762 results about "Re engineering" patented technology

The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible tumor suppressor mir-302 agent into mammalian cells. More particularly, the present invention relates to a method and composition for generating a Tet-On/Off recombinant transgene capable of expressing a manually re-designed mir-302 microRNA (miRNA)/shRNA agent under the control of doxycyclin (Dox) in human somatic/cancer cells and thus inducing certain specific gene silencing effects on the differentiation-associated genes and oncogenes of the cells, resulting in reprogramming the cells into an ES-like pluripotent state.

A helmet mounted display 30 includes a display source 31 arranged to be directly imaged by a primary relay optical arrangement 32 having relay optical elements 33A, 33B and 33C. Light exiting the primary relay optical arrangement 32 indicated by ray traces 34A, 34B and 34C continue towards a visor 35 which is arranged to reflect incident light to a exit pupil located in a convenient position for a viewer 36.

The display source 31 includes a light source, beam splitter, reflective liquid crystal display and a display source relay optical arrangement to provide an output image at an output diffuser screen. The image at the output screen is then directly imaged by the primary relay optical arrangement 32.

Should the reflective liquid crystal display require modification or replacement with a newer model, then the display source 31 can be redesigned to accommodate the new reflective liquid crystal display rather than re-engineering the primary relay optical arrangement 32 at greater expense.

An active down converting supplying a large current consumed when a memory array is active, and a Vpp pump for generating a boosted voltage are configured into active units as cells. A required number of active units are provided depending on the array structure and the operation conditions. A power supply circuit can be redesigned and/or rearranged within a short period for adaptation to change in internal structure for the memory array.

This invention entails the re-design of existing hummingbird feeders that have an upper nectar reservoir with mating base holding the lower nectar reservoir. Please refer to Drawing SKETCH 12006 This is a re-designed hummingbird feeder that lowers the base nectar level approximately one fourth inch (¼″) and out of reach of flying insects, thus eliminating their presence and removing the nuisance and the possibility of painful stings to people. This is a re-designed hummingbird feeder that eliminates the presence of flying insects and their robbing of nectar, thus reducing the expense of nectar.

Apparatus enabling modular implementation of active optical cable (AOC) with multiple integrated functions including: integration of different types of data on the AOC via media conversion; distribution of electrical power over the AOC; electrical multiplexing data channels for optical fibers; integration of voltage regulators enabling AOC operation at different supply voltages; integration of voltage regulators to provide stable, low noise power source; ruggedized, blind-mateable electrical connectors; integration of electronics and optoelectronics inside a connector backshell; implementation of health monitoring and test channel enabling monitoring, test, and control of both ends of the AOC and monitoring and control of upstream systems and components; and enabling a form, fit, function replacement of existing electrical cables to improve SWaP, electromagnetic interference resiliency, length-bandwidth product, electromagnetic pulse resistance, signal integrity, system reliability, testability and maintenance. AOCs are customized for different connectors, pin-outs, electrical data combinations, power distribution and power supplies with minimal redesign/requalification.

The invention discloses an efficient super-resolution method based on a deep back projection network. The method comprises the following steps: (1) obtaining a total training set and a test set; (2) preprocessing the total training set to complete data enhancement; (3) scaling the images in the total training set at different scales; and (4) image super-resolution reconstruction is realized basedon the convolutional neural network, and the convolutional neural network totally comprises 27 convolutional layers and specifically comprises three parts of feature extraction, error back projectionand image reconstruction. The combination of the group convolution and the 1 * 1 convolution is used for replacing the traditional convolution to redesign the iteration submodule, and the strategy caneffectively reduce the model parameter quantity and improve the model efficiency; Each iteration sub-module comprises an error feedback mechanism, so that error correction can be carried out in time;in addition, a channel weighting module is introduced, so that the model efficiency can be further improved.

The present disclosure provides a database and methods to allow users to download and/or upload scanned or raw data for objects from or into a database. The data relating to the objects will be stored in a design file on the database, and will allow for end users to print the objects on a 3D printer at their location. A fee may be charged by a manager of the database. The database will allow for sharing of images between health care providers so that they can reproduce and/or redesign the saved images to produce instruments, cutting guides, models, prosthesis for procedures that are specifically suited for their procedure and patient.

