefore, psoriasis has a great negative impact on patients' physical and mental health and daily life. The main pathological changes of psoriasis are the excessive proliferation and abnormal differentiation of epidermal keratinocytes, the infiltration of inflammatory cells in the epidermis, and the tortuous hyperplasia of blood vessels in the superficial dermis. B...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68A61K45/00A61K39/395A61P17/06
CPCA61K45/00A61K2039/505C07K16/22C12Q1/6883C12Q2600/106G01N33/6863G01N2800/205
Inventor 郑焱王芯屈小燕杨珮雯景慧玲
Owner XI AN JIAOTONG UNIV
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