A fluorescent sensor and its application in the determination of niclosamide

A fluorescent sensor and ink technology, applied in the field of fluorescent sensors, can solve the problems of large error of niclosamide, pollute the environment, low sensitivity, etc., and achieve the effects of high accuracy, less sample consumption, and improved sensitivity

Inactive Publication Date: 2019-09-24
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above defects or improvement needs of the prior art, the present invention provides a fluorescent sensor and its application in the determination of niclosamide, wherein by fully combining the characteristics and requirements of the determination means of niclosamide, targeted detection of chlorine Niclosamide assay means and methods were redesigned, and a fluorescent sensor with high detection sensitivity, high accuracy, fast and easy was developed correspondingly for the determination of niclosamide, thereby solving the problem of niclosamide determination in the prior art. Technical problems such as large error, low sensitivity, high cost, and environmental pollution

Method used

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  • A fluorescent sensor and its application in the determination of niclosamide
  • A fluorescent sensor and its application in the determination of niclosamide
  • A fluorescent sensor and its application in the determination of niclosamide

Examples

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Embodiment 1

[0052] In the present embodiment, the base material of the fluorescent sensor is filter paper No. whatman#1, and the nano-zinc powder ink is composed of the following components in mass percentage: 5.2% of nano-zinc powder, 29.4% of ethylene glycol, 6% of isopropanol, and 14% of ethanol %, TritonX-100 4.2%, the balance is water. Its viscosity is 2.89mPa·s and its surface tension is 38.97mN / m.

[0053] The preparation method is as follows: add 1mL of the above-mentioned nano-zinc powder ink to a clean ink cartridge, install the ink cartridge in an inkjet printer, and use a paraffin crayon to coat paraffin on the filter paper to form a sample adding area on whatman#1 filter paper (i.e. figure 1 The grid in the middle) was melted and infiltrated at 60°C for 5 minutes, and then the above-mentioned nano-zinc powder ink was printed on filter paper and printed 8 times to prepare a fluorescent sensor.

Embodiment 2

[0055] In the present embodiment, the base material of the fluorescent sensor is filter paper No. whatman#1, and the nano-zinc powder ink is made up of the following components by mass percentage: nano-zinc powder 7.8%, ethylene glycol 24.5%, isopropanol 9.5%, ethanol 10.5% %, TritonX-100 1%, the balance is water. Its viscosity is 2.13mPa·s, and its surface tension is 42.86mN / m.

[0056] The preparation method is the same as in Example 1.

Embodiment 3

[0058] In the present embodiment, the base material of the fluorescent sensor is filter paper No. whatman#1, and the nano-zinc powder ink is made up of the following components in mass percentage: nano-zinc powder 3.4%, ethylene glycol 27.5%, isopropanol 8%, ethanol 13.2% %, TritonX-114 3.6%, the balance is water. Its viscosity is 2.67mPa·s and its surface tension is 39.42mN / m.

[0059] The preparation method is the same as in Example 1.

[0060] 2. Contains polyvinyl alcohol

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Abstract

The invention belongs to the field of fluorescent sensors, and particularly relates to a fluorescent sensor and application thereof in determination of niclosamide. The fluorescent sensor comprises asubstrate material and a nanometer metal ink, wherein the nanometer metal ink is sprayed and printed onto the substrate material; the nanometer metal ink is prepared fromcomprises nanometer metal, water, an organic additive and a surfactant, the organic additive is used for adjusting the viscosity and humidity of the ink, and the surfactant is used for adjusting the surface tension of the ink; thenanometer metal can produce hydrogen under the acid condition, and is in a suspension dispersing state in the ink. The fluorescent sensor has the advantages that by fully combining the characteristics and requirements of niclosamide determination means, the niclosamide determination means and methods are redesigned in a targeted way, and the fluorescent sensor with high detection sensitivity, high accuracy and quick and convenient operation is correspondingly developed for determining the niclosamide; the technical problems of large error, low sensitivity, high cost, pollution to environmentand the like in the niclosamide determination process of the prior art are solved.

Description

technical field [0001] The invention belongs to the field of fluorescence sensors, and more specifically relates to a fluorescence sensor and its application in the determination of niclosamide. Background technique [0002] Schistosomiasis is a major infectious disease that seriously endangers the health of our people. Oncomelania is the only intermediate host of schistosomiasis. Eliminating oncomelania is an effective method to prevent and control schistosomiasis. Niclosamide (scientific name 4'-nitro-2', 5-dichlorosalicylanilide) is the only molluscicide recommended by the World Health Organization, and its structural formula is: [0003] [0004] Niclosamide is a light yellow powder with a melting point of 225°C-230°C and a solubility in water of 5-8 mg / L, almost insoluble in water. Niclosamide is highly toxic to non-target organisms such as fish . Due to long-term use, the determination of niclosamide content is particularly important. Existing assay methods mainl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
Inventor 刘敏刘霞
Owner HUAZHONG UNIV OF SCI & TECH
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