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Chlorine dioxide solution used for oral administration

A chlorine dioxide and solution technology, applied in the digestive system, chlorine active ingredients, dispersion liquid delivery, etc., can solve problems such as poor cure rate, health hazards, and normal intestinal flora imbalance

Active Publication Date: 2018-09-14
宁波科瑞特动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, drugs are mainly used for prevention and treatment. Among the selected drugs, chemical drugs such as quinolones, aminoglycosides and sulfonamides are the main ones. Due to long-term irregular drug use in veterinary clinics, a large number of drug-resistant bacteria have emerged in clinical practice. The effect of these commonly used chemical drugs is poor, and the cure rate is not good, leading to the imbalance of normal flora in piglet stomach and intestinal tract, drug resistance and drug residues and other side effects, which bring harm to the health of animal organisms and livestock product consumers

Method used

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  • Chlorine dioxide solution used for oral administration

Examples

Experimental program
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Effect test

preparation example Construction

[0052] The preparation method of the modified diatomite loaded with chlorine dioxide comprises the following steps:

[0053] (1) Calcinate the diatomite in a muffle furnace at 450°C for 2h, cool to room temperature, soak it in a 70°C water bath for 4h with a sulfuric acid solution with a mass fraction of 70%, dilute it with deionized water, filter, and washed with deionized water several times until the filtrate is neutral, dried under reduced pressure at 70°C for 24 hours, and ground to obtain the treated diatomite; the diatomite and the sulfuric acid solution with a mass fraction of 70%, the deionized The weight ratio of ionized water (for dilution) is 1:6:20;

[0054] (2) Add absolute ethanol to the diatomite treated in step (1), stir at room temperature for 1 h, then add glycerol hydroxystearate, heat up to 70°C, keep the temperature for 2h, cool down to room temperature, filter, 70°C Drying under reduced pressure for 20 hours, grinding to obtain glycerol hydroxystearate ...

Embodiment 1

[0064] The chlorine dioxide solution for oral administration includes A component and B component, and the A component includes at least Scutellaria baicalensis extract, Forsythia extract, Dandelion extract, Cortex Phellodendri extract, Atractylodes macrocephala extract, Cortex Moutan extract, Poria cocos extract, plantago seed extract, ephedra extract, yam extract, Codonopsis pilosula extract, licorice extract, cinnamon extract; the B component includes modified diatomaceous earth loaded with chlorine dioxide , deionized water; the weight ratio of the A component to the B component is 1:16; the weight ratio of the modified diatomite loaded with chlorine dioxide in the B component to the deionized water is 1:45; the preparation raw material of modified diatomite in the modified diatomite loaded with chlorine dioxide at least includes diatomite, glycerol hydroxystearate, chitosan-guanidine salt complex; The weight ratio of the diatomite to the glycerol hydroxystearate and the c...

Embodiment 2

[0074] The chlorine dioxide solution for oral administration includes A component and B component, and the A component includes at least Scutellaria baicalensis extract, Forsythia extract, Dandelion extract, Cortex Phellodendri extract, Atractylodes macrocephala extract, Cortex Moutan extract, Poria cocos extract, plantago seed extract, ephedra extract, yam extract, Codonopsis pilosula extract, licorice extract, cinnamon extract; the B component includes modified diatomaceous earth loaded with chlorine dioxide , deionized water; the weight ratio of the A component to the B component is 1:10; the weight ratio of the modified diatomite loaded with chlorine dioxide in the B component to the deionized water is 1:45; the preparation raw material of modified diatomite in the modified diatomite loaded with chlorine dioxide at least includes diatomite, glycerol hydroxystearate, chitosan-guanidine salt complex; The weight ratio of the diatomite to the glycerol hydroxystearate and the c...

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Abstract

The invention provides a chlorine dioxide solution used for oral administration. The chlorine dioxide solution used for oral administration comprises an A component and a B component; the A componentat least comprises radix scutellariae extract product, Fructus Forsythiae extract product, dandelion extract product, phellodendron extract product, bighead atractylodes rhizome extract product, treepeony bark extract product, Poria cocos extract product, Plantain seed extract product, ephedra stem extract product, Chinese yam extract product, Radix Codonopsis extract product, licorice extract product, and cortex cinnamomi extract product; and the B component comprises modified diatomite loaded with chlorine dioxide, and deionized water.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a chlorine dioxide solution for oral administration. Background technique [0002] Intestinal diarrhea in livestock and poultry is a common disease in livestock and poultry. Taking pigs as an example, its symptoms include viral infections, infectious gastrointestinal diseases, epidemic diarrhea, swine fever, pseudorabies, etc. In addition, there are parasitic diarrhea, roundworm, ginger worm, nutritional deficiency and metabolic disorder or poisoning factors can also cause diarrhea. In recent years, the incidence of porcine epidemic diarrhea is particularly high, and piglets aged 1-3 months are more Common, the incidence of epidemic diarrhea in piglets after weaning is as high as 30%-40%, and the mortality rate is as high as 30%-50%. Especially the morbidity and mortality of suckling pigs are higher, nearly 100%. After the pigs are sick, they grow slowly and the rate...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P1/12A61K33/20
CPCA61K9/0095A61K33/20A61K36/076A61K36/17A61K36/284A61K36/288A61K36/344A61K36/484A61K36/539A61K36/54A61K36/634A61K36/65A61K36/68A61K36/71A61K36/756A61K36/8945A61P1/12A61K2300/00
Inventor 黄珊珊郭瑞忠施明华王亚佩
Owner 宁波科瑞特动物药业有限公司
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