The present invention concerns biologically-active cell-free scaffolds composed of extracts of cellular and/or extracellular compartments for use in tissue regeneration. The present invention also contemplates the novel concept of redesigning the biological scaffold by seeding cells thereon followed by cell elimination. Cells are seeded on the scaffold for a period of time during which a dynamic interaction occurs between the scaffold and the seeded cells, resulting in reshaping of the scaffold architecture and integration of newly synthesized matrix elements. Redesigning may improve the physical and biological characteristics of the scaffold, and also improve the matching of the scaffold to treat a specific target tissue or a specific patient, by seeding tissue-specific cells or by seeding cells which are autologous to a patient, respectively.

Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

In a method for designing a technical system, a technical system is modeled by a predetermined quantity of target functions depending on parameters, each individual target function being weighted with a weighting factor. The method solves a system of equations comprising the parameters and the weighting factors as variables in a variable space, solutions of the system of equations forming working points of a solution space in the variable space. The working points are determined by a predictor-corrector method, according to which a predictor produced by a stochastic variable is determined in the variable space, from a first working point, and a second working point is then determined in a correcting step. The determined working points are used to design the technical system. The method can be used to redesign, modify or adapt an already existing technical system.

A field-programmable object array integrated circuit employs a course gain architecture comprising a core array of highly optimized silicon objects that are individually programmed and synchronously connected via high performance parallel communications structures permitting the user to configure the device to implement a variety of very high performance algorithms. The high level functions available in the objects combined with the unique interconnect structures enables performance superior to existing field programmable solutions while maintaining and enhancing the flexibility. A consistent peripheral “donut” structure around the core of each object makes them interchangeable to build up complex circuits without redesign of standard objects.

The invention discloses a self-adaptive cruise control method based on a safe distance model with driver car-following characteristics, which mainly comprises the following steps: 1, based on the analysis of the motion states between the cars, a safe car-following distance model conforming to the diver car-following characteristics is designed; 2, a fourth-order continuous car-following model of an ACC system is established; 3, the safe car-following distance model established in step 1 is used as the following target of the upper layer decision algorithm of the adaptive cruise system. According to the invention, aiming at the problem that the expected safe distance selected by the upper layer control algorithm of a prior adaptive cruise system does not confirm to the actual driver characteristics, the safe car-following distance model is redesigned and applied to the upper layer decision algorithm, so that the control characteristics of the adaptive cruise system is closer to the control behaviors of a skilled driver and the acceptance and utilization rate of the system are improved.

The invention discloses a bus technology-based universal electromagnetic susceptibility testing device and a bus technology-based universal electromagnetic susceptibility testing method. The testing device comprises a main control computer, a program control testing instrument, a remote control computer and a testing software system. The testing method comprises the following steps of: 1, initializing the universal electromagnetic susceptibility testing device; 2, setting parameters aiming at the electromagnetic susceptibility test by a user; 3, starting an upper level test platform program to start the test; and 4, testing a function generation module-instantiated test function, and testing the electromagnetic susceptibility. The invention overcomes the defect of redesign of the conventional electromagnetic susceptibility testing system when new equipment, the type of a testing bus or the connection mode of the testing instrument needs to be replaced or a testing algorithm needs to be updated, realizes the universal electromagnetic susceptibility testing system with convenient function expansion, addition of node equipment and update of the testing algorithm, and reduces the cost and the energy for system expansion and maintenance.

The invention relates to a PID controller parameter optimizing method, and especially discloses a PID controller optimizing design method based on a particle swarm membrane algorithm. The method comprises that an optimal particle is obtained from a swarm, different dimension values of the particle are successively assigned to to-be-optimized parameters Kp, Ki and Kd, a control system model is operated, performance indexes output by the system are obtained, and it is determined whether the evolution rule is used again to search for the optimal particle so that the optimal control effect can be obtained. The PID controller optimizing design method combines membrane computing with traditional PSO (Particle Swarm Optimization), fully utilizes the partition function and transport communication rules, can obtain a set of more proper PID control parameters, and finally enables a controlled system to achieve the optimal control effect. According the PID controller optimizing design method, the controlled system can obtain the set of more proper PID control parameters and achieves the optimal control effect under the condition that the controller structure is not changed.

The invention discloses a PMSM (Permanent Magnet Synchronous Motor) control method and system. The PMSM control method and system are characterized in that a sliding mode observer for a load torque is designed in a PMSM vector control; compensation is performed by means of integration with slide mode control of a speed ring; redesign is performed on a speed controller; and at the same time, a relatively stable q-axis reference current can be obtained so that relatively ideal rotating speed and torque can be obtained. The PMSM control method and system can quickly and effectively adjust various input and output parameters of the PMSM when the system is interfered, and has the advantages of being high in the dynamic response speed and the robustness, and improving the control accuracy and operational reliability of the PMSM.

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.