766 results about "Re engineering" patented technology

A system for developing, running and analyzing multi-modal applications includes a development platform, a run-time engine, and a data-mining module. Once a mobile application is built and tested on the development platform, it can be automatically deployed on the run-time system, which maintains and manages the application. Further, the data-mining system allows access to reporting and analysis tools that aid in understanding end-user behavior and preferences. This data can be used to further enhance applications by redesigning and redeploying them in a rapid and efficient manner.

The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible tumor suppressor mir-302 agent into mammalian cells. More particularly, the present invention relates to a method and composition for generating a Tet-On / Off recombinant transgene capable of expressing a manually re-designed mir-302 microRNA (miRNA) / shRNA agent under the control of doxycyclin (Dox) in human somatic / cancer cells and thus inducing certain specific gene silencing effects on the differentiation-associated genes and oncogenes of the cells, resulting in reprogramming the cells into an ES-like pluripotent state.

A helmet mounted display 30 includes a display source 31 arranged to be directly imaged by a primary relay optical arrangement 32 having relay optical elements 33A, 33B and 33C. Light exiting the primary relay optical arrangement 32 indicated by ray traces 34A, 34B and 34C continue towards a visor 35 which is arranged to reflect incident light to a exit pupil located in a convenient position for a viewer 36. The display source 31 includes a light source, beam splitter, reflective liquid crystal display and a display source relay optical arrangement to provide an output image at an output diffuser screen. The image at the output screen is then directly imaged by the primary relay optical arrangement 32. Should the reflective liquid crystal display require modification or replacement with a newer model, then the display source 31 can be redesigned to accommodate the new reflective liquid crystal display rather than re-engineering the primary relay optical arrangement 32 at greater expense.

An active down converting supplying a large current consumed when a memory array is active, and a Vpp pump for generating a boosted voltage are configured into active units as cells. A required number of active units are provided depending on the array structure and the operation conditions. A power supply circuit can be redesigned and / or rearranged within a short period for adaptation to change in internal structure for the memory array.

This invention entails the re-design of existing hummingbird feeders that have an upper nectar reservoir with mating base holding the lower nectar reservoir. Please refer to Drawing SKETCH 12006 This is a re-designed hummingbird feeder that lowers the base nectar level approximately one fourth inch (¼″) and out of reach of flying insects, thus eliminating their presence and removing the nuisance and the possibility of painful stings to people. This is a re-designed hummingbird feeder that eliminates the presence of flying insects and their robbing of nectar, thus reducing the expense of nectar.

Apparatus enabling modular implementation of active optical cable (AOC) with multiple integrated functions including: integration of different types of data on the AOC via media conversion; distribution of electrical power over the AOC; electrical multiplexing data channels for optical fibers; integration of voltage regulators enabling AOC operation at different supply voltages; integration of voltage regulators to provide stable, low noise power source; ruggedized, blind-mateable electrical connectors; integration of electronics and optoelectronics inside a connector backshell; implementation of health monitoring and test channel enabling monitoring, test, and control of both ends of the AOC and monitoring and control of upstream systems and components; and enabling a form, fit, function replacement of existing electrical cables to improve SWaP, electromagnetic interference resiliency, length-bandwidth product, electromagnetic pulse resistance, signal integrity, system reliability, testability and maintenance. AOCs are customized for different connectors, pin-outs, electrical data combinations, power distribution and power supplies with minimal redesign / requalification.

A hood assembly for a machine includes an enclosure within which at least one exhaust aftertreatment device is mounted. The engine hood assembly may be preassembled so that the exhaust aftertreatment system is integrated into the enclosure. This may allow the hood assembly to be assembled to the machine and the exhaust aftertreatment system mated to an exhaust pipe from the engine as a unit while the machine is being built on an assembly line. The engine hood assembly may include ventilation openings to assist in heat rejection from the engine compartment and from the exhaust aftertreatment devices. The hood assembly of the present disclosure finds particular application in assisting large track type tractors in meeting ever more stringent exhaust emission requirements without extensive and expensive redesign alternatives.

