Mussaenda pubescens extract and preparation and application thereof in treating nephritis

A technology of jade leaf golden flower and extract, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effect of short course of treatment, good therapeutic effect and remarkable effect

Inactive Publication Date: 2018-06-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of Jade Yejinhua extract in Chinese medicine composition to treat nephritis has not been reported yet.

Method used

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  • Mussaenda pubescens extract and preparation and application thereof in treating nephritis
  • Mussaenda pubescens extract and preparation and application thereof in treating nephritis
  • Mussaenda pubescens extract and preparation and application thereof in treating nephritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Jade Leaf Golden Flower Extract

[0032] Follow the steps below:

[0033] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing an 80-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0034] (2) According to the ratio of Yuye Jinhua powder and isopropanol aqueous solution at a ratio of 1:10, reflux extraction at the azeotropic point of 88-92°C for 100 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0035] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:10, soak for 30 minutes at a temperature of 40°C, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2000MHz, microwave The power is 400W, the extraction time is 3min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the extract of Jad...

Embodiment 2

[0036] Example 2 Preparation of Jade Leaf Golden Flower Extract

[0037] Follow the steps below:

[0038] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 100-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0039] (2) According to the ratio of Yuyejinhua powder and isopropanol aqueous solution at a ratio of 1:20, reflux extraction at the azeotropic point of 88-92°C for 200 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0040] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:20, soak at 42°C for 45 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2570MHz, microwave The power is 500W, the extraction time is 5min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the extract of Jade Leaf Golden Flow...

Embodiment 3

[0041] Example 3 Preparation of Jade Leaf Golden Flower Extract

[0042] Follow the steps below:

[0043] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 120 mesh sieve to obtain Jade Leaf Golden Flower powder;

[0044] (2) According to the ratio of Yuyejinhua powder and isopropanol aqueous solution of 1:30, reflux extraction at the azeotropic point of 88-92°C for -300min, filter, concentrate under reduced pressure, and collect fractions;

[0045] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:30, warm soak at 45°C for 30-60min, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction condition is microwave frequency 2000 -3000MHz, microwave power 600W, extraction time 7min, separate liquid, collect organic phase, remove ethyl acetate-butyl acetate solvent by rotary evaporation under reduced pressure, and obtain Jade Leaf Golden Flower extract with a density of 1.17.

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Abstract

The invention provides a mussaenda pubescens extract and preparation and application thereof in treating nephritis. A preparation method of the mussaenda pubescens extract comprises the steps that mussaenda pubescens is dried and smashed to obtain mussaenda pubescens powder; the mussaenda pubescens powder and an isopropanol aqueous solution are mixed, the mixture is subjected to refluxing, filtering and concentration, and fractions are collected; pure water is added into the fractions, warm maceration, ethyl acetate-butyl acetate microwave extraction and liquid separation are conducted, an organic phase is collected, rotary evaporation is performed to remove a solvent, and the mussaenda pubescens extract is obtained. Atractylodes macrocephala koidz, radix astragali, Sarigaridi, rhizoma atractylodis and ligustrazine are smashed, mixed, decocted, filtered and concentrated to obtain an anti-inflammatory composition water extract; the diluted mussaenda pubescens extract is added, and solidpowder is obtained after spray drying. The mussaenda pubescens extract has a remarkable nephritis treating effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction technology and application, in particular to the extract of Jade Leaf Golden Flower and its preparation, in particular to the application of the extract in treating nephritis. Background technique [0002] Glomerulonephritis, also known as nephritic syndrome (referred to as nephritis), is a common kidney disease, which refers to a disease that occurs in the glomeruli of both kidneys due to various reasons, and is clinically manifested as a group of syndromes. The common manifestations of glomerulonephritis (may not appear at the same time): edema, proteinuria, hematuria, hypertension, decreased urine output or anuria, and normal or decreased renal function. Clinically commonly used hormones and immunosuppressants (such as cyclophosphamide, mycophenolate mofetil, tacrolimus, cyclosporine A), others include blood pressure control drugs, diuretics, anti-platelet aggregation drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P13/12A61K31/4965
CPCA61K36/74A61K31/4965A61K36/284A61K36/481A61K2236/331A61K2236/333A61K2236/55A61K2300/00
Inventor 赵立春
Owner GUANGXI UNIV OF CHINESE MEDICINE
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