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Gel material for 3D printing of artificial cartilage as well as preparation method and application

A 3D printing and gel material technology, applied in metal processing equipment, 3D object support structure, additive manufacturing, etc., can solve the problem of unsatisfactory cartilage precision and surface quality, difficult hot-melt bonding of functional materials, and damage to the chemical composition of raw materials and other issues, to achieve excellent biocompatibility, high self-adhesive strength, and low cost

Inactive Publication Date: 2018-05-15
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that the finished cartilage in the existing 3D printing technology is not ideal in terms of accuracy and surface quality. High temperature conditions will destroy the chemical composition of raw materials. Since the temperature has a great impact on the effect of fusion lamination molding, the finished product effect is not stable enough and takes a long time. Long and high cost, at the same time, in the conventional fused deposition molding process, some functional materials are difficult to achieve hot-melt bonding molding, and the use of adhesives will adversely affect the cartilage material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation process of 3D printing cartilage gel material is as follows:

[0031] Mix 78kg of hydroxyapatite powder, 3kg of aluminum hydroxide, 4kg of potassium methyl silicate and 15kg of calcium alginate powder, place in a vacuum drying oven, dry at 85°C for 10h, take it out, and then use fine Grind with a grinder to obtain a mixed powder with a particle size of 100-300nm; then take 38kg of the mixed powder, prepare it by adding 15kg of glycerin, and add 1kg of calcium stearate to make a paste suitable for 3D printing Gel-like cartilage material, during the preparation process, glycerin was divided into 4 additions, each preparation time was 80min, and the stirring speed during preparation was 400r / min;

[0032] The application process of 3D printing cartilage gel material is as follows:

[0033] Add the gel material to the feed port of the 3D printer. The nozzle diameter of the 3D printer is 0.3mm, the printing accuracy of the XY axis is 0.01mm, the printing acc...

Embodiment 2

[0035] The preparation process of 3D printing cartilage gel material is as follows:

[0036] Mix 81kg of hydroxyapatite powder, 2kg of aluminum hydroxide, 3kg of potassium methyl silicate and 14kg of potassium alginate powder, put them in a vacuum drying oven, dry them at 80°C for 12h, take them out, and then use fine Grind with a grinder to obtain a mixed powder with a particle size of 100-300nm; then take 30kg of the mixed powder, prepare it by adding 18kg of glycerin, and add 2kg of calcium stearate to make a paste suitable for 3D printing Gel-like cartilage material, during the preparation process, glycerin was divided into three additions, each preparation time was 60min, and the stirring speed during preparation was 500r / min;

[0037] The application process of 3D printing cartilage gel material is as follows:

[0038] Add the gel material to the feed port of the 3D printer. The nozzle diameter of the 3D printer is 0.2mm, the printing accuracy of the XY axis is 0.01mm, ...

Embodiment 3

[0040] The preparation process of 3D printing cartilage gel material is as follows:

[0041] Mix 74kg of hydroxyapatite powder, 4kg of aluminum hydroxide, 5kg of potassium methyl silicate and 17kg of sodium alginate powder, place in a vacuum oven, dry at 90°C for 8 hours, take it out, and then use fine Grind with a grinder to obtain a mixed powder with a particle size of 100-300nm; then take 45kg of the mixed powder, prepare it by adding 15kg of glycerin, and add 2kg of calcium stearate to make a paste suitable for 3D printing Shaped gel cartilage material, during the preparation process, glycerin was divided into 5 additions, each preparation time was 90min, and the stirring speed during preparation was 300r / min;

[0042] The application process of 3D printing cartilage gel material is as follows:

[0043] Add the gel material to the feed port of the 3D printer. The diameter of the nozzle of the 3D printer is 0.4mm, the printing accuracy of the XY axis is 0.02mm, the printin...

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Abstract

The invention belongs to the technical field of 3D printing materials, and provides a gel material for 3D printing of an artificial cartilage as well as a preparation method and application. The method comprises the following steps: firstly, uniformly mixing hydroxyapatite, aluminum hydroxide, potassium trimethylsilanolate and an alginate powder, then performing vacuum drying and fine grinding, and adding glycerinum and calcium stearate for separated modulations, so as to obtain a pasty gel cartilage material; then performing 3D printing molding on the gel material, and further maintaining thegel material in water, so as to obtain a cartilage tissue. Compared with a conventional method, the method has the advantages that the prepared 3D-printed cartilage gel material is high in bonding strength, high in plasticity and excellent in material quality; a prepared cartilage finished product is high in biocompatibility and surface activity, high in strength, relatively high in precision andhigh in surface quality and has a stable effect; furthermore, the whole preparation process is simple, low in cost, relatively short in time and suitable for being popularized and used.

Description

technical field [0001] The invention belongs to the technical field of 3D printing materials, and provides a gel material for 3D printing artificial cartilage, a preparation method and an application method. Background technique [0002] 3D printing technology, a type of rapid prototyping technology, is a technology based on digital model files, using bondable materials such as powdered metal or plastic, to construct objects by layer-by-layer printing. In the past, it was often used to make models in the fields of mold manufacturing and industrial design, and is now gradually being used for direct manufacturing of some products, especially some high-value applications that have already used this technology to print parts. In recent years, especially in the medical field, including craniofacial surgery, dentistry, orthopedics and other operations, it has been gradually applied and developed. [0003] The current clinical applications of 3D printing technology in orthopedics ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/52A61L27/20B29C64/112B29C64/379B33Y10/00B33Y40/00B33Y70/00
CPCA61L27/12A61L27/20A61L27/52A61L2400/06A61L2430/06B33Y10/00B33Y40/00B33Y70/00C08L5/04
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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