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A method for extracting phenylethanol glycosides from Cistanche tubulosa and its application

A technology of Cistanche deserticola and phenylethanol glycosides, which is applied in the direction of chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of large solvent consumption, low extraction rate, and long time consumption, and achieve low solvent consumption, High extraction efficiency and short extraction time

Active Publication Date: 2021-07-20
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the solvent extraction method has the disadvantages of large amount of solvent and long time consumption.
Microwave extraction has the advantages of simple equipment, short operation time, and less solvent consumption, but its extraction rate is low, it is not easy to automate, and it lacks the possibility of online connection with other instruments
Ultrasonic extraction is easy to operate, simple in equipment, and high in extraction rate, but it has long working hours, consumes a large amount of solvent, and is not easy to automate

Method used

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  • A method for extracting phenylethanol glycosides from Cistanche tubulosa and its application
  • A method for extracting phenylethanol glycosides from Cistanche tubulosa and its application
  • A method for extracting phenylethanol glycosides from Cistanche tubulosa and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Cistanche tuberosum (purchased from Xinjiang Hetian Cistanche Tang Biotechnology Co., Ltd.) was crushed, passed through a 50-mesh sieve, dried in an oven at 70°C for 12 hours, weighed 14g, and added 126ml of 50% ethanol aqueous solution (solid-liquid ratio 1 :9 (mass g / volume ml)), at 70°C, adjust the speed of the Fluko high-shear homogeneous emulsifier to 16000rpm for extraction, extract once, centrifugally filter, get 1mL filtrate and use Waters high-performance liquid chromatography to detect, the remaining The filtrate was dried under reduced pressure to obtain the phenylethanol glycoside extract which was vacuum freeze-dried into powder. Calculate the total yield of echinacoside and verbascoside in the extract ≥ 2.23%.

Embodiment 2

[0030] Cistanche tuberosum (purchased from Xinjiang Hetian Cistanche Tang Biotechnology Co., Ltd.) was crushed, passed through a 50-mesh sieve, dried in an oven at 70°C for 12 hours, weighed 14g, and added 126ml of 50% ethanol aqueous solution (solid-liquid ratio 1 : 9 (mass g / volume ml)), at 70°C, adjust the speed of the Fluko high-shear homogeneous emulsifier to 19000rpm for extraction, extract once, centrifugally filter, get 1mL filtrate and use Waters high-performance liquid chromatography to detect, the remaining The filtrate was dried under reduced pressure to obtain the phenylethanol glycoside extract which was vacuum freeze-dried into powder. Calculate the total yield of echinacoside and verbascoside in the extract ≥ 2.28%.

Embodiment 3

[0032] Cistanche tuberosum (purchased from Xinjiang Hetian Cistanche Tang Biotechnology Co., Ltd.) was crushed, passed through a 50-mesh sieve, dried in an oven at 70°C for 12 hours, weighed 14g, and added 126ml of 50% ethanol aqueous solution (solid-liquid ratio 1 :9 (mass g / volume ml)), at 70°C, adjust the speed of the Fluko high-shear homogeneous emulsifier to 22000rpm for extraction, extract once, centrifugally filter, get 1mL filtrate and use Waters high-performance liquid chromatography to detect, the remaining The filtrate was dried under reduced pressure and freeze-dried in vacuo to obtain a powdered phenylethanol glycoside extract. Calculate the total yield of echinacoside and verbascoside in the extract ≥ 2.35%.

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Abstract

The invention discloses a method for extracting phenylethanol glycosides from Cistanche tubulosa and its application. The method for extracting phenylethanol glycosides from Cistanche tubulosa of the present invention comprises: step 1, crushing: pulverizing the dried fleshy stem of Cistanche tubulosa, sieving, and drying; step 2, extracting: in the tube of step 1 Add 50% ethanol aqueous solution to Cistanche cistanche powder, heat to 70°C, use a high-shear homogeneous emulsifier to extract at 70°C for 2 minutes, and extract once; step 3, centrifugally filter the extract obtained in step 2, and depressurize Drying, vacuum freeze-drying into powder to obtain phenylethanol glycosides. The method has short extraction time, less solvent consumption, high extraction efficiency, simple high-shear equipment, easy to be used in series with other equipment, and easy to realize automatic production.

Description

technical field [0001] The invention relates to the technical field of compound extraction, in particular to a method for extracting phenylethanol glycosides from Cistanche tubulosa and its application. Background technique [0002] Cistanche tubulosa is a parasitic plant of the family Danaceae, which is produced in Xinjiang, my country, and is listed as top grade in "Shen Ben Cao Jing". The phenylethanol glycosides are the main active ingredients of Cistanche tubulosa. Studies have shown that phenylethanol glycosides have the functions of protecting the liver, anti-oxidation, anti-aging, regulating nerve cells, enhancing immunity, and improving memory. Echinacoside and verbascoside are the most effective components in the phenylethanol glycosides of Cistanche tubulosa, accounting for more than 90% of the total phenylethanol glycosides. Existing methods for extracting phenylethanol glycosides from Cistanche tubulosa include solvent extraction, microwave-assisted extraction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08
CPCC07H1/08C07H15/18
Inventor 李雪琴裴文静郭瑞丽张金利
Owner SHIHEZI UNIVERSITY
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