Whole blood and plasma separation system and method thereof

Abstract

The invention provides a whole blood and plasma separation system and a method thereof. The system includes a first blood separation device and a second blood separation device. The first blood separation device includes a blood collection unit and at least one first microfluidic chip. A micropillar array is arranged inside the microfluidic chip. The minimum column spacing of the microcolumn arrayis greater than or equal to diameter of red blood cells. The second blood separation device includes a second microfluidic chip, a plasma recovery unit and a waste fluid recovery unit. The second microfluidic chip is provided with a microfluidic channel. The blood collection unit, at least one first micro-fluidic chip and the second micro-fluidic chip are successively arranged in the blood flow direction and are sequentially connected end to end through a fluid pipe. The plasma recovery unit is connected to a plasma outlet of the microfluidic channel through a fluid pipe. The waste fluid recovery unit is connected to a waste fluid outlet of the microfluidic channel through a fluid pipe. According to the invention, rapid separation of blood cells and platelets in a very small amount of blood samples can be achieved, and the detection efficiency of blood samples is raised.

Description

technical field [0001] The embodiments of the present invention belong to the technical field of biomedicine, and in particular relate to a whole blood plasma separation system and method. Background technique [0002] Blood is composed of blood cells and plasma. Blood is closely related to tissues and organs of various systems in the body. Under normal physiological conditions, the quality and quantity of various components in blood directly reflect the normal metabolism of the body and the internal and external environment. In pathological conditions, blood can not only directly reflect the diseases of the human hematopoietic system, but also directly or indirectly reflect the lesions of the whole body or local tissues and organs. Therefore, blood can not only be used as the main basis for the diagnosis, differential diagnosis, curative effect observation and prognosis judgment of primary hematopoietic system diseases, but also provide important information for the diagnos...

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Problems solved by technology

[0003] However, in the vast majority of blood clinical diagnosis and basic research processes, large centrifuges are usually used to separate plasma and blood cells, which requires a large amount of blood from patients, and the centrifuges are large in size and complex in structure. Directly connected to blood testing equipment, so that blood separation and blood testing need to be carried out independently, which is likely to cause sample contamination and low testing efficiency, which cannot meet the needs of safe and fast blood testing

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