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Application of phenylpyruvic acid in preparation of products for relieving or improving anxiety and depression behaviors

A technology of phenylpyruvic acid and products, applied in the field of medicine, can solve the problems of shortening, adverse effects, etc., and achieve the effects of less addition, safe and easy acquisition, and high physiological activity

Inactive Publication Date: 2018-08-21
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the deficiencies of the current mainstream market antidepressants and drugs for improving learning and memory, and to provide a new method of phenylpyruvate in the preparation of anti-anxiety, anti-depression and / or drugs or health products for improving learning and memory. While widening the scope of application of phenylpyruvate, it can significantly alleviate the anxiety and depression levels of patients with affective mental disorders, shorten their learning time for things, and improve the level of spatial memory ability. The application of anti-depression and improving the level of learning and memory ability provides a strong technical theoretical basis, and on the other hand, it also solves the problem of adverse effects of anti-anxiety, antidepressant drugs and drugs that improve learning and memory ability

Method used

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  • Application of phenylpyruvic acid in preparation of products for relieving or improving anxiety and depression behaviors
  • Application of phenylpyruvic acid in preparation of products for relieving or improving anxiety and depression behaviors
  • Application of phenylpyruvic acid in preparation of products for relieving or improving anxiety and depression behaviors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Effect of adding phenylpyruvate to common diet on anxiety behavior of mice (open field test, OFT)

[0050] 1. In order to study the effect of phenylpyruvate on the anxiety behavior of mice, C57BL / 6J male mice were used as the research object, divided into 3 groups (control group and two treatment groups), reared in a single cage, and the number of repetitions was 8. Mice were fed with normal diet supplemented with 0% (control group), 0.2% and 0.4% phenylpyruvate, respectively, and the open field test was carried out four weeks later.

[0051] 2. Effects of adding phenylpyruvate to common diet on anxiety behavior of mice

[0052] (1) The specific test method is:

[0053] The experimental animals were transported to the special temporary cages for the behavioral laboratory in advance, and they were adapted to the environment for about 3 hours to reduce the tension of the animals; the mice were taken out of the cages (the mice were facing away from the experimen...

Embodiment 2

[0056] Example 2 Effect of adding phenylpyruvate to common diet on anxiety behavior of mice (elevated plus maze test, elevated plus-maze, EPM)

[0057] 1. In order to expand the data and deeply study the effect of phenylpyruvate on the anxiety behavior of mice, the experiment took C57BL / 6J male mice as the research object, divided into 3 groups (control group and two treatment groups), reared in single cage, repeated The mice were fed with normal diets supplemented with 0% (control group), 0.2% and 0.4% phenylpyruvate, respectively. After four weeks, the open field test was performed, followed by the elevated plus maze test every other week.

[0058] 2. Effects of adding phenylpyruvate to common diet on anxiety behavior of mice (elevated plus maze test)

[0059] (1) The specific test method is:

[0060] The experimental animals were transported to the special temporary cages in the behavioral laboratory in advance, and they were adapted to the environment for about 3 hours to...

Embodiment 3

[0063] Example 3 Effects of adding phenylpyruvate to common diets on depressive behavior in mice (Tail suspension test, TST)

[0064] 1. In order to expand the data and deeply study the effect of phenylpyruvate on the anxiety behavior of mice, the experiment took C57BL / 6J male mice as the research object, divided into 3 groups (control group and two treatment groups), reared in single cage, repeated 8, the mice were fed with normal diets supplemented with 0% (control group), 0.2% and 0.4% phenylpyruvate, respectively. After four weeks, the open field test was performed, followed by the elevated plus maze test every other week, and then every other week. Perform tail suspension test.

[0065] 2. Effects of adding phenylpyruvate to common diet on depressive behavior of mice

[0066] (1) The specific test method is:

[0067] The operator used non-adhesive glue to suspend the 1 / 3 of the tail tip of the mouse in the tail-suspension box, so that the head was facing the camera and ...

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Abstract

The invention discloses application of phenylpyruvic acid in preparation of products for relieving or improving anxiety and depression behaviors. The invention provides new application of phenylpyruvic acid or its pharmaceutically acceptable salts or phenylpyruvic acid prodrugs in preparation of products for preventing, alleviating and / or treating affective mental disorder diseases, or improving learning and memory dysfunction. The invention provides a powerful technical theoretical basis for application of phenylpyruvic acid in the aspects of resisting anxiety, resisting depression, and improving the learning and memory ability level, and on the other hand also solves the problems of adverse effects in anti-anxiety and anti-depression drugs and drugs for improving learning and memory ability. Moreover, the adding amount of phenylpyruvic acid is small, phenylpyruvic acid can be directly added into animal drinking water, feed, food or drugs, has the advantages of safety, effectiveness,no cause of toxic and side effects and the like, and has good popularization and application prospects in resisting anxiety, resisting depression, and improving the learning and memory ability level.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of phenylpyruvate in the preparation of drugs, food or health products for anti-anxiety, anti-depression and / or improving learning and memory ability. Background technique [0002] Anxiety disorder, also known as anxiety neurosis, is one of the more common mental illnesses. Unfavorable psychological hints, the influence of environmental factors or genetic factors are all reasons why people suffer from anxiety disorders. There are six major harms caused by depression and anxiety: 1. Easy insomnia and suicide; 2. Loss of working ability; 3. Economic loss; 4. Shortened life span; Some researchers have found that anxiety-related lack of sleep can last up to 6 months; moreover, excessive anxiety can also increase the incidence of cancer; in addition, anxiety and depression are often accompanied by progressive decline in brain function, the most direc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P25/22A61P25/24A61P25/28A23L33/10
CPCA23L33/10A23V2002/00A61K31/192A61P25/22A61P25/24A61P25/28A23V2200/322A23V2250/02
Inventor 束刚江青艳廖正睿袁业现王丽娜王松波
Owner SOUTH CHINA AGRI UNIV
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