Optical fiber dynamic light scattering detection device for high-concentration particle swarms

Abstract

The invention discloses an optical fiber dynamic light scattering detection device for high-concentration particle swarms, and belongs to the field of photoelectric detection. The optical fiber dynamic light scattering detection device comprises a laser device, an optical fiber coupler, a transmitting optical fiber, a receiving optical fiber, a micro-fluidic chip, a photoelectric detector and a digital correlator. The micro-fluidic chip is provided with a micro-channel, the micro-channel is used as a sample pool, the laser device is used for transmitting coherent light, the transmitting optical fiber is connected with a laser source by the optical fiber coupler, the coherent light can be coupled by the optical coupler to be transmitted into the sample pool via the transmitting optical fiber, can be transmitted through the high-concentration particle swarms, with the to-be-measured particle sizes, in the sample pool and then is scattered, scattered light can be transmitted through the receiving optical fiber and can be transmitted into the photoelectric detector via the optical fiber coupler, and the digital correlator is connected with the photoelectric detector and is used for acquiring light intensity autocorrelation functions according to photoelectrons obtained by the photoelectric detector. The optical fiber dynamic light scattering detection device has the advantages thatthe particle sizes of the high-concentration particle swarms can be measured by the optical fiber dynamic light scattering detection device in an in-situ manner, the optical fiber dynamic light scattering detection device is small, is low in sample consumption and can be applied to measuring the particle sizes of the high-concentration particle swarms, and light-resistant designs and temperaturecontrol can be facilitated.

Description

technical field

[0001] The invention belongs to the field of photoelectric detection, and more specifically relates to an optical fiber dynamic light scattering detection device for high-concentration particle groups. Background technique

[0002] The particle size and distribution of submicron and nano-particles are the main parameters to characterize their performance, so the measurement of these parameters is of great significance. Dynamic light scattering technology does not require fluorescent labeling of samples, and is the only particle size analysis technology that can realize liquid biopsy, and dynamic light scattering technology is an effective method for measuring the particle size of submicron and nano particles.

[0003] In the dynamic light scattering particle measurement technology, photon correlation spectroscopy is widely used. This method uses a photodetector to receive scattered light at a fixed spatial position for detection. However, due to the extremel...

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