Natural oyster calcium carbonate preparation for prevention and treatment of calcium deficiency disease and preparing method thereof

A technology of oyster calcium and calcium deficiency, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, antidote, etc., can solve the problem that the bioavailability cannot be greatly improved, and the absorption and digestion are not good and other problems, to achieve the effect of not affecting bioavailability, promoting calcium ion absorption, and increasing digestive juice secretion

Active Publication Date: 2018-04-20
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this dosage form has the following problems: due to reasons such as preparation technology, most oral preparations of drugs have the problems of long dissolution time, low dissolution rate, and poor absorption after taking, thus failing to maximize the efficacy of the drug. , also directly affects the therapeutic effect, so its bioavailability cannot be greatly improved
However, different individuals may be deficient in one or more elements, and the same supplementary calcium preparation limits the use of individuals who lack a single calcium element; and for individuals who lack multiple metal elements, different metal elements Supplementation may produce antagonism and affect the absorption of both or one of them. For example, calcium and iron are supplemented together. Calcium carbonate and iron compounds interact in the stomach to produce insoluble iron carbonate precipitation, which affects the absorption of iron. Digestion is also bad

Method used

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  • Natural oyster calcium carbonate preparation for prevention and treatment of calcium deficiency disease and preparing method thereof
  • Natural oyster calcium carbonate preparation for prevention and treatment of calcium deficiency disease and preparing method thereof
  • Natural oyster calcium carbonate preparation for prevention and treatment of calcium deficiency disease and preparing method thereof

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preparation example Construction

[0077] On the other hand, the present invention provides a kind of preparation method of the natural oyster calcium preparation that is used for preventing and treating calcium deficiency, and this preparation method comprises the following steps:

[0078] Step (1), processing natural oyster shells to obtain oyster calcium;

[0079] Sub-step (1-1), detecting and cleaning natural oyster shells;

[0080] Sub-step (1-2), oyster shell carbonization dehydration, high temperature activation;

[0081] Sub-step (1-3), adding water to the activated oyster shell to expand, and then passing carbon dioxide gas to carbonize to obtain oyster calcium.

[0082] In step (2), the oyster calcium is uniformly mixed with auxiliary materials, and compressed into tablets or granulated under low pressure to obtain the oyster calcium preparation.

[0083] The main structure of natural oyster shells is mostly in the form of flakes or strips, with large internal pores and good connectivity of the pore...

Embodiment 1

[0096] The preparation of embodiment 1 natural type oyster calcium chewable tablet

[0097] The raw materials used are as follows:

[0098]

[0099] The natural type oyster calcium chewable tablet is prepared by the following production process:

[0100] (1) Detect natural oyster shells, select lead content less than 5mg / kg, cadmium content less than 0.3mg / kg, arsenic content less than 2mg / kg, mercury content less than 0.2mg / kg, copper content less than Oyster shells with a calcium content of 20mg / kg and more than 38%; coarsely crush the oyster shells to make them into small pieces, and ultrasonically clean them at 40kHz for 4h;

[0101] (2) Oyster shells are carbonized and dehydrated at 300-400°C, and activated at a high temperature of 1200°C until the calcium content is 68%-70%;

[0102] (3) add deionized water to the activated oyster shell at a ratio of 1:1, puff it at 100°C and 1.5MPa, and after drying, carbon dioxide gas is introduced into it for carbonization reacti...

Embodiment 2

[0105] The preparation of embodiment 2 natural type oyster calcium chewable tablets

[0106] The raw materials used are as follows:

[0107]

[0108] The production process for preparing natural oyster calcium chewable tablets is the same as in Example 1. After testing, the average loading is 1.0g / tablet, containing 0.66g / tablet of oyster calcium, 0.13g / tablet of gum arabic, and 1.33 mg / tablet of porphyrin iron (0.114 mg / tablet of iron).

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Abstract

The invention discloses a natural oyster calcium preparation for prevention and treatment of calcium deficiency disease and a preparing method thereof for the first time. A natural oyster calcium compound with calcium carbonate as a main component is separated or extracted from oyster shells, and has the effect of preventing and treating calcium deficiency disease. The preparing method of the calcium preparation mainly comprises the steps of carrying out carbonization, activation, expansion, carbonization and drying of the oyster shells, and smashing and sieving an extract to extract the calcium compound with calcium carbonate as the main component, and the calcium compound belongs to the natural extract and can be used for supplementation of calcium for children, pregnant women and the elderly; compared with a technology for preparing calcium carbonate from raw material limestone, the technology process is equivalent, but the produced calcium carbonate compound has higher purity, is used for preparing granules and chewable tablets and has higher bioavailability.

Description

technical field [0001] The invention relates to a calcium preparation and a preparation method thereof, in particular to a natural oyster calcium carbonate preparation capable of preventing and treating calcium deficiency and a preparation method thereof. Background technique [0002] Calcium is an essential mineral element for the human body and an important component of the body's bones and teeth. 99% of the calcium in the human body is concentrated in teeth and bones, and a small amount of trace elements such as phosphorus and magnesium play an important role in increasing the hardness of bones. Calcium can increase the peak bone mass of young people to prepare for bone loss after old age; and calcium can promote bone cell synthesis, delay bone loss after menopause and old age in women, and prevent postmenopausal osteoporosis. At the same time, calcium participates in various physiological functions of the human body. A large number of studies have shown that calcium is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K47/36A61K47/12A61K47/54A61P3/02A61P7/06A61P39/00A61K31/555
CPCA61K31/555A61K33/06A61K47/12A61K47/36A61K2300/00
Inventor 傅苗青周白水巩绪彦李桂芳
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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