A liposome dispersion loaded with AIE molecules and its preparation method and application

Abstract

The invention relates to AIE molecules-loaded liposome dispersion liquid, and a preparation method and application thereof. The liposome dispersion liquid comprises a phospholipid compound microspherein which AIE molecules are dissolved, and a solvent for dispersing the phospholipid compound microsphere, and the AIE molecules are lipid-soluble molecules having the AIE effect. The preparation method of the liposome dispersion liquid is very simple, the prepared liposome dispersion liquid has good biocompatibility and uniform dispersibility, the particle size is between 100 and 300nm, specificrecognition of tumor cells can be achieved by utilizing the EPR effect of a tumor tissue, reactive oxygen can be produced after degradation in cells and illumination by light under specific wavelengths to kill the tumor cells, and the liposome dispersion liquid can be used for tumor treatment by adopting a PDT therapy method; compared with a traditional PDT therapy method, only partial illumination is needed, and there is no need to perform in a dark room, so that a patient can move freely to some extent.

Description

Technical field [0001] The present invention relates to the field of biochemical structure, in particular to a liposome dispersion loaded with AIE molecules, and a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT) is a new therapy that has received much attention in recent years for the treatment of tumors. Its principle is to use certain photosensitive drugs to generate active molecules such as singlet oxygen and free radicals under the irradiation of lasers, etc., thereby interfering with the growth of tumor cells and Cause his death. This therapy needs to be performed in a dark room, and after the photosensitizer is injected into the body, local irradiation of the lesion tissue is required to avoid phototoxicity to other normal tissues. In some cases, surgery is even required, which limits the patient’s health to a certain extent. Freedom of movement, and because currently clinically approved photosensitive drugs can only eff...

AI Technical Summary

Problems solved by technology

However, such reports are rarely seen in the prior art, and there is little literature support for whether AIE molecules can be successfully dispersed in liposomes or their analogs to achieve tumor PDT treatment. Those skilled in the art need further research to propose A new idea, choose suitable AIE molecules and liposomes, and propose a better preparation method to realize this idea

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