Diprophylline tablet and preparation method thereof

A dihydroxyprophylline tablet and a dihydroxyprophylline technology, which are applied in the field of medicine, can solve the problems of affecting the full exertion of medicinal effect, complicated preparation process, low bioavailability and the like, and are convenient to carry and take, simple process, High bioavailability effect

Inactive Publication Date: 2018-03-23
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the characteristics of the conventional preparation technology of the diprophylline tablets currently on the market, the disintegration time of such oral preparations is long, the onset of effect is slow, and the bioavailability is low, thereby affecting the full play of the drug effect, and The preparation process is cumbersome and the cost is high

Method used

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  • Diprophylline tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A dyphylline tablet, made of the following raw materials in weight ratio: 50 parts of dyphylline, 5 parts of loquat dew, 3 parts of Chuanbei, 2 parts of mulberry, 3 parts of Artemisia argyi, 1 part of Coptidis, micro 5 parts of crystalline cellulose, 1 part of hydroxypropyl methylcellulose, 0.5 parts of lubricant, 0.3 parts of stannous chloride, 3 parts of vitamin C, and 1 part of vitamin E.

[0023] Wherein, the lubricant is a mixture of polyethylene glycol, simethicone, and pharmaceutical grade cross-linked polyvinylpyrrolidone in a weight ratio of 1:2:3.

[0024] A kind of preparation method of dyphylline tablet, comprises the steps:

[0025] (1) Wash Chuanbei, mulberry, Artemisia argyi and Coptis chinensis, dry in vacuum at low temperature, pulverize under the action of supersonic airflow, pulverize to nanometer level, and make filler;

[0026] (2) Mix the active ingredient diprophylline and the filler evenly, add purified water to make a soft material;

[0027] (...

Embodiment 2

[0031] A dyphylline tablet, made of the following raw materials in weight ratio: 65 parts of dyphylline, 8 parts of loquat dew, 6 parts of Chuanbei, 5 parts of mulberry, 4 parts of Artemisia argyi leaves, 3 parts of Coptis chinensis, micro 8 parts of crystalline cellulose, 8 parts of hydroxypropyl methylcellulose, 1.2 parts of lubricant, 0.5 parts of stannous chloride, 5 parts of vitamin C, and 3 parts of vitamin E.

[0032] Wherein, the lubricant is a mixture of polyethylene glycol, simethicone, and pharmaceutical grade cross-linked polyvinylpyrrolidone in a weight ratio of 1:2:3.

[0033] A kind of preparation method of dyphylline tablet, comprises the steps:

[0034] (1) Wash Chuanbei, mulberry, Artemisia argyi and Coptis chinensis, dry in vacuum at low temperature, pulverize under the action of supersonic airflow, pulverize to nanometer level, and make filler;

[0035] (2) Mix the active ingredient diprophylline and the filler evenly, add purified water to make a soft mat...

Embodiment 3

[0040] A dyphylline tablet, made of the following raw materials in weight ratio: 55 parts of dyphylline, 6 parts of loquat dew, 3 parts of Chuanbei, 5 parts of mulberry, 3 parts of mugwort leaves, 3 parts of Coptis chinensis, micro 8 parts of crystalline cellulose, 4 parts of hydroxypropyl methylcellulose, 1.2 parts of lubricant, 0.5 parts of stannous chloride, 5 parts of vitamin C, and 3 parts of vitamin E.

[0041] Wherein, the lubricant is a mixture of polyethylene glycol, simethicone, and pharmaceutical grade cross-linked polyvinylpyrrolidone in a weight ratio of 1:2:3.

[0042] A kind of preparation method of dyphylline tablet, comprises the steps:

[0043] (1) Wash Chuanbei, mulberry, Artemisia argyi and Coptis chinensis, dry in vacuum at low temperature, pulverize under the action of supersonic airflow, pulverize to nanometer level, and make filler;

[0044] (2) Mix the active ingredient diprophylline and the filler evenly, add purified water to make a soft material; ...

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Abstract

The invention provides a dyphylline tablet and a preparation method thereof, which relate to the technical field of medicine, including dyphylline, loquat dew, Chuanbei, mulberry, mugwort leaves, berberine, microcrystalline cellulose, hydroxypropyl methyl Cellulose, lubricant, antioxidant, vitamin C, vitamin E; the preparation method is as follows: wash Chuanbei, mulberry, mugwort leaf, and coptis, dry in low-temperature vacuum, and pulverize with supersonic airflow; add dihydroxyprophylline and mix evenly, Add water; add microcrystalline cellulose, hydroxypropyl methylcellulose, antioxidants, vitamin C, and vitamin E and mix well; pour the material into a granulator to make tablet cores; take lubricant, dry it, and crush it to the nanometer level , sprayed on the tablet core to obtain diprophylline tablets. The dihydroxyprophylline tablet of the present invention has high bioavailability, stable disintegration and dissolution speed, high dissolution rate, stable quality, stable drug release speed, convenient carrying and taking, simple process, few types of auxiliary materials, short production process and low cost. Low.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a diprophylline tablet and a preparation method thereof. Background technique [0002] Asthma is a common respiratory disease, and it is also a frequently-occurring disease. There are more than 100 million asthmatics in the world, and the prevalence of asthma in my country is close to 1%, and the number of patients is more than 10 million, half of which are onset before the age of 12. Asthma is a disease that seriously endangers people's physical and mental health, weakens working ability and reduces the quality of life, and is difficult to be cured. It is manifested as sudden chest tightness, irritating cough, and dyspnea mainly accompanied by wheezing. The attack time can be long or short, and it can last for several weeks in severe cases, or it can be a chronic process of recurrent attacks. According to a survey report, the situation of asthmatic patients is not ideal. As ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61K47/02A61K31/522A61P11/06A61P37/04A61K31/355A61K31/375
CPCA61K31/522A61K9/2009A61K9/2054A61K31/355A61K31/375A61K36/282A61K36/605A61K36/718A61K36/73A61K36/8966A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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