Guaiacane-type sesquiterpene a, preparation method thereof, and application as preparation of preventive and antitumor drugs
A technology of guaiacane and sesquiterpene, which is applied in the direction of antineoplastic drugs, applications, and drug combinations, and can solve problems such as large adverse reactions of therapeutic drugs, threats to human life, and medical problems that plague medical workers.
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Embodiment 1
[0024] Example 1: The (+)-Guaia-l(10),4(5),ll-triene-3-one-9β-hydroxy, the chemical structural formula is
[0025]
[0026] The (+)-Guaia-1(10), 4(5), 11-triene-3-one-9β-hydroxy described in this example was carried out by proton nuclear magnetic resonance spectrum ( 1 H-NMR) and carbon nuclear magnetic resonance ( 13 C-APT) analysis, (+)-Guaia-l(10), 4(5), ll-triene-3-one-9β-hydroxy described in this example 1 H-NMR spectrum as figure 2 As shown, the (+)-Guaia-l(10), 4(5), ll-triene-3-one-9β-hydroxy described in the examples 13 C-APT spectrum as image 3 shown, yes figure 2 and image 3 To analyze the spectrum, the figure 2 and image 3 The peaks are assigned, figure 2 and image 3 The peak assignments are shown in Table 2. pass figure 2 , image 3 And the data in Table 1 shows that the chemical structural formula of (+)-Guaia-1(10), 4(5), 11-triene-3-one-9β-hydroxy described in this embodiment is as follows figure 1 As shown, the (+)-Guaia-l(10),4(5),ll-...
Embodiment 2
[0027]Example 2: The (+)-Guaia-l(10), 4(5), ll-triene-3-one-9β-hydroxy is obtained according to the following method: the first step is to crush the root of Chamaejasma chamaejas Sieve and add methanol, soak at room temperature for 3 hours to 4 hours, heat and reflux extraction at 50°C to 60°C for 3 times, each time for 1 hour to 3 hours, combine each reflux extract, recover under reduced pressure, and concentrate , to obtain the total extract of Tianshan chamaejasma; in the second step, after dispersing the total extract of Tianshan chamaejasma with water into a suspension, sequentially extract with petroleum ether, chloroform, ethyl acetate, and n-butanol, and extract Concentrate to obtain the petroleum ether part extract; the third step, get the petroleum ether part extract and obtain 8 fractions after gradient elution with silica gel column chromatography, wherein, the silica gel column chromatography gradient eluent includes chloroform and methanol, chloroform and methanol...
Embodiment 3
[0028] Example 3: The (+)-Guaia-l(10), 4(5), ll-triene-3-one-9β-hydroxy is obtained according to the following method: the first step is to crush the root of Chamaejasma chamaejas Sieve and add methanol, soak at room temperature for 3 hours or 4 hours, heat and reflux extraction at 50°C or 60°C for 3 times, each time for 1 hour or 3 hours, combine each reflux extract, recover under reduced pressure, and concentrate , to obtain the total extract of Tianshan chamaejasma; in the second step, after dispersing the total extract of Tianshan chamaejasma with water into a suspension, sequentially extract with petroleum ether, chloroform, ethyl acetate, and n-butanol, and extract Concentrate to obtain the petroleum ether part extract; the third step, get the petroleum ether part extract and obtain 8 fractions after gradient elution with silica gel column chromatography, wherein, the silica gel column chromatography gradient eluent includes chloroform and methanol, chloroform and methano...
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