A pharmaceutical composition for purifying Salmonella in breeders

A composition, Salmonella technology, applied in the directions of drug combinations, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as limited protective efficacy, and achieve the effects of reducing horizontal transmission, protecting liver cells, and improving intestinal mucosal structure.

Active Publication Date: 2021-05-04
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vaccination is an ideal way to control Salmonella infection. However, due to the large number of Salmonella serotypes, the existing inactivated vaccines and attenuated vaccines for specific serotypes have very limited protective effects, and new broad-spectrum and high-efficiency vaccines are still under study. middle

Method used

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  • A pharmaceutical composition for purifying Salmonella in breeders
  • A pharmaceutical composition for purifying Salmonella in breeders
  • A pharmaceutical composition for purifying Salmonella in breeders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The formula of the pharmaceutical composition of purifying breeder Salmonella of the present invention is:

[0030] 30 parts by weight of baicalin flavone, 20 parts by weight of L-lysine, and 30 parts by weight of L-arginine.

[0031] Wherein, the preparation method of Scutellaria baicalensis is:

[0032] (1) Extraction of Scutellaria baicalensis flavonoids: crush the decoction pieces of Scutellaria baicalensis, pass through an 80-mesh sieve, add 5 times the weight of medicinal materials and 50% dimethyl sulfoxide solution, extract twice at 40°C for 60 minutes each time, filter, and combine the filtrates, spare.

[0033] (2) Membrane separation: the filtrate obtained in step (1) is subjected to membrane separation, and the membrane separation conditions are: select 10nm inorganic ceramic membrane, flow rate is 1.5L / min, pressure 0.12MPa and feed liquid temperature 30°C, to obtain Scutellaria baicalensis Concentrate.

[0034] (3) Spray drying: the baicalin flavone con...

Embodiment 2

[0038] The formula of the pharmaceutical composition of purifying breeder Salmonella of the present invention is:

[0039] 35 parts by weight of Scutellaria baicalensis, 30 parts by weight of L-lysine, and 35 parts by weight of L-arginine.

[0040] The preparation method of baicalin flavonoids is the same as in Example 1.

[0041] According to the prescription proportion, 35 kg of baicalin flavonoids, 30 kg of L-lysine and 35 kg of L-arginine were weighed, mixed evenly and subpackaged to obtain a pharmaceutical composition for purifying Salmonella chicken breeder.

Embodiment 3

[0043] The formula of the pharmaceutical composition of purifying breeder Salmonella of the present invention is:

[0044] 50 parts by weight of baicalin flavone, 40 parts by weight of L-lysine, and 50 parts by weight of L-arginine.

[0045] The preparation method of baicalin flavonoids is the same as in Example 1.

[0046] According to the prescription ratio, 50 kg of baicalin flavones, 40 kg of L-lysine, and 50 kg of L-arginine are weighed, mixed evenly, and packaged separately to obtain a pharmaceutical composition for purifying Salmonella chicken breeder.

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Abstract

The invention provides a pharmaceutical composition for purifying Salmonella of breeder chickens. The raw materials are calculated in parts by weight: 30-50 parts of baicalin flavonoids, 20-40 parts of L-lysine, and 30-50 parts of L-arginine . The pharmaceutical composition of the present invention can not only effectively inhibit and kill Salmonella, but also can reduce the horizontal spread of Salmonella in breeders and the bacterial contamination of breeding eggs caused by potential endogenous displacement by regulating the immune defense of breeder chickens, and purify Salmonella in breeder chickens. Improve the production performance of breeders and egg hatching performance, reduce maternal infection, and ensure the health of chicks.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a pharmaceutical composition for purifying Salmonella in breeders. Background technique [0002] Food safety issues caused by foodborne pathogens have been paid more and more attention, among which Salmonella is one of the pathogens that are very important to poultry production and public health. Chicken salmonellosis is a common and frequently-occurring disease caused by Salmonella. Young chickens are characterized by high morbidity and mortality. Adult chickens are mostly infected with slow / recessive processes, but they often induce endogenous infections and become horizontal. and vertical transmission of infection. In recent years, due to provenance pollution, frequent cases of pullorum and high mortality in chicks have occurred frequently, which has brought huge economic losses to commercial chicken farmers. The "National Medium and Long-Term Animal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K36/539A61P31/04A61P15/08
CPCA61K31/198A61K36/539A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P15/08A61P31/04A61K2300/00
Inventor 崔东安王胜义王磊王慧王俊宝徐润强
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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