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A method for detecting a compound danshen tablet by adopting an HPLC-UV-ELSD process

A technology of HPLC-UV-ELSD and Compound Danshen Tablets, which is applied in the field of traditional Chinese medicine detection, can solve the problems of repeated and cumbersome inspection process, cannot fully reflect the changes of ingredients, and fail to evaluate, so as to save analysis time and simplify the inspection process Effect

Active Publication Date: 2018-05-15
广西壮族自治区食品药品检验所
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Problems solved by technology

This quality standard not only repeats the inspection process, but also cannot fully reflect the changes in the composition of this product during the preparation process.
Studies have reported known lipid-soluble components of salvia diterpene quinones such as dihydrotanshinone Ⅰ, cryptotanshinone and tanshinone Ⅰ, and water-soluble components of phenolic acids such as danshensu, protocatechualdehyde, rosmarinic acid, salvianolic acid B, etc. , notoginseng saponins such as ginsenoside Rd were not evaluated

Method used

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  • A method for detecting a compound danshen tablet by adopting an HPLC-UV-ELSD process
  • A method for detecting a compound danshen tablet by adopting an HPLC-UV-ELSD process
  • A method for detecting a compound danshen tablet by adopting an HPLC-UV-ELSD process

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Embodiment

[0042] Embodiment, content is as follows:

[0043] 1. Instruments, reagents and samples:

[0044] (1) Instruments: Waters 2695 high performance liquid chromatography, 2487 ultraviolet detector—ALLtech 2000ES evaporative light scattering detector detection; MILLI-PROA pure water processor;

[0045] (2) Reagents: Danshensu sodium reference substance (provided by China Institute for Food and Drug Control, batch number 110855-200508, for content determination), protocatechualdehyde reference substance (provided by China Institute for Food and Drug Control, batch number 110810-200506, For content determination), rosmarinic acid reference substance (provided by China Institute for Food and Drug Control, batch number 111871-201203, for content determination, content is 98.8%), salvianolic acid B reference substance (China Food and Drug Control Research Institute Institute for Food and Drug Control, batch number 111562-201212, for content determination, the content is 95.4%), dihydro...

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Abstract

A method for detecting a compound danshen tablet by adopting an HPLC-UV-ELSD process is disclosed. Characteristic spectrums of danshen root and radix notoginseng in the compound danshen tablet are studied by adopting gradient elution and detection wavelength changing in liquid chromatography and an ultraviolet detector-tandem evaporative light-scattering detector. The method can perform total-information control on the compound danshen tablet, simplifies a detection process, saves analysis time, and can be used for quality control and comprehensive evaluation of the compound danshen tablet.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine detection, in particular to a method for detecting compound salvia miltiorrhiza tablets by using an HPLC-UV-ELSD method. Background technique [0002] Compound Danshen tablet is composed of Danshen, Panax notoginseng and Borneol. It has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is a commonly used traditional Chinese medicine prescription for clinical treatment of coronary heart disease, chest tightness and angina pectoris. Studies have shown that the active ingredients of Salvia miltiorrhiza are mainly fat-soluble diterpene quinones and water-soluble salvianolic acids, which have anti-oxidation, anti-atherosclerosis, reducing myocardial oxygen consumption and other cardiovascular effects and anti-tumor effects; Panax notoginseng Saponins have pharmacological effects such as dilating blood vessels, reducing myocar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 罗轶张涛朱雪妍林敬开黄博谢培德
Owner 广西壮族自治区食品药品检验所
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