Assembled bone tissue engineering support

Abstract

The invention discloses an assembled bone tissue engineering support which is composed of a closed support shell formed by embedding more than two split shells (1), each split shell (1) is made of pure titanium, and through grooves (2) or through holes are formed in the wall of each split shell (1); a biological material and / or biological material granules having bone repairing effect are put in an inner cavity of the support shell. The bone tissue engineering support has good mechanical performance, can bear pressure of repair sites to avoid to avoid damage to the support caused by surgical external force, has high biocompatibility and can better promote bone growth and improve bone repairing quality.

Description

Technical field [0001] The invention relates to a bone tissue engineering support, in particular to an assembled porous bone tissue engineering support. Background technique [0002] Bone tissue is a complex of cells, organic matrix, and inorganic matrix. The organic matrix provides elasticity to the bone tissue, while the inorganic matrix part provides mechanical strength to the bone tissue. When the bone tissue of the human body is damaged, the bone tissue can be structurally repaired by implanting a bone tissue engineering scaffold. The implanted bone tissue engineering scaffold needs to be biocompatible to facilitate the adhesion, proliferation and differentiation of cells on its surface, and to ensure the deposition of cytoplasmic matrix; at the same time, the bone tissue engineering scaffold needs to be porous and penetrating to It is conducive to the migration of cells, and at the same time provides the necessary channels for the delivery of nutrients and the dischar...

AI Technical Summary

Problems solved by technology

However, its constituent materials are all bioceramics, which have low mechanical strength and can only be used for the repair of bone defects with low strength.

Medical polymer materials have the advantages of certain biocompatibility, degradability, easy processing and wide sources, but their constituent materials are all single medical polymer materials, and there are also problems of low mechanical strength and excessive degradation speed. Its application is also limited

Bone tissue scaffolds made of medical metal materials have high mechanical strength; they are the first choice for hard tissues such as bones and teeth that need to bear high loads, as well as for interventional therapy; however, their constituent materials are all single medical metal materials, which do not have biological activity. After implantation, it is easy to form a fibrous membrane between the tissue and the interface between the scaffold and the tissue for a long time, and the scaffold is easy to loosen and fall off

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