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Stable triprolidine hydrochloride-containing oral solution agent and preparation method thereof

A technology of triprolidine hydrochloride and oral solution, applied in the field of pharmaceutical preparations, can solve problems such as poor stability and easy breeding of bacteria, and achieve the effects of high stability, improving medication safety and preventing microbial growth

Inactive Publication Date: 2018-08-24
NANJING GRITPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product of the invention has controllable quality and high stability, simple process, easy absorption, definite curative effect, better meets clinical needs, and can solve the problems of poor stability and easy breeding of bacteria in commercially available products

Method used

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  • Stable triprolidine hydrochloride-containing oral solution agent and preparation method thereof
  • Stable triprolidine hydrochloride-containing oral solution agent and preparation method thereof
  • Stable triprolidine hydrochloride-containing oral solution agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]

[0025]

[0026] Preparation Process:

[0027] 1. Weigh citric acid and sodium citrate into 300ml purified water, stir to dissolve, then add triprolidine hydrochloride and stir to dissolve;

[0028] 2. Add sorbitol, potassium sorbate and stevia in turn to the above solution and stir to dissolve respectively;

[0029] 3. Add glycerin, propylene glycol, and orange flavor to the above 2 solutions and stir to mix evenly;

[0030] 4. Dilute to a sufficient volume with purified water, then filter;

[0031] 5. The pH value of the final solution is 5.01.

Embodiment 2

[0033] Raw materials

[0034] The preparation process is the same as in Example 1, and the pH of the final solution is 4.98.

Embodiment 3

[0036] Raw materials

[0037] The preparation process is the same as in Example 1, and the pH of the final solution is 5.08.

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PUM

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Abstract

The invention discloses a stable triprolidine hydrochloride-containing oral solution agent and a preparation method thereof, and belongs to the field of medicine preparations. The oral solution is used for treating diseases such as allergy, common cold and rhinitis. The triprolidine hydrochloride-containing oral solution preparation has the advantages that the medicine use safety is higher; the bitter taste is reduced; the stable triprolidine hydrochloride-containing oral solution agent is particularly suitable for children to use. The oral solution preparation has the pH being 4 to 7, so thatthe stability of the preparation is higher.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an oral solution preparation containing triprolidine. Background technique [0002] Allergic diseases are generally characterized by immediate allergic reactions, also known as type I allergic reactions, which mainly cause allergic rhinitis, asthma, conjunctivitis, eczema, food allergies, drug allergies, and severe allergic reactions. In the past few decades, the incidence of allergic diseases has increased significantly, which has seriously affected the quality of life of children and adults, and even endangered their lives. It has become a public health issue of global concern. [0003] Immunoglobulin E (IgE) is an antibody that mediates type I allergic reactions. There are two types of IgE receptors in the human body: the high-affinity receptor FcεRI and the low-affinity receptor FcεRII, the former expressed in mast cells and basophils, the latter expressed in B cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4439A61K47/46A61K47/12A61P11/02A61P37/08A61P11/00
CPCA61K9/0095A61K31/4439A61K47/12A61K47/46A61P11/00A61P11/02A61P37/08
Inventor 何红燕朱飞耿聪聪张慧周静赵卿霍立茹李战
Owner NANJING GRITPHARMA CO LTD
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