Vitamin E nanoemulsion, nano cream and preparation method thereof
A nano-emulsion and vitamin technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of poor absorption effect of vitamin E cream, and achieve excellent transdermal penetration ability, environmental friendliness, and distribution range. narrow effect
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[0041] Example 1 Preparation of Vitamin E Nanoemulsion with 3wt% Vitamin E
[0042] The raw material of the vitamin E nanoemulsion: 0.0339g vitamin E (medical grade, purity ≥98.8%, the same below), 0.1560g isopropyl myristate, 0.1050g Span 20, 0.1750g Tween 80, 0.0840g glycerin , 0.6100g water.
[0043] Among them, the nanoemulsion matrix: 14% oil phase, 32% surfactant, and the balance is water. The quality of vitamin E accounts for 3% of the quality of the nanoemulsion matrix. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerin) is 1:0.3, the HLB value of the main surfactant is 12.6, and the mass ratio of Tween 80 to Span 20 is 1.67:1.
[0044] Preparation method: first add the oil phase (isopropyl myristate) and vitamin E accurately weighed to the required amount, mix and stir evenly; then add the main surfactants (Span and Tween) and surface activity in turn (Glycerin), stir well; then slowly add distilled water dropwise and stir while ad...
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[0045] Example 2 Preparation of Vitamin E Nanoemulsion with 6wt% Vitamin E
[0046] The raw materials of the vitamin E nanoemulsion: 0.0678 g vitamin E, 0.1560 g isopropyl myristate, 0.1050 g Span 20, 0.1750 g Tween 80, 0.0840 g glycerin, and 0.6100 g water.
[0047] Among them, the nanoemulsion matrix: 14% oil phase, 32% surfactant, and the balance is water. The quality of vitamin E accounts for 6% of the quality of the nanoemulsion matrix. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerin) is 1:0.3, the HLB value of the main surfactant is 12.6, and the mass ratio of Tween 80 to Span 20 is 1.67:1.
[0048] The preparation method is the same as in Example 1.
Example Embodiment
[0049] Example 3 Preparation of Vitamin E Nanoemulsion with 9wt% Vitamin E
[0050] The raw materials of the vitamin E nanoemulsion: 0.1017g vitamin E, 0.1560g isopropyl myristate, 0.1050g Span 20, 0.1750g Tween 80, 0.0840g glycerin, 0.6100g water.
[0051] Among them, the nanoemulsion matrix: 14% oil phase, 32% surfactant, and the balance is water. The quality of vitamin E accounts for 9% of the quality of the nanoemulsion matrix. The mass ratio of the main surfactant (Span 20 and Tween 80) to the co-surfactant (glycerin) is 1:0.3, the HLB value of the main surfactant is 12.6, and the mass ratio of Tween 80 to Span 20 is 1.67:1.
[0052] The preparation method is the same as in Example 1.
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