A hybrid system is combining transaction level modeling (TLM) simulators and hardware accelerators so that new system-on chip (SoC) designs are integrated in a virtual platform (VP) to run TLM simulation and existent semiconductor intellectual properties (IP) are added to physical platform (PP) to run hardware accelerator. A new circuit design with TLM is easier to be performed than with register transfer language (RTL) and it is integrated in a virtual platform and existent IP doesn't have to be redesigned to be integrated in a virtual platform.

System and method include precisely modeling of a facility's energy usage over time based on historic data, and precisely predicting or measuring its actual, reduced energy usage over time after a redesign, retrofit, or renovation, or other positive change to the facility. The energy cost savings, whether over a time point of view (POV) of predicted, real-time, or historic, are creditable to the intervening remediation or renovation of the facility's energy footprint. In accordance with one embodiment, multiple-variable inputs are modeled using arithmetic regression and steepest-descent convergence arithmetic solutions based in large part on building-science (construction) data versus outside average temperature (t) that simplifies the modeling and measurements. Additionality is thus addressed along with a system and method that is more accurate, more repeatable, more reliable, and thus more credible and more readily monetized.

An integrated circuit design has circuit macros made up of device cells. The cells are characterized by determining the leakage current dependency on various process, environmental and voltage parameters. When circuit macros are designed their leakage power is calculated using this data and multi-dimensional models for power and temperature distribution. Circuit macros are identified as timing-critical and timing-noncritical macros. Statistical methods are used to determine the average leakage sensitivities for the specific circuit macros designed. The designer uses the sensitivity data to determine how to redesign selected circuit macros to reduce leakage power. Reducing leakage power in these selected circuits may be used to reduce overall IC power or the improved power margins may be used in timing-critical circuits to increase performance while keeping power dissipation unchanged.

The invention discloses an efficient super-resolution method based on a deep back projection network. The method comprises the following steps: (1) obtaining a total training set and a test set; (2) preprocessing the total training set to complete data enhancement; (3) scaling the images in the total training set at different scales; and (4) image super-resolution reconstruction is realized basedon the convolutional neural network, and the convolutional neural network totally comprises 27 convolutional layers and specifically comprises three parts of feature extraction, error back projectionand image reconstruction. The combination of the group convolution and the 1 * 1 convolution is used for replacing the traditional convolution to redesign the iteration submodule, and the strategy caneffectively reduce the model parameter quantity and improve the model efficiency; Each iteration sub-module comprises an error feedback mechanism, so that error correction can be carried out in time;in addition, a channel weighting module is introduced, so that the model efficiency can be further improved.

A method of making an air boost device, wherein a compressor wheel incorporated therein is re-designed to permit die inserts (20), which occupy the air passage and define the blades (4, 5) during a process of forming a wax pattern (21) of a compressor wheel, to be pulled without being impeded by the blades. This modified blade design enables the automated production of wax patterns (21) using simplified tooling. These wax patterns (21) can be used in a large-scale investment casting process, and produce an economical cast titanium compressor wheel which performs aerodynamically at high boost pressure / RPM.

A redesigned upper receiver for the AR-15 upper receiver has a cylindrical housing, a barrel mount, and a stock mounting point. The barrel mount and the stock mounting point are positioned on opposite ends of the cylindrical housing. The AR-15 gun barrel is connected to the barrel mount. The charge carrier is inserted to the upper receiver through the stock mounting point. The barrel mount has a tubular body, a gas tube slot, a pin locking slot, an internal threading, and an external threading. The radius of the tubular body is larger than the cylindrical housing. The AR-15 gun barrel is secured within the internal threading. The gas tube is inserted to the gas tube slot. The hand guard is threaded onto the external threading of the upper receiver.

The present disclosure provides a database and methods to allow users to download and / or upload scanned or raw data for objects from or into a database. The data relating to the objects will be stored in a design file on the database, and will allow for end users to print the objects on a 3D printer at their location. A fee may be charged by a manager of the database. The database will allow for sharing of images between health care providers so that they can reproduce and / or redesign the saved images to produce instruments, cutting guides, models, prosthesis for procedures that are specifically suited for their procedure and patient.

The invention discloses a refrigerant composition with a low GWP value. The composition consists of 2,3,3,3-tetrafluoropropene(HFO-1234yf), 1,1-difluoroethane (HFC-152a) and dimethyl ether (DME). The preparation method comprises the step of physically mixing the above components at normal temperature in corresponding proportion. The refrigerant composition has zero Ozone-Depletion Potential (ODP), and very low global warming potential (GWP), meets the requirement of environmental protection, has physical property equivalent to HFC-134a, and can be directly used in the traditional HFC-134a system without redesigning a compressor.

The present invention concerns biologically-active cell-free scaffolds composed of extracts of cellular and / or extracellular compartments for use in tissue regeneration. The present invention also contemplates the novel concept of redesigning the biological scaffold by seeding cells thereon followed by cell elimination. Cells are seeded on the scaffold for a period of time during which a dynamic interaction occurs between the scaffold and the seeded cells, resulting in reshaping of the scaffold architecture and integration of newly synthesized matrix elements. Redesigning may improve the physical and biological characteristics of the scaffold, and also improve the matching of the scaffold to treat a specific target tissue or a specific patient, by seeding tissue-specific cells or by seeding cells which are autologous to a patient, respectively.

The statistical analysis described and claimed is a predictive statistical tree model that overcomes several problems observed in prior statistical models and regression analyses, while ensuring greater accuracy and predictive capabilities. Although the claimed use of the predictive statistical tree model described herein is directed to the prediction of a disease in individuals, the claimed model can be used for a variety of applications including the prediction of disease states, susceptibility of disease states or any other biological state of interest, as well as other applicable non-biological states of interest. This model first screens genes to reduce noise, applies k-means correlation-based clustering targeting a large number of clusters, and then uses singular value decompositions (SVD) to extract the single dominant factor (principal component) from each cluster. This generates a statistically significant number of cluster-derived singular factors, that we refer to as metagenes, that characterize multiple patterns of expression of the genes across samples. The strategy aims to extract multiple such patterns while reducing dimension and smoothing out gene-specific noise through the aggregation within clusters. Formal predictive analysis then uses these metagenes in a Bayesian classification tree analysis. This generates multiple recursive partitions of the sample into subgroups (the “leaves” of the classification tree), and associates Bayesian predictive probabilities of outcomes with each subgroup. Overall predictions for an individual sample are then generated by averaging predictions, with appropriate weights, across many such tree models. The model includes the use of iterative out-of-sample, cross-validation predictions leaving each sample out of the data set one at a time, refitting the model from the remaining samples and using it to predict the hold-out case. This rigorously tests the predictive value of a model and mirrors the real-world prognostic context where prediction of new cases as they arise is the major goal.

A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.

In the invention, traffic engineering-link state advertising (TE-LSA) method is adopted to diffuse link state information in traffic engineering by using OSPE flood mechanism. Based on unit triplet (LS Type, Link State ID, advertising Router), LSA is searched in link state database (LSDB), here Link State ID is link index of TE, making each LSA include TE attribute of only one TE router. Comparing with prior art, since TE-Router-LSA is redesigned, the invention makes one to one correspondence between TE router and TE-Router-LSA. Thus, it is not needed to carry out comparison procedure between sequence numbers of TE-Router-LSA and sequence numbers of each TE router existed in TE-Router-LSA of TEDB.

Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

In a method for designing a technical system, a technical system is modeled by a predetermined quantity of target functions depending on parameters, each individual target function being weighted with a weighting factor. The method solves a system of equations comprising the parameters and the weighting factors as variables in a variable space, solutions of the system of equations forming working points of a solution space in the variable space. The working points are determined by a predictor-corrector method, according to which a predictor produced by a stochastic variable is determined in the variable space, from a first working point, and a second working point is then determined in a correcting step. The determined working points are used to design the technical system. The method can be used to redesign, modify or adapt an already existing technical system.

A hood assembly for a machine includes an enclosure within which at least one exhaust aftertreatment device is mounted. The engine hood assembly may be preassembled so that the exhaust aftertreatment system is integrated into the enclosure. This may allow the hood assembly to be assembled to the machine and the exhaust aftertreatment system mated to an exhaust pipe from the engine as a unit while the machine is being built on an assembly line. The engine hood assembly may include ventilation openings to assist in heat rejection from the engine compartment and from the exhaust aftertreatment devices. The hood assembly of the present disclosure finds particular application in assisting large track type tractors in meeting ever more stringent exhaust emission requirements without extensive and expensive redesign alternatives.

A field-programmable object array integrated circuit employs a course gain architecture comprising a core array of highly optimized silicon objects that are individually programmed and synchronously connected via high performance parallel communications structures permitting the user to configure the device to implement a variety of very high performance algorithms. The high level functions available in the objects combined with the unique interconnect structures enables performance superior to existing field programmable solutions while maintaining and enhancing the flexibility. A consistent peripheral “donut” structure around the core of each object makes them interchangeable to build up complex circuits without redesign of standard objects.

The invention discloses a self-adaptive cruise control method based on a safe distance model with driver car-following characteristics, which mainly comprises the following steps: 1, based on the analysis of the motion states between the cars, a safe car-following distance model conforming to the diver car-following characteristics is designed; 2, a fourth-order continuous car-following model of an ACC system is established; 3, the safe car-following distance model established in step 1 is used as the following target of the upper layer decision algorithm of the adaptive cruise system. According to the invention, aiming at the problem that the expected safe distance selected by the upper layer control algorithm of a prior adaptive cruise system does not confirm to the actual driver characteristics, the safe car-following distance model is redesigned and applied to the upper layer decision algorithm, so that the control characteristics of the adaptive cruise system is closer to the control behaviors of a skilled driver and the acceptance and utilization rate of the system are improved.

The invention discloses a bus technology-based universal electromagnetic susceptibility testing device and a bus technology-based universal electromagnetic susceptibility testing method. The testing device comprises a main control computer, a program control testing instrument, a remote control computer and a testing software system. The testing method comprises the following steps of: 1, initializing the universal electromagnetic susceptibility testing device; 2, setting parameters aiming at the electromagnetic susceptibility test by a user; 3, starting an upper level test platform program to start the test; and 4, testing a function generation module-instantiated test function, and testing the electromagnetic susceptibility. The invention overcomes the defect of redesign of the conventional electromagnetic susceptibility testing system when new equipment, the type of a testing bus or the connection mode of the testing instrument needs to be replaced or a testing algorithm needs to be updated, realizes the universal electromagnetic susceptibility testing system with convenient function expansion, addition of node equipment and update of the testing algorithm, and reduces the cost and the energy for system expansion and maintenance.

The invention relates to a PID controller parameter optimizing method, and especially discloses a PID controller optimizing design method based on a particle swarm membrane algorithm. The method comprises that an optimal particle is obtained from a swarm, different dimension values of the particle are successively assigned to to-be-optimized parameters Kp, Ki and Kd, a control system model is operated, performance indexes output by the system are obtained, and it is determined whether the evolution rule is used again to search for the optimal particle so that the optimal control effect can be obtained. The PID controller optimizing design method combines membrane computing with traditional PSO (Particle Swarm Optimization), fully utilizes the partition function and transport communication rules, can obtain a set of more proper PID control parameters, and finally enables a controlled system to achieve the optimal control effect. According the PID controller optimizing design method, the controlled system can obtain the set of more proper PID control parameters and achieves the optimal control effect under the condition that the controller structure is not changed.

The invention discloses a PMSM (Permanent Magnet Synchronous Motor) control method and system. The PMSM control method and system are characterized in that a sliding mode observer for a load torque is designed in a PMSM vector control; compensation is performed by means of integration with slide mode control of a speed ring; redesign is performed on a speed controller; and at the same time, a relatively stable q-axis reference current can be obtained so that relatively ideal rotating speed and torque can be obtained. The PMSM control method and system can quickly and effectively adjust various input and output parameters of the PMSM when the system is interfered, and has the advantages of being high in the dynamic response speed and the robustness, and improving the control accuracy and operational reliability of the PMSM.