A Fracture Healing Simulation System Based on Mechanical Stimulation and Biological Combined Stimulation

A fracture healing and simulation system technology, applied in the field of biomedical engineering, can solve the problem of oversimplification of fracture healing area models and material property settings, no establishment of joint regulation of mechanical factors and biological factors, no deterministic relationship between differentiation and apoptosis To achieve the effect of reducing delayed healing, improving the quality of fracture healing, and shortening the training period

Inactive Publication Date: 2019-10-25
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. There is no individualized model specifically for patients;
[0005] 2. The joint regulation of mechanical factors and biological factors has not been established;
[0006] 3. There is no definite relationship between mechanical factors and cell proliferation, differentiation and apoptosis;
[0007] 4. The model and material property settings of the fracture healing area are too simplified

Method used

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  • A Fracture Healing Simulation System Based on Mechanical Stimulation and Biological Combined Stimulation
  • A Fracture Healing Simulation System Based on Mechanical Stimulation and Biological Combined Stimulation
  • A Fracture Healing Simulation System Based on Mechanical Stimulation and Biological Combined Stimulation

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specific Embodiment approach 1

[0030] Specific implementation manner one: such as figure 1 As shown, the fracture healing simulation system based on mechanical stimulation and biological combined stimulation according to this embodiment includes:

[0031] Fracture area analysis model establishment module 1, fracture area mechanical regulation modeling module 2, fracture area biological regulation modeling module 3, fracture area force-biological joint regulation modeling module 4, and program termination judgment module 5;

[0032] Fracture area analysis model 1 establishment module is used to establish the fracture area geometric model and finite element model;

[0033] The fracture area mechanical control modeling module 2 is used to model the mechanical characteristics of the fracture area, and solve the mechanical stimulation of the fracture area unit;

[0034] The fracture area biological regulation modeling module 3 is used to model the biological characteristics of the fracture area, and solve the cell concen...

specific Embodiment approach 2

[0038] Specific implementation manner two: such as Figure 1-5 As shown, in this embodiment, the specific process for the fracture area analysis model establishment module 1 to realize its functions is as follows:

[0039] 1) The establishment of a three-dimensional surface geometric model of the fracture area;

[0040] Use the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the image surface, and obtain the 3D surface geometric model through the process of threshold filtering, interactive segmentation and 3D reconstruction;

[0041] The image is obtained by the imaging device CT, and the data storage format is DICOM;

[0042] 2) Establishment of finite element model of fracture area;

[0043] Mesh the three-dimensional surface geometric model of the fracture area, discretize the continuous geometric model, and obtain the finite element model of the fracture area;

[0044] The meshing includes two steps: surface meshing and volume meshing: the surface ...

specific Embodiment approach 3

[0049] Specific implementation manner three: such as Figure 1-5 As shown, in this embodiment, the specific process for the fracture zone mechanical regulation modeling module 2 to realize its function is as follows:

[0050] 1) Apply an external load on the finite element model of the fracture area, and set the boundary and initial conditions;

[0051] The magnitude of the external load is determined by the force that the bone bears, and the applied load is different for different experimental objects;

[0052] The boundary and initial conditions are obtained from CT image information;

[0053] 2) Regarding the fracture area as a dual-phase poroelastic model, obtain the constitutive equation, balance equation and geometric equation of the fracture area element from the poroelastic theory, and calculate the distortion strain D and fluid flow velocity V of the fracture area element by the finite element method , The specific process is:

[0054] a. Constitutive equation

[0055]

[0056]...

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Abstract

The invention provides a bone fracture healing simulation system based on mechanical and biological joint adjustment and control and relates to the field of biomedical engineering. The system comprises a bone fracture area analysis model establishing module, a bone fracture area mechanical adjustment and control modeling module, a bone fracture area biological adjustment and control modeling module, a bone fracture area mechanical and biological joint adjustment and control modeling module and a program determination judging module. The bone fracture area analysis model establishing module isused for establishing a bone fracture area geometrical model and a finite element model. The bone fracture area mechanical adjustment and control modeling module is used for solving mechanical simulation exerted to a bone fracture area unit. The bone fracture area biological adjustment and control modeling module is used for related cell concentration, growth factor concentration and extracellularmatrix concentration. The bone fracture area mechanical and biological joint adjustment and control modeling module is used for achieving joint adjustment and control of mechanical and biological simulation. The program determination judging module is used for judging program determination. The bone fracture healing simulation system provides beneficial help for finding of the bone fracture healing schemes by simulating the bone fracture healing process.

Description

Technical field [0001] The invention relates to the field of biomedical engineering, in particular to a fracture healing simulation system based on mechanical stimulation and biological combined stimulation. Background technique [0002] Fracture is a common trauma. The high incidence of fracture makes the research on the mechanism of fracture healing and the promotion of fracture healing particularly urgent. Unlike other tissue injuries, fractures do not rely on fibrous connective tissue connection, but complete regeneration of bone tissue. Nevertheless, not all fractures can heal completely, and sometimes delayed union or even nonunion occurs. Delayed union or non-union of fractures can cause pain and dysfunction in the affected limb, leading to unemployment, and thus a great social and economic burden. Therefore, although the research on fracture healing has always attracted much attention, 5%-10% of fractures still have delayed union or even nonunion due to various reasons....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/50G06F17/50
CPCG06F30/23G06F2119/06G16H50/50
Inventor 王沫楠杨宁
Owner HARBIN UNIV OF SCI & TECH
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