Flexible microfluid equipment for collecting human body sweat and sweat collecting and detecting method thereof

A microfluidic and microfluidic channel technology, which is used in inoculation and ovulation diagnosis, medical science, surgery, etc., can solve the problems of expensive plasma etching machine, separation of silicon wafer and photoresist, and expensive photolithography machine. Conducive to medical testing, reducing limitations, and facilitating popular use

Inactive Publication Date: 2018-03-16
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages: expensive
Its disadvantage: plasma etching machine is expensive
Its disadvantages: (i) as the template is used more often, the photoresist becomes thinner and thinner until it fails, and improper storage of the template will separate the silicon wafer from the photoresist; (ii) the photolithography machine is expensive, and, It needs to consume photoresist, and it needs to use high-precision spin coater to spin coat photoresist
Its disadvantages: high equipment requirements

Method used

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  • Flexible microfluid equipment for collecting human body sweat and sweat collecting and detecting method thereof
  • Flexible microfluid equipment for collecting human body sweat and sweat collecting and detecting method thereof
  • Flexible microfluid equipment for collecting human body sweat and sweat collecting and detecting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] like figure 1 As shown, a flexible microfluidic device for human sweat collection, including a cover 1 and a base 2, the diameter of the base and the cover is 30 mm, the thickness of the cover 1 is 0.2 mm, and the cover 1 corresponds to the sweat color indicator The position of 8 is marked with "+"; the thickness of substrate 2 is 0.5 mm, wherein, substrate 2 has liquid inlet 3, liquid outlet 4 and microfluidic channel 5, and microfluidic channel 5 has capillary 6 and microfluidic channel 5. The liquid chamber 7 and the micro-fluid chamber 7 have a sweat color indicator 8. After the skin adhesive layer (PC2723U, ScapaHealthcare) is pasted on the bottom of the flexible microfluidic substrate 2 for human sweat collection (except for the liquid inlet), the sweat comes out of the sweat glands of the skin , into the liquid inlet 3, the sweat enters the microfluidic channel 5 through the action of the capillary 6, and when passing through the microfluidic chamber 7 in the mi...

Embodiment 2

[0043] like Figure 4 , 5 As shown, a flexible microfluidic device for collecting human sweat, compared with the first embodiment, the shape of the microfluidic channel 5 is changed, and the shape is set to an animal shape, making it more acceptable to children; Figure 4 The circular substrate 2 of the frog pattern is 30 mm in diameter and 0.5 mm in thickness; the liquid inlet 3 is a circular hole with a diameter of 1.5 mm; the capillary 6 has a width of 0.2 mm and a depth of 0.3 mm; the microfluidic cavity 7 is 2 mm in diameter, The depth is 0.4 mm; the microfluidic channel 5 is 0.2 mm wide and 0.3 mm deep; the liquid outlet 4 is 0.2 mm wide and 0.3 mm high; Figure 5 The diameter of the circular base 2 of the butterfly pattern is 30 mm; the liquid inlet 3 is a circular hole with a diameter of 1.5 mm; the width of the capillary 6 is 0.2 mm and the depth is 0.3 mm; the diameter of the micro-liquid cavity 7 is 3 mm and the depth is 0.4 mm ; The microfluidic channel 5 is 0.2 ...

Embodiment 3

[0045] like Image 6 As shown, a microfluidic device for collecting human sweat is designed for athletes or military personnel. Compared with the first embodiment, it is designed to have a large microfluidic cavity 7, and in order to prevent the microfluidic cavity 7 from being too large and causing collapse, the microfluidic cavity 7. A column 9 is arranged in the middle to prevent collapse; among them, the diameter of the base body 2 is 40 mm; the liquid inlet 3 is a circular hole with a diameter of 1.5 mm; the width of the capillary 6 is 0.2 mm and the depth is 0.3 mm; 4 mm, the depth is 0.4 mm; the microfluidic channel 5 is 0.2 mm wide and 0.3 mm deep; the liquid outlet 4 is 0.2 mm wide and 0.3 mm high, and the column 9 is 0.4 mm in diameter.

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Abstract

The invention discloses a set of flexible microfluid equipment for collecting human body sweat and a sweat collecting and detecting method thereof. The flexible microfluid equipment comprises a base body and a cover plate, wherein the base body is used for providing a module of a passage and a cavity for transmitting and accommodating the sweat, and the cover plate is the semitransparent cover plate used for sealing the base body. The base body comprises a sweat inlet, a sweat outlet and a microfluid passage. The microfluid passage comprises a capillary tube and a microfluid cavity, wherein the capillary tube is used for controlling fluids flowing through the passage in the microfluid equipment, and the microfluid cavity is used for storing the sweat and is provided with a displaying agentinside. The equipment is fixed on the human body, after the sweat enters into the microfluid passage, a + mark on the cover plate is positioned by a mobile software, colors in the microfluid cavity at different positions are scanned, so as to obtain the sweat content at some time; meanwhile, after the sweat collecting is finished, the sweat is extracted from the sweat outlet by an injector, and the sweat is used for storing and conducting medical detection. The equipment is easy in usage, low in raw material and processing cost, capable of being massively produced, and wide in applicability.

Description

technical field [0001] The invention relates to a body fluid collection and detection method for special groups of people, such as soldiers marching, patients and children, etc., including liquid output, storing liquid samples and detecting biological indicators in the body fluid. In particular, a flexible microfluidic device for collecting human sweat and a method for collecting and detecting sweat of the device. Background technique [0002] With the increasing focus on health, people's demand for monitoring various indicators of the body has grown by leaps and bounds. The detection of blood, tissue fluid or sweat can be used to track and grasp the health status of the body. The detection of blood and tissue fluid will cause certain damage to the body, so Non-invasive detection using sweat is a trend. Human sweat contains sodium, chloride, lactic acid, urea and small amounts of proteins, peptides and metal ions. The components in sweat can reflect the health status of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/00
CPCA61B10/0064A61B2010/0006
Inventor 王秀锋陈玲欧阳晓平陈尚达文诗华
Owner XIANGTAN UNIV
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