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A method for determining the fingerprint of Naoxueshu preparation

The technology of fingerprint spectrum and determination method is applied in the field of determination of cerebral and blood sparse fingerprints of traditional Chinese medicine preparations, which can solve the problems of not reflecting the overall characteristics of traditional Chinese medicine compound preparations, and the quality of medicines is not comprehensive. The effect of quality and efficacy assurance

Active Publication Date: 2020-09-29
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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AI Technical Summary

Problems solved by technology

However, Naoxueshu Oral Liquid is a compound preparation, and it is obviously not comprehensive to control the quality of its drug simply by measuring the quantity of an index component, nor can it reflect the overall characteristics of the traditional Chinese medicine compound preparation.

Method used

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  • A method for determining the fingerprint of Naoxueshu preparation
  • A method for determining the fingerprint of Naoxueshu preparation
  • A method for determining the fingerprint of Naoxueshu preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1, assay method and methodology verification

[0059] (1) Preparation of the test solution: take 12 batches of Naoxueshu Oral Liquid, accurately measure 1.0ml of Naoxueshu Oral Liquid in each batch into a 10ml volumetric flask, add methanol to the volume, ultrasonically extract for 10 minutes, and return to At room temperature, pass through a 0.45 μm microporous membrane, and take the subsequent filtrate to obtain the test solution.

[0060] (2) Preparation of reference substance solution:

[0061] Accurately weigh 7.50 mg of astragaloside IV standard substance, put it in a 10 mL volumetric flask, add methanol to dissolve and dilute to the mark to obtain a reference solution with a concentration of 0.75 mg / mL;

[0062] Accurately weigh 0.0285g of hirudin standard substance, put it in a 10mL volumetric flask, add methanol to dissolve and dilute to the mark to obtain a reference substance solution with a concentration of 2.85mg / mL;

[0063] Accurately weigh 4...

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Abstract

The invention relates to a detecting method of a pharmaceutical preparation, in particular to a building method of a traditional Chinese medicine preparation cerebral vessel opening oral liquid fingerprint spectrum. An efficient liquid chromatography is mainly used for detection; mobile phases are acetonitrile and 0.1-percent phosphoric acid water; the mobile phase A is 0.1-percent phosphoric acidwater; the mobile phase B is acetonitrile; the detection wavelength is 223nm; the column temperature is 30 DEG C; the sampling quantity is 10mul; all ingredients are detected within 90min.

Description

technical field [0001] The invention relates to a detection method of a medicinal preparation, in particular to a detection method of a Chinese medicine preparation cerebral blood thinning fingerprint. Background technique [0002] Cerebrovascular disease is one of the three major diseases that endanger human health in the world today. It is a frequently-occurring disease among middle-aged and elderly people with a high mortality rate. Cerebrovascular disease accounts for the second cause of death in my country. According to domestic reports, the mortality rate of cerebral hemorrhage is 38-43%. About 50%-70% of the survivors have severe sequelae and cannot take care of themselves. Not only the patients suffer great pain, but also bring burdens to families and society. [0003] Traditional Chinese medicine has its advantages in the treatment of cerebrovascular diseases. For example, the traditional Chinese medicine Naoxueshu Oral Liquid has been marketed. Its formula and proc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/86G01N30/74G01N30/06
CPCG01N30/06G01N30/74G01N30/8686
Inventor 周万辉曾英姿王冬梅于洪亮赵磊程世娟刘春蕾高燕高阳
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD