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Collagen coating on porous titanium surface and preparation method thereof

A technology of collagen and porous titanium, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problems of long time for new bone formation on the surface and unfavorable biological stability of implants, so as to improve biocompatibility and Tissue repair ability, high spraying efficiency, simple and convenient process

Active Publication Date: 2020-09-15
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Titanium alloy material is a biologically inert material, which usually cannot chemically bond with bone tissue like bioactive materials. It takes a long time for new bone to form on its surface, which is not conducive to the biological stability of implants.

Method used

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  • Collagen coating on porous titanium surface and preparation method thereof
  • Collagen coating on porous titanium surface and preparation method thereof
  • Collagen coating on porous titanium surface and preparation method thereof

Examples

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Embodiment 1

[0026] As an embodiment of the preparation method of the collagen coating on the porous titanium surface of the present invention, the preparation method of the collagen coating on the porous titanium surface described in this embodiment comprises the following steps:

[0027] (1) Sample pretreatment: Use acetone, ethanol, and pure water to ultrasonically clean the micro-arc oxidation porous titanium alloy in sequence. Each reagent is washed 3 times for 10 minutes each time, and dried in a vacuum oven after cleaning.

[0028] (2) Collagen solution preparation: Hexafluoroisopropanol was used as a solvent to prepare a collagen solution, the mass fraction of collagen in the collagen solution was 0.5%, the collagen molecular weight was 360 kDa, and magnetic stirring was carried out at room temperature for 3 hours.

[0029] (3) Electrostatic spraying: transfer the dissolved collagen solution to a 20mL syringe, replace the electrospinning needle, and fix it on the injector. Adjust t...

Embodiment 2

[0031] As an embodiment of the preparation method of the collagen coating on the porous titanium surface of the present invention, the preparation method of the collagen coating on the porous titanium surface described in this embodiment comprises the following steps:

[0032] (1) Sample pretreatment: Use acetone, ethanol, and pure water to ultrasonically clean the micro-arc oxidation porous titanium alloy in sequence. Each reagent is washed 3 times for 10 minutes each time, and dried in a vacuum oven after cleaning.

[0033] (2) Collagen solution preparation: Hexafluoroisopropanol was used as a solvent to prepare a collagen solution, the mass fraction of collagen in the collagen solution was 1%, the molecular weight of collagen was 270 kDa, and magnetic stirring was carried out at room temperature for 3 hours.

[0034] (3) Electrostatic spraying: transfer the dissolved collagen solution to a 20mL syringe, replace the electrospinning needle, and fix it on the injector. Adjust ...

Embodiment 3

[0036] As an embodiment of the preparation method of the collagen coating on the porous titanium surface of the present invention, the preparation method of the collagen coating on the porous titanium surface described in this embodiment comprises the following steps:

[0037] (1) Sample pretreatment: Use acetone, ethanol, and pure water to ultrasonically clean the micro-arc oxidation porous titanium alloy in sequence. Each reagent is washed 3 times for 10 minutes each time, and dried in a vacuum oven after cleaning.

[0038] (2) Collagen solution preparation: Hexafluoroisopropanol was used as a solvent to prepare a collagen solution, the mass fraction of collagen in the collagen solution was 2%, the molecular weight of collagen was 300 kDa, and magnetic stirring was carried out at room temperature for 3 hours. (3) Electrostatic spraying: transfer the dissolved collagen solution to a 20mL syringe, replace the electrospinning needle, and fix it on the injector. Adjust the volta...

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Abstract

The invention discloses a porous titanium surface collagen coating and a preparation method thereof. The method provided by the invention adopts electrostatic spraying technique to prepare a collagencoating on a porous titanium alloy surface, conducts bioactivation modification on the titanium alloy surface, and improves the biocompatibility and tissue repair ability of the titanium alloy material. The collagen coating clings to a porous titanium alloy skeleton in a bead form, also can coexist with a porous titanium alloy surface micro-arc oxidation structure, and realizes complementation ofthe advantages of the two technologies. At the same time, the biological evaluation test result indicates that the collagen coating prepared by the method provided by the invention can meet the requirements of implantable medical devices.

Description

technical field [0001] The invention relates to the technical field of biomedical coatings, in particular to a collagen coating on a porous titanium surface and a preparation method thereof. Background technique [0002] Titanium alloy material is a kind of biologically inert material, which usually cannot chemically bond with bone tissue like bioactive materials. It takes a long time for new bone to form on its surface, which is not conducive to the biological stability of implants. Therefore, it is necessary to carry out biological activation modification treatment on the surface of titanium alloy. The general idea is to generate organic (such as protein, enzyme, etc.) or inorganic (such as hydroxyapatite, titanium dioxide, etc.) bioactive coating on the surface of titanium alloy, mainly including Three types: physical modification method, chemical modification method and biochemical method. [0003] Collagen composite technology on the surface of titanium alloy is anothe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/56A61L27/50
CPCA61L27/06A61L27/34A61L27/50A61L27/56A61L2400/18C08L89/00
Inventor 陈鹏罗思施李奕恒
Owner GUANGZHOU TRAUER BIOTECH
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