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Vitamin E nanoemulsion, nano cream and preparation method thereof

A nano-emulsion and vitamin technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of poor absorption effect of vitamin E cream, and achieve excellent transdermal penetration ability, environmental friendliness, and distribution range. narrow effect

Active Publication Date: 2018-03-16
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a kind of vitamin E nano-emulsion, nano-emulsion and preparation method thereof. Optimize and simplify the preparation equipment and process, which is convenient for application in industrial production; (2) vitamin E nano-emulsion is made into vitamin E nano-cream to solve the problem of poor absorption effect of traditional vitamin E cream; (3) vitamin E The particle size of the nanoemulsion is controlled in a narrow range, which is conducive to the improvement of the stability and permeability of the nanoemulsion

Method used

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  • Vitamin E nanoemulsion, nano cream and preparation method thereof
  • Vitamin E nanoemulsion, nano cream and preparation method thereof
  • Vitamin E nanoemulsion, nano cream and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Example 1 Preparation of Vitamin E Nanoemulsion of 3wt% Vitamin E

[0042] The raw materials of the vitamin E nanoemulsion: 0.0339g vitamin E (pharmaceutical grade, purity ≥ 98.8%, the same below), 0.1560g isopropyl myristate, 0.1050g Span 20, 0.1750g Tween 80, 0.0840g glycerin , 0.6100 g water.

[0043] Wherein, nanoemulsion base: 14% of oil phase, 32% of surfactant, and the balance is water. The vitamin E mass accounts for 3% of the nanoemulsion matrix mass. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerol) was 1:0.3, the HLB value of the main surfactant was 12.6, and the mass ratio of Tween 80 to Span 20 was 1.67:1.

[0044] Preparation method: first add the oil phase (isopropyl myristate) and vitamin E accurately weighed to the required amount, mix and stir evenly; then add the main surfactant (Span and Tween), the auxiliary surfactant agent (glycerin), and stir evenly; then slowly add distilled water drop by drop, and s...

Embodiment 2

[0045] Example 2 Preparation of Vitamin E Nanoemulsion of 6wt% Vitamin E

[0046]The raw materials of the vitamin E nanoemulsion: 0.0678g vitamin E, 0.1560g isopropyl myristate, 0.1050g Span 20, 0.1750g Tween 80, 0.0840g glycerin, 0.6100g water.

[0047] Wherein, nanoemulsion base: 14% of oil phase, 32% of surfactant, and the balance is water. The vitamin E mass accounts for 6% of the nanoemulsion matrix mass. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerol) was 1:0.3, the HLB value of the main surfactant was 12.6, and the mass ratio of Tween 80 to Span 20 was 1.67:1.

[0048] The preparation method is the same as in Example 1.

Embodiment 3

[0049] Example 3 Preparation of Vitamin E Nanoemulsion of 9wt% Vitamin E

[0050] The raw materials of the vitamin E nanoemulsion: 0.1017g vitamin E, 0.1560g isopropyl myristate, 0.1050g Span 20, 0.1750g Tween 80, 0.0840g glycerin, 0.6100g water.

[0051] Wherein, nanoemulsion base: 14% of oil phase, 32% of surfactant, and the balance is water. The vitamin E mass accounts for 9% of the nanoemulsion matrix mass. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerol) was 1:0.3, the HLB value of the main surfactant was 12.6, and the mass ratio of Tween 80 to Span 20 was 1.67:1.

[0052] The preparation method is the same as in Example 1.

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Abstract

The invention provides a vitamin E nanoemulsion, a nano cream and a preparation method thereof. The vitamin E nanoemulsion is composed of vitamin E, oil phase, main surfactant, cosurfactant and water.The average grain diameter of the vitamin E nanoemulsion is 30-60 nm, and the vitamin E nanoemulsion is an O / W type emulsion and is a uniform system which is transparent or semi-transparent, low in viscosity and good in mobility and has blue opalescence. The method for preparing the vitamin E nanoemulsion includes the steps of mixing an oil phase and vitamin E and performing stirring evenly; sequentially adding the main surfactant and the cosurfactant, and performing stirring evenly; slowly adding distilled water dropwise, performing stirring while adding water, and obtaining the vitamin E nanoemulsion. The vitamin E nano cream is made of the vitamin E nanoemulsion and the O / W type cream substrate, and the manufactured nano cream is white, fine, glossy and good in viscosity. Instruments required for the preparation method and operation steps are simple, and the prepared nano cream is good in stability and high in infiltration capacity and has good application prospect in the directionof cosmetics.

Description

technical field [0001] The invention belongs to the field of daily chemical products and additives thereof, and in particular relates to a vitamin E nano-emulsion, a nano-emulsion and a preparation method thereof. Background technique [0002] In the 21st century, nanotechnology enjoys the reputation of being one of the most promising fields. The National Science and Technology Committee of the United States pointed out in 2000 that in the next 10 years, about 50% of the market sales in the world will use nanotechnology. With the continuous deepening of scientific research, new cosmetics are emerging, and the application of nanotechnology in the field of daily chemicals is gradually increasing. [0003] Vitamin E, also known as tocopherol, is a derivative of chroman. It is a fat-soluble vitamin that is insoluble in water. Its fat-water partition coefficient Log P=10 has a great relationship with the skin. As an antioxidant, vitamin E can protect the skin from oxidative dam...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/37A61K8/34A61K8/06A61Q19/08
CPCA61K8/062A61K8/068A61K8/345A61K8/37A61K8/678A61K2800/522A61Q19/08
Inventor 肖玉秀宗钰王璇璇
Owner WUHAN UNIV
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