Composite medicinal preparation and application to preparation of medicines for treating hyperglycemia and hyperlipidemia

A pharmaceutical preparation and compound technology, applied in the field of medicine, can solve problems such as unsatisfactory therapeutic effect, achieve the effect of reducing the content and improving the therapeutic effect

Inactive Publication Date: 2018-03-13
GUILIN HAOXIN TECH SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to age factors, pathological factors, eating habits and other reasons, most diabetic patients do not use drugs to maintain normal or near-normal levels of blood sugar and blood lipids. Although there are some reports about drugs that lower blood sugar and blood lipids, but The treatment effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Formula composition: in parts by weight, 25 parts of anseltrapib, 20 parts of oxymepyrazine, 15 parts of rosiglitazone and 30 parts of fenofibrate, 100 parts of starch, 100 parts of microcrystalline cellulose, carboxymethyl 70 parts of sodium starch, 2-5 parts of magnesium stearate.

[0017] Coating Solution Prescription: Povidone K 30 aqueous solution.

[0018] The preparation method of tablet: take by weighing prescription quantity of anseltrapib, oxymepyrazine, sodium carboxymethyl starch, microcrystalline cellulose and mix, then mix with prescription quantity of rosiglitazone and fenofibrate, Povidone K 30 The aqueous solution is used as a binder to make a soft material, granulated; dried;

Embodiment 2

[0020] Formula composition: in parts by weight, 35 parts of anseltrapib, 24 parts of oxymepyrazine, 20 parts of rosiglitazone and 40 parts of fenofibrate, 100 parts of starch, 100 parts of microcrystalline cellulose, carboxymethyl 70 parts of sodium starch, 2-5 parts of magnesium stearate.

[0021] Coating Solution Prescription: Povidone K 30 aqueous solution.

[0022] The preparation method of tablet: take by weighing prescription quantity of anseltrapib, oxymepyrazine, sodium carboxymethyl starch, microcrystalline cellulose and mix, then mix with prescription quantity of rosiglitazone and fenofibrate, Povidone K 30 The aqueous solution is used as a binder to make a soft material, granulated; dried;

Embodiment 3

[0024] Formula composition: in parts by weight, 25 parts of anseltrapib, 20 parts of oxymepyrazine, 15 parts of rosiglitazone and 30 parts of fenofibrate, 100 parts of starch, 100 parts of microcrystalline cellulose, carboxymethyl 70 parts of sodium starch, 2-5 parts of magnesium stearate.

[0025] Coating Solution Prescription: Povidone K 30 aqueous solution.

[0026] The preparation method of tablet: take by weighing prescription quantity of anseltrapib, oxymepyrazine, sodium carboxymethyl starch, microcrystalline cellulose and mix, then mix with prescription quantity of rosiglitazone and fenofibrate, Povidone K 30 The aqueous solution is used as a binder to make a soft material, granulated; dried;

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PUM

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Abstract

The invention relates to a composite medicinal preparation and application to preparation of medicines for treating hyperglycemia and hyperlipidemia. The composite medicinal preparation comprises thefollowing effective active components: anacetrapib, olbetam, rosiglitazone and fenofibrate. By adopting the composite medicinal preparation provided by the invention, not only is the defect that in the prior art a medicine for reducing blood sugar and blood fat is poor in treatment effect effectively solved, but also the functions of different components of the combined medicines are not simply overlapped, but a synergistic effect is achieved. By adopting the composite medicinal preparation provided by the invention, not only is the treatment effect on diabetes improved, but also a relativelygood effect of reducing the content of triglyceride in human bodies is also achieved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound pharmaceutical preparation and its application in the preparation of medicines for treating hyperglycemia and hyperlipidemia. Background technique [0002] Diabetes is a group of metabolic disorders characterized by elevated blood glucose levels due to relative or absolute insufficiency of insulin in the body, including sugar, fat, and protein metabolic disorders and the resulting tissue and organ dysfunction; persistent high blood sugar is a basic biochemical characteristics, but accompanied by hyperlipidemia and other metabolic disorders. Hyperlipidemia is one of the important risk factors of arteriosclerosis and coronary heart disease, and is the pathological basis of cardiovascular and cerebrovascular diseases. Most diabetic patients are accompanied by hyperlipidemia in varying degrees. If the metabolic disorder cannot be corrected in time and the blood sugar and...

Claims

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Application Information

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IPC IPC(8): A61K31/421A61K31/4965A61K31/4439A61K31/216A61P3/10A61P3/06A61P9/10
CPCA61K31/421A61K31/216A61K31/4439A61K31/4965A61K2300/00
Inventor 钟传新王君
Owner GUILIN HAOXIN TECH SERVICE
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