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Method for preparing tocopherol succinate, and heating system

A technology of tocopheryl succinate and heating system, which is applied in the direction of steam generation method, steam generation, lighting and heating equipment, etc., which can solve the problem of loss of function, no longer having vitamin E biological activity, vitamin E product preparation, and inconvenient storage And other issues

Pending Publication Date: 2018-09-14
JIANGSU CONAT BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Since the hydroxyl group on the mother ring of vitamin E chroman is easily oxidized, it no longer has the biological activity of vitamin E and loses its function, which brings a lot of inconvenience to the preparation and storage of vitamin E products.

Method used

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  • Method for preparing tocopherol succinate, and heating system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Select synthetic tocopherol (the purity of tocopherol is 99.8%), add succinic anhydride (addition is added according to 2.5 times of the molar weight of tocopherol), then add pyridine (addition is that every kilogram of synthetic tocopherol adds 80ml), then at 45 The reaction was carried out at ℃ for 2.5h to obtain the crude product of natural tocopherol succinate.

[0027] The prepared crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 7ml / g, and crystallized at 4°C for 20h.

[0028] It is calculated that the yield of the whole reaction is 96.8%, the esterification rate is 96.23%, the reaction process is mild and efficient, and the purity is 99.02% (yield=actual yield / theoretical yield).

Embodiment 2

[0030] Select synthetic tocopherol (the purity of tocopherol is 99.8%), add succinic anhydride (addition is added according to 2.5 times of the molar weight of tocopherol), then add pyridine (addition is that every kilogram of synthetic tocopherol adds 90ml), then at 50 The reaction was carried out at ℃ for 2 hours to obtain the crude product of natural tocopherol succinate.

[0031] The prepared crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 7ml / g, and crystallized at 3°C ​​for 18h.

[0032] After calculation, the yield of the whole reaction is 95.6%, the esterification rate is 95.89%, the reaction process is mild and efficient, and the purity is 98.07% (yield=actual yield / theoretical yield).

Embodiment 3

[0034] Select synthetic tocopherol for use (tocopherol purity is 99.8%), add succinic anhydride (addition is added according to 2.5 times of the molar weight of tocopherol), then add pyridine (addition is that every kilogram of synthetic tocopherol adds 100ml), then at 40 The reaction was carried out at ℃ for 2.5h to obtain the crude product of natural tocopherol succinate.

[0035] The prepared crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 6ml / g, and crystallized at 4°C for 18h.

[0036] After calculation, the yield of the whole reaction is 95.0%, the esterification rate is 96.08%, the reaction process is mild and efficient, and the purity is 98.67% (yield=actual yield / theoretical yield).

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Abstract

The invention discloses a method for preparing tocopherol succinate, and a heating system. The method comprises the following steps: carrying out pretreatment, specifically, adding acetone into a rawmaterial containing natural tocopherol, and treating for 40-45h at -20 to -17 DEG C to obtain the pretreated raw material; preparing, specifically, adding succinic anhydride and pyridine into the pretreated raw material, carrying out a reaction at 40-50 DEG C for 2-3h by means of the heating system to obtain a