Application of ursodesoxycholic acid

A technology of ursodeoxycholic acid and medicinal salts, applied in the field of medicine, to achieve the effects of avoiding abnormalities, improving diffuse thyroid enlargement, and broad application prospects

Inactive Publication Date: 2018-08-28
胡晨波 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there are no published reports on the use of ursodeoxycholic acid in the treatment of thyroid disease

Method used

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  • Application of ursodesoxycholic acid
  • Application of ursodesoxycholic acid
  • Application of ursodesoxycholic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Case 1 was a 52-year-old female patient who was diagnosed with "fatigue for one month" and was diagnosed after further examination: 1. Primary biliary cholangitis 2. Hashimoto's thyroiditis. Oral administration of 0.25 grams of ursodeoxycholic acid (trade name: Ursifer), three times a day, orally 1 hour after meals, after the patient took the medicine for more than 3 months, TPOAB and TGAB were significantly lower than before taking the medicine, see the table below for details 1. It can be seen from the results in Table 1 that taking ursodeoxycholic acid can effectively reduce the levels of TPOAB and TGAB antibodies in patients with Hashimoto's thyroiditis.

[0020] Table 1 TPOAB, TGAB antibody levels before and after taking the medicine in case 1 patient

[0021]

Embodiment 2

[0023] Case 2, a 43-year-old female patient, went to the doctor because of "fatty liver and thyroid nodules found in physical examination". Diagnosis: 1. Fatty liver 2. Hashimoto's thyroiditis. Oral administration of ursodeoxycholic acid (trade name: Ursifer) 0.25 g, three times a day, orally 1 hour after meals, after the patient took the medicine continuously for more than 3 months, TPOAB and TGAB were significantly lower than before taking the medicine, and the number of thyroid nodules Compared with before taking the medicine, it was significantly reduced, as shown in Table 2 below. It can be seen from the results in Table 2 that taking ursodeoxycholic acid can not only effectively reduce the levels of TPOAB and TGAB antibodies in patients with Hashimoto's thyroiditis, but also significantly reduce the thyroid nodules.

[0024] Table 2 Changes of TPOAB and TGAB antibody levels and thyroid nodules before and after taking the medicine in patient 2

[0025]

Embodiment 3

[0027] Case 3, a 43-year-old female patient, went to see a doctor because of "abnormal liver function found in physical examination for 1 month." After further examination, the diagnosis was: 1. Hepatitis 2. Hashimoto's thyroiditis. Oral administration of ursodeoxycholic acid (trade name: Ursifer) 0.25 g, three times a day, orally 1 hour after meals, after taking the medicine for more than 3 months, TPOAB and TGAB were significantly lower than before taking the medicine, and the thyroid nodules subsided , the patient continued to take the medicine for one year and changed to oral ursodeoxycholic acid (trade name: Ursifer) 0.25 grams, twice a day, orally 1 hour after meals. After 3 and a half years of treatment, no obvious abnormalities were found in the B-ultrasound examination of the thyroid gland. TPOAB and TGAB returned to normal, see Table 3 below for details. From the results in Table 3, it can be seen that taking ursodeoxycholic acid can significantly reduce thyroid nodu...

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Abstract

The invention discloses the application of ursodesoxycholic acid or isomers, derivatives, medicinal salts or prodrug molecules thereof to preparation of medicines for treating and / or preventing thyroid diseases. The invention further discloses a pharmaceutical composition comprising the ursodesoxycholic acid. The ursodesoxycholic acid disclosed by the invention can achieve clinical effects of effectively lowering levels of thyroid peroxidase antibodies and thyroglobulin antibodies of patients suffering from hashimoto thyroiditis, obviously reducing thyroid nodules, improving diffuse swelling of the thyroid gland, avoiding abnormal thyroid functions and preventing thyroid cancer, is expected to become a drug for treating clinical thyroid diseases and has a very wide application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new application of ursodeoxycholic acid. Background technique [0002] At present, thyroid disease is very common. According to data, 9% to 15% of adult women suffer from thyroid disease to varying degrees, and the proportion is relatively low among men. Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, is a common thyroid disease in clinical practice, and its occurrence is the result of the joint action of genetic and environmental factors. Diagnosis of Hashimoto’s thyroiditis In addition to thyroid ultrasound showing diffuse thyroid enlargement or thyroid nodules, 95% of Hashimoto’s thyroiditis patients have increased levels of thyroid peroxidase antibody (TPOAB), and 60% to 80% of Hashimoto’s thyroiditis Patients with thyroiditis have elevated levels of thyroglobulin antibody (TGAB). [0003] In patients with Hashimoto's thyroiditis, lymphocytes and ...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K45/06A61K33/18A61P5/14A61P35/00
CPCA61K31/575A61K33/18A61K45/06A61K2300/00
Inventor 胡晨波
Owner 胡晨波
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