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Amlodipine besylate orally disintegrating tablet prepared through 3D printing and preparation method of orally disintegrating tablet

A kind of technology of amlodipine besylate and amlodipine besylate are applied in the field of amlodipine besylate orally disintegrating tablet and preparation thereof, and can solve the problem of long disintegration time of amlodipine besylate dispersible tablet, Can not meet the urgent needs of patients for medication and other problems, to achieve the effect of improving compliance and fast drug release

Active Publication Date: 2018-03-23
江苏互竑生物医学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commercially available amlodipine besylate dispersible tablets take a long time to disintegrate, which cannot meet the urgent needs of patients

Method used

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  • Amlodipine besylate orally disintegrating tablet prepared through 3D printing and preparation method of orally disintegrating tablet
  • Amlodipine besylate orally disintegrating tablet prepared through 3D printing and preparation method of orally disintegrating tablet
  • Amlodipine besylate orally disintegrating tablet prepared through 3D printing and preparation method of orally disintegrating tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The prescription is as follows:

[0026]

[0027] 3D printing parameters are as follows:

[0028]

[0029] The preparation method is as follows:

[0030] Step 1: According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0031] Step 2: Calculated by mass percentage, mix amlodipine besylate (3%), sucrose (96%), and micropowdered silica gel (1.0%) evenly in proportion, and pack it into the powder box of the 3D printing rapid prototyping machine as a medicine powder ;

[0032] Step 3: Fill the 75% ethanol solution into the cartridge;

[0033] Step 4: The control system outputs commands to control the 3D printing rapid prototyping machine to print amlodibesylate flat disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.20mm on the powder bed, and then prints the nozzle in the direction of ...

Embodiment 2

[0038] The prescription is as follows:

[0039]

[0040] 3D printing parameters are as follows:

[0041]

[0042]

[0043] The preparation method is as follows:

[0044] Step 1: According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0045] Step 2: Calculated by mass percentage, amlodipine besylate (1%), sucrose (63%), pregelatinized starch (29%), povidone K30 (5%), micronized silica gel (1%) 1. Stevioside (1%) is mixed evenly in proportion, and packed into the powder box of the 3D printing rapid prototyping machine as a medicine powder;

[0046] Step 3: Put 1% povidone K30-25% ethanol solution into the cartridge;

[0047] Step 4: The control system outputs instructions to control the 3D printing rapid prototyping machine to print amlodibesylate flat disintegrating tablets: the powder spreading device first spreads a layer of powder with ...

Embodiment 3

[0052] The prescription is as follows:

[0053]

[0054] 3D printing parameters are as follows:

[0055]

[0056] The preparation method is as follows:

[0057] Step 1: According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer;

[0058] Step 2: calculate by mass percent, amlodipine besylate (6%), D-mannitol (84%), sodium carboxymethylcellulose (8%), aspartame (2%) are proportional Mix evenly, and put it into the powder box of the 3D printing rapid prototyping machine as a powder;

[0059] Step 3: Put 50% ethanol solution into the cartridge;

[0060] Step 4: The control system outputs instructions to control the 3D printing rapid prototyping machine to print amlodibesylate flat disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.25mm on the powder bed, and then prints the nozzle in the direction ...

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Abstract

The invention discloses an amlodipine besylate orally disintegrating tablet prepared through 3D printing and a preparation method of the orally disintegrating tablet. The amlodipine besylate orally disintegrating tablet is prepared from components in percentage by mass as follows: 1%-8% of amlodipine besylate, 78%-98% of filler, 1%-10% of a dry adhesive, 0.1%-1.0% of aerosil and 0-2% of a flavoring agent with a 3D printing technology. The amlodipine besylate orally disintegrating tablet prepared with the 3D printing technology has the characteristics of being high in disintegration speed, capable of improving drug taking compliance of patients and the like and is particularly convenient to take by old people, children and people with swallowing difficulty. The dosage suitable for the patients can be customized according to the individual difference of the patients, individualized drug administration and accurate treatment are realized, so that the number of tablets taken by the patients or the step of tablet cutting by a pharmacist can be reduced, the pharmaceutical preparation can play the maximum effect, and the toxic and side effects of the medicine can be minimized.

Description

technical field [0001] The invention belongs to the technical field of drug design, and in particular relates to an orally disintegrating amlodipine besylate tablet prepared by 3D printing and a preparation method thereof. Background technique [0002] Three-dimensional printing technology (three dimension printing, 3DP) is a rapid prototyping technology based on digital models. The core idea of ​​3D printing first originated in the United States at the end of the 19th century, and it was not until the late 1980s that it was developed by the Massachusetts Institute of Technology. 3D printing technology is to design and construct a three-dimensional model on computer software based on the CAD model or CT data of the object. It can quickly and accurately manufacture objects with special shapes or complex internal structures. [0003] 3D printing technology is widely used in biomedicine, automobile manufacturing, aerospace, cultural creativity and other fields. At present, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/04A61K47/26A61K47/32A61K47/38A61K47/36A61K31/4422A61P9/10A61P9/12
CPCA61K9/0056A61K9/2009A61K9/2018A61K9/2027A61K9/2054A61K9/2059A61K9/2095A61K31/4422
Inventor 郑易
Owner 江苏互竑生物医学有限公司
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