Evidence library-based Chinese herbal medicine hepatotoxicity assessment and identification method

Abstract

The invention discloses an evidence library-based Chinese herbal medicine hepatotoxicity assessment and identification method. Based on existing drug metabolic enzyme mediated active metabolite (RMs)research results, a thinking mode of how to establish an active metabolite (RMs) evidence library, Chinese herbal medicine identification evidence library and Chinese herbal medicine hepatotoxicity individual report evidence library-based multi-dimensional multi-layer network topology evidence library based on evidence based medicine is discussed; basic biomarker information, individual clinical patient report information, Chinese herbal medicine feature information and the like are integrated with a Chinese herbal medicine hepatotoxicity identification-related evidence system; related core indexes are extracted to form an evidence set library mode; a scientific hypothesis of the evidence library-based Chinese herbal medicine hepatotoxicity assessment and identification method based on theevidence-based medicine is established; various united evidences related to Chinese herbal medicine hepatotoxicity are generated and assessed from the perspective of evidence collection; basic evidences are introduced in clinical work; and a new thought and method is provided for scientifically assessing the Chinese herbal medicine hepatotoxicity.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a method for evaluating and identifying liver toxicity of Chinese herbal medicines based on an evidence base. Background technique [0002] The liver is one of the important metabolic organs of the human body and an important part of the human life cycle. The decomposition and metabolism of any drug can only be carried out smoothly with the assistance of liver function. Therefore, diseases caused by the liver as an important organ of metabolism have been paid close attention to by world medicine. Drug-induced liver injury (DILI) refers to an important disease caused by toxic damage caused by the drug itself or its metabolites, or an allergic reaction to drugs and metabolites during the course of drug use. Drug hepatotoxic injury refers to liver damage induced by various prescription and non-prescription drugs (such as chemical drugs, biological agents, traditional Chinese ...

AI Technical Summary

Problems solved by technology

Due to the lack of HILI identification norms and standards that reflect the complexity of Chinese herbal medicines, the diagnostic criteria for HILI are quite different. In addition, there are very few medical records in clinical diagnosis that record the composition and dosage of Chinese herbal medicines that cause hepatotoxicity. This leads to HILI diagnostic bias.

Due to the particularity of Chinese herbal medicine compound prescriptions, the current international DILI identification method is not suitable for HILI identification. Therefore, the identification method and standard specifically for the characteristics of HILI are still an unknown field, which greatly limits the scientific evaluation and evaluation of Chinese herbal medicine liver toxicity research. identify

[0004] Problems faced in clinical liver toxicity evaluation and identification of Chinese herbal medicine: The diagnosis of drug-induced liver injury is a scientific problem that plagues clinicians in the medical field today. Due to the lack of specific indicators, there is currently no specific identification technology and method to diagnose suspected drug-induced liver injury Toxicity damage, currently clinicians can only rely on the "exclusion method" to judge the clinical symptoms of patients

However, since the liver toxicity of traditional Chinese medicine will not be marked in the instructions (additional content of the scale), the specificity and accuracy of this scoring method are not high, and because the diagnostic criteria have not improved much over the years, many important interferences Sexual factors such as hepatitis E virus infection were not included in the diagnostic criteria, which seriously affected the accuracy of the method

A 2010 study in the journal Hepatology showed that the consistency rate of different clinicians using RUCAM to identify was only 19%.

However, the current identification methods of Chinese herbal medicine liver toxicity have considerable limitations: (1) The clinical manifestations of Chinese herbal medicine liver toxicity are diverse and complex, and are covered by underlying diseases. Clinical symptoms and biochemical tests often lack specific indicators. Requirements for quality of life, liver biopsy is often difficult to implement because of its large trauma

(2) The combination of Chinese and Western medicines widely exists clinically, which makes the confirmation and in-depth study of Chinese medicine liver toxicity extremely complicated, thus giving patients the false impression that Chinese herbal medicines cause liver toxicity and causing serious losses to patients

(3) The composition of Chinese herbal medicines is complex. At present, there is a lack of more reliable research data on the mechanism of liver toxicity, credible clinical research data on liver toxicity of Chinese medicines, and information on related Chinese herbal medicines, which brings huge hidden dangers to precise clinical diagnosis and treatment.

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