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Compound nanoemulsion for treating skin tinea and preparation method of compound nanoemulsion

A nanoemulsion and compound technology, applied in the field of medicine, can solve the problems of inability to quickly relieve the pain of patients, low drug penetration rate, short drug effect time, etc., and achieve the effects of improving bioavailability, obvious curative effect and low cost.

Inactive Publication Date: 2018-06-01
杨凌华翼纳米医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs only have partial effects, and the transdermal rate of the drugs is not high, the loss of the drugs is relatively large, and the drug effect time is short, so the pain of the patients cannot be relieved quickly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Castor oil polyoxyethylene ether EL-402 1.79g, 2-phenylethyl alcohol 2.72g, dimethyl sulfoxide 0.08g, peppermint oil 0.68g, tea tree oil 0.68g, eucalyptus oil 1.36g, tolnaftate 0.27g, ichthyol 10.86g, distilled water 61.54g

[0073] 1) Weigh the oil phase, surfactant, co-surfactant, co-solvent, tolnaftate, ichthyol and distilled water according to the proportion of the formula;

[0074] 2) Dissolve ichthyol in distilled water;

[0075] 3) Mix the oil phase, co-surfactant, and co-solvent to completely dissolve tolnaftate;

[0076] 4) Add surfactant to step 3. mix;

[0077] 5) At 20°C to 25°C, slowly drop the ichthyolite aqueous solution into step 4, and stir thoroughly until a clear, transparent, low-viscosity and fluid black nanoemulsion liquid is formed.

Embodiment 2

[0079] Castor oil polyoxyethylene ether EL-4020.20g, 2-phenylethyl alcohol 4.03g, dimethyl sulfoxide 0.08g, peppermint oil 0.67g, tea tree oil 0.67g, eucalyptus oil 1.34g, tolnaftate 0.27g, ichthyol 10.91g, distilled water 61.81g

[0080] Concrete steps are as embodiment 1.

Embodiment 3

[0082] Castor oil polyoxyethylene ether EL-40 17.19g, 2-phenylethyl alcohol 4.91g, dimethyl sulfoxide 0.07g, peppermint oil 0.61g, tea tree oil 0.61g, eucalyptus oil 1.22g, tolnaftate 0.24g, Ichthyosis 11.27g, distilled water 63.86g

[0083] Concrete steps are as embodiment 1.

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PUM

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Abstract

The invention discloses a compound nanoemulsion for treating skin tinea and a preparation method of the compound nanoemulsion. The compound nanoemulsion is prepared from main components as follows: 15.67%-21.79% of a surfactant, 2.72%-8.96% of a cosurfactant, 0.07%-0.09% of a cosolvent, 0.59%-1.66% of peppermint oil, 0.59%-1.66% of tea tree oil, 1.19%-3.32% of eucalyptus oil, 0.24%-0.89% of tolnaftate, 9.96%-11.39% of ichthammol and the balance of distilled water, wherein the total mass percentage of the components is 100%; tophanate is an antifungal agent; the tea tree oil and the eucalyptusoil both have antifungal effects. The ichthammol has disinfecting and preservative effects. The compound nanoemulsion has particle size of 1-100 nm, is clear and transparent black liquid, has the advantages of good skin permeability, good slow release property and the like, and has obvious curative effect on skin tinea.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound nanoemulsion for treating skin ringworm and a preparation method thereof. Background technique [0002] Tolnaftate is an antifungal drug, which is used to treat and prevent various types of superficial fungal infections, such as tinea capitis, tinea manus, tinea pedis, jock itch, tinea corporis, etc., especially tinea manus and pedis. Tolnaftate is cheap, non-irritating, and effective. In this field, therapeutic drugs are growing at a rate of 15% per year. At present, the domestic antifungal topical drug market has a capacity of 2.5 billion yuan, and the market potential is huge. Ichthyote is a phenolic antiseptic, which has mild antiseptic and stimulating effects, and has antibacterial, anti-inflammatory, antipruritic, secretion-inhibiting and detumescent effects. Peppermint oil can be applied to the skin or mucous membranes to produce a cooling sensation to relieve discomfor...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/107A61K47/20A61K47/44A61K47/10A61P17/00A61P31/10A61K35/04A61K31/27
CPCA61K35/04A61K9/0014A61K9/1075A61K31/27A61K36/534A61K36/61A61K47/10A61K47/20A61K47/44A61K2300/00
Inventor 欧阳五庆吴小利欧阳伸雨
Owner 杨凌华翼纳米医药科技有限公司