Metal coordination supramolecular hydrogel and preparation method thereof

A supramolecular hydrogel and metal coordination technology, applied in the field of polymer materials, can solve the problems of complex preparation process and long gelation time, and achieve the effect of cheap raw materials, simple operation and great application prospects

Inactive Publication Date: 2018-08-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, the gelation time of supramolecular hydrogels is relativ...

Method used

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  • Metal coordination supramolecular hydrogel and preparation method thereof
  • Metal coordination supramolecular hydrogel and preparation method thereof
  • Metal coordination supramolecular hydrogel and preparation method thereof

Examples

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preparation example Construction

[0027] The invention provides a method for preparing a metal-coordination supramolecular hydrogel, comprising the following steps:

[0028] a), chondroitin sulfate sodium salt and iron salt are cross-linked in water to obtain metal coordination supramolecular hydrogel.

[0029] In the method provided by the invention, directly chondroitin sulfate sodium salt (abbreviation CS) and Fe 3+ The metal coordination supramolecular hydrogel can be obtained by cross-linking in water. Wherein, the iron salt includes but not limited to ferric chloride; the Fe in the chondroitin sulfate sodium salt, iron salt 3+ The consumption ratio with water is preferably (1~5) mmol: 1mmol: (2~15) mL, more preferably (2~4) mmol: 1 mmol: (3~10) mL; the chondroitin sulfate sodium salt and Fe in iron salt 3+ The molar ratio of concrete can be 1:1, 2:1, 3:1 or 4:1; Fe in the described iron salt 3+ The amount ratio with the water can specifically be 1mmol: 3mL, 1mmol: 3.67mL, 1mmol: 4mL, 1mmol: 5mL, 1mmo...

Embodiment 1

[0042] CS solution and FeCl 3 solution according to CS and Fe 3+ Mixed at a molar ratio of 1:1, the pH of the mixed system was 9, shaken at 37°C for 5s, and cross-linked to obtain CS-Fe 3+ Hydrogels.

[0043] For the prepared CS-Fe 3+ The hydrogel was observed by scanning electron microscope (SEM), and the results were as follows: figure 1 as shown, figure 1 It is the SEM image of the hydrogel provided by Example 1 of the present invention. pass figure 1 It can be seen that the cross-linking of the monomers forms a hydrogel with a pore size of about 50 μm.

[0044] 1 mL of the above CS-Fe prepared 3+ The hydrogel is loaded into the syringe, the plunger is pushed, and the results are as follows figure 2 as shown, figure 2 It is the hydraulic injectability test diagram provided by Example 1 of the present invention, wherein (a) is during the piston pushing process, and (b) is after complete extrusion. pass figure 2 It can be seen that the CS-Fe prepared in this examp...

Embodiment 2

[0049] CS solution and FeCl 3 solution according to CS and Fe 3+ Mix at a molar ratio of 2:1, the pH of the mixed system is 9, shake at 37°C for 5s, and cross-link to prepare CS-Fe 3+ Hydrogels.

[0050] For the prepared CS-Fe 3+ The hydrogel is tested for adhesion, and the result is compared with Example 1, the adhesion is poor, not enough to support the given pulling force of the load of 210g, injectability, self-healing ability, and viscoelasticity are not different Big.

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Abstract

The invention belongs to the field of high molecular materials and in particular relates to metal coordination supramolecular hydrogel and a preparation method thereof. The preparation method providedby the invention comprises the following step: a) crosslinking sodium chondroitin sulfate and iron salt in water to obtain the metal coordination supramolecular hydrogel. The sodium chondroitin sulfate and Fe<3+> are used as raw materials and are cross-linked in the water to form the supramolecular hydrogel. The method provided by the invention is simple to operate and rapid in gel formation speed; the raw materials are green, environmentally friendly and cheap; an organic solvent and expensive instruments and equipment are not needed in a preparation process; the prepared supramolecular hydrogel has very good adhesion and can be injected; the supramolecular hydrogel can be self-healed at room temperature, without the need of a healing promoting agent or stimulation of other external conditions; furthermore, the Fe<3+> has a certain bleeding stopping function, so that the supramolecular hydrogel prepared by the preparation method can be clinically applied to a wound closure device, ahemostatic agent and a tissue sealing agent to control blood loss and promote tissue healing; therefore, the supramolecular hydrogel has a very great application prospect in the aspect of self healingof wounds.

Description

technical field [0001] The invention belongs to the field of polymer materials, in particular to a metal coordination supramolecular hydrogel and a preparation method thereof. Background technique [0002] Hydrogel can be defined as a three-dimensional network polymer that absorbs water and swells, and can retain a large amount of water without dissolving. Since Wichterle and Lim synthesized the first cross-linked poly(hydroxyethyl methacrylate) hydrogel in 1960, the hydrogel has good swelling properties, permeability, biocompatibility and non-deactivation of drug loading. , It has been widely used in the fields of daily chemical products, environmental engineering, food engineering and biomedicine. [0003] According to the different formation methods of the three-dimensional network structure of hydrogel, it can be divided into chemical hydrogel and physical hydrogel. Chemical hydrogel is formed by chemical cross-linking between molecules, which has the advantages of sta...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08J3/075C08K3/16
CPCC08J3/075C08J2305/08C08K3/16
Inventor 谭帼馨张凤苗代聪周蕾周正难
Owner GUANGDONG UNIV OF TECH
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