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Applications of compound Sorbicillin in preventing and treating candida albicans

A Candida albicans and compound technology, applied in the field of biomedicine, can solve problems such as research on the compound sorbicillin that has never been seen before, and achieve the effect of promoting development, low toxicity and promoting development

Inactive Publication Date: 2018-07-31
SOUTH CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In 1948, Cram isolated the compound sorbicillin from Penicillium notatum for the first time. The structure of this compound is unique and changeable. Due to its various biological activities, many scientific and technical workers are concerned about its synthesis mechanism, synthesis method and activity. A lot of research has been done, but there is no detailed research and report on the compound sorbicillin in the field of prevention and treatment of Candida albicans

Method used

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  • Applications of compound Sorbicillin in preventing and treating candida albicans
  • Applications of compound Sorbicillin in preventing and treating candida albicans
  • Applications of compound Sorbicillin in preventing and treating candida albicans

Examples

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Embodiment 1

[0020] The fermentation extraction of embodiment 1 actinomycetes bacterial strain and the preparation of compound sorbicillin

[0021] The actinomycete strain SCSIOT05 was isolated from the seabed sediments (E94°3364′, S1°4256′) at 4617m in the Indian Ocean, and the 16SrDNA gene sequence analysis confirmed that the strain was Streptomyces olivaceusSCSIO T05. The gene sequence was saved to GenBank (accession number MF429815).

[0022] The strain Streptomyces olivaceus SCSIOT05 grown on ISP2 solid medium was inoculated into 1L Erlenmeyer flasks (10 flasks) containing 200mL ISP2 liquid medium, and the culture medium was fermented on a shaker, and fermented at 28°C and 200rpm for two days to obtain seeds. The seeds were inoculated and fermented in a 65L fermenter containing 40LRA medium, and the culture conditions were as follows: temperature 28°C, rotational speed 200rpm, sterile air 20L / min, pressure 0.1Mpa. Sampling 50mL every 12h, butanone extraction and HPLC detection to obs...

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Abstract

The invention belongs to the field of biological medicine, and more specifically relates to applications of compound Sorbicillin in preventing and treating candida albicans, and more specifically applications of the compound Sorbicillin in preparation of drugs used for preventing and treating infective diseases caused by candida albicans. Compared with the prior art, the beneficial effects are that: technology disclosed in the invention is capable of realizing success preparation and screening of compound Sorbicillin capable of inhibiting candida albicans adhesiveness, mycelia form transition,and the pathogenicity. The Sorbicillin is low in toxicity, candida albicans and human cell growth are not influenced, and it is promising to promote development of novel antifungal drug treatment.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of compound sorbicillin in preventing and treating Candida albicans. Background technique [0002] Candida albicans (Candida albicans) is a common conditional pathogen. When the human body's immunity is weakened, it will cause disease, and it will cause superficial and deep infection, and even threaten life. The drugs currently on the market for the treatment of Candida albicans are mainly azoles and polyenes, but these drugs have shortcomings such as narrow antibacterial spectrum and high toxicity to varying degrees; in addition, with the development of antifungal drugs The drug resistance of Candida albicans has become more and more prominent due to the long-term and large-scale use. Therefore, the development of new compounds against Candida albicans has become the first step in the research and development of antifungal drugs. [0003] Existing studies...

Claims

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Application Information

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IPC IPC(8): A61K31/12C12P7/26A61P31/10C12R1/58
CPCA61K31/12C12P7/26
Inventor 邓音乐鞠建华蒙丽丽孙长利赵朔孙秀云陈俐
Owner SOUTH CHINA AGRI UNIV
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