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Levonorgestrel vagina expansion bolt and preparation method thereof

A vaginal expansive suppository and levonorgestrel technology, which is applied in suppository delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as female rejection, obvious vaginal stimulation, and superposition of side effects, and improve Self-healing ability, reducing friction and dryness, and increasing the effect of proportion

Inactive Publication Date: 2018-08-28
霍尔果斯汉智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] CN105796572A discloses a contraceptive drug and a preparation method thereof. It is a prescription of contraceptive hormone and contraceptive chemical drug, that is, oral contraceptives and external contraceptives are used in combination to avoid stimulating the gastrointestinal tract and reduce dosage, but multiple contraceptives are used comprehensively, The side effects are superimposed, the stimulation to the vagina is obvious, and it is easy to cause female rejection
CN101288660A discloses a kind of levonorgestrel drop pill and preparation method thereof, and innovates the dosage form of levonorgestrel, but the drop pill is still an oral contraceptive, and the disadvantages brought by oral medicine still exist

Method used

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  • Levonorgestrel vagina expansion bolt and preparation method thereof
  • Levonorgestrel vagina expansion bolt and preparation method thereof
  • Levonorgestrel vagina expansion bolt and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053]

[0054] Preparation:

[0055] (1) Preparation of drug-containing matrix:

[0056] a) mixing each component in the matrix in a water bath according to the formula amount to obtain an oil phase;

[0057] b) dispersing the mixed solution containing levonorgestrel and glycoprotein gel as the water phase in the oil phase of step a) to obtain a pre-emulsion;

[0058] c) performing rapid membrane emulsification on the pre-emulsion obtained in step (b) to obtain a drug-containing matrix;

[0059] (2) Pour the drug-containing matrix into a suppository mold, insert an expansion carrier, attach and shape it, and prepare a suppository.

Embodiment 2

[0061]

[0062] The preparation method is the same as in Example 1.

Embodiment 3

[0064]

[0065] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides a vagina expansion bolt and a preparation method and application thereof. The expansion bolt comprises levonorgestrel, glycoprotein gel, a medium and an expandable expansion carrier. The expansion bolt further comprises lactobacillus, hyaluronic acid and vitamins. According to the vagina expansion bolt, the use amount of levonorgestrel is reduced, the side effect of levonorgestrel is reduced, the penetrating resistance of sperms is improved at the same time, the contraception efficiency can be effectively improved, the use comfort degree is high, and the vagina expansionbolt has the effect of nourishing the vagina.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and relates to a vaginal expansion suppository and a preparation method thereof, in particular to a levonorgestrel vaginal expansion suppository and a preparation method thereof. Background technique [0002] Existing contraceptive methods include condoms, birth control pills, tubal ligation, and intrauterine devices. Chinese women mainly use contraceptives for contraception, including oral contraceptives and external contraceptives. Oral contraceptives are administered orally. The drug enters the blood through the gastrointestinal digestive system, and then reaches the target organs and target cells through the body fluid circulation, inhibits ovarian ovulation, promotes cervical mucus to thicken and hinders sperm penetration, and changes the activity mode of the uterus and fallopian tubes. Interfering with the implantation of pregnant eggs, etc. Oral contraceptives are formulated with art...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/567A61K35/747A61K31/375A61K47/42A61K47/36A61K47/22A61P15/18
CPCA61K9/0034A61K9/02A61K31/375A61K31/567A61K35/747A61K47/22A61K47/36A61K47/42A61K2300/00
Inventor 林淼
Owner 霍尔果斯汉智医药科技有限公司
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