Applications of compound Sorbicillin in preventing and treating candida albicans

A Candida albicans and compound technology, applied in the field of biomedicine, can solve problems such as research on the compound sorbicillin that has never been seen before, and achieve the effect of promoting development, low toxicity and promoting development

Inactive Publication Date: 2018-07-31
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AI-Extracted Technical Summary

Problems solved by technology

[0005] In 1948, Cram isolated the compound sorbicillin from Penicillium notatum for the first time. The structure of this compound is unique and changeable. Due to its various biological activities, many scientific and technical workers are...
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The invention belongs to the field of biological medicine, and more specifically relates to applications of compound Sorbicillin in preventing and treating candida albicans, and more specifically applications of the compound Sorbicillin in preparation of drugs used for preventing and treating infective diseases caused by candida albicans. Compared with the prior art, the beneficial effects are that: technology disclosed in the invention is capable of realizing success preparation and screening of compound Sorbicillin capable of inhibiting candida albicans adhesiveness, mycelia form transition,and the pathogenicity. The Sorbicillin is low in toxicity, candida albicans and human cell growth are not influenced, and it is promising to promote development of novel antifungal drug treatment.

Application Domain

AntimycoticsMicroorganism based processes +2

Technology Topic

DrugToxicity +10


  • Applications of compound Sorbicillin in preventing and treating candida albicans
  • Applications of compound Sorbicillin in preventing and treating candida albicans
  • Applications of compound Sorbicillin in preventing and treating candida albicans


  • Experimental program(1)
  • Effect test(1)

Example Embodiment

[0020] Example 1 Fermentation extraction of actinomycete strains and preparation of compound sorbicillin
[0021] Actinomycetes strain SCSIOT05 was isolated from the bottom sediments (E94°3364', S1°4256') of the Indian Ocean 4617m. The 16SrDNA gene sequence analysis confirmed that the strain was Streptomyces olivaceusSCSIO T05. The gene sequence was saved in GenBank (accession number MF429815).
[0022] The strain Streptomyces olivaceus SCSIOT05 grown on the ISP2 solid medium was inoculated into a 1L Erlenmeyer flask (10 flasks) containing 200 mL of ISP2 liquid medium, and the medium was shaken for fermentation. The seeds were fermented at 28° C. and 200 rpm for two days. The seeds were inoculated in a 65L fermentor containing 40LRA medium for fermentation and culture. The culture conditions were 28°C, 200rpm, sterile air 20L/min, and pressure 0.1Mpa. 50mL was sampled every 12h, butanone was extracted and tested by HPLC to observe the fermentation.
[0023] Among them, the composition of ISP2 solid medium is: 4.0g/L glucose, 4.0g/L yeast extract powder, 10g/L malt extract powder, 30g/L sea salt, 20g/L agar powder, adjust the pH value to 7.4. The composition of RA medium is: 10g/L glucose, 10g/L malt extract powder, 5.0g/L corn flour, 20g/L soluble starch, 10g/L maltose, 2.0g/L CaCO 3 , 30g/L sea salt, adjust the pH to 7.4.
[0024] After 3 days of fermentation, the bacteria were harvested, centrifuged, the mycelium was extracted three times with acetone and concentrated under reduced pressure to obtain an extract (245mg); the supernatant was extracted three times with butanone and concentrated under reduced pressure to obtain an extract (12.1g). According to HPLC analysis As a result, the two parts of the extract were combined, silica gel column chromatography, chloroform-methanol (100:0, 95:5, 90:10, 85:15, 80:20, 70:30, 50:50) eluted to obtain Fr. There are 7 parts in 1-Fr.7, and the medium-pressure Rp-18 reversed-phase column chromatography in part Fr.2 (30:70→100:0, 0→120min), acetonitrile-water elution, to obtain Fr.2-1 to Fr.2-5 five parts, Fr.2-2 part semi-preparative column chromatography, acetonitrile-water elution (5:5→10:0, 0→30min), to obtain the compound sorbicillin (5.0mg, Rf=19.01min ). The structure of the compound is analyzed by mass spectrometry and 1 H. 13 CNMR data and comparison with literature (Zhao P.J., et al. Chem. Biodivers. 2006, 3:337-342) confirmed.
[0025] Example 2 Effect detection test


no PUM

Description & Claims & Application Information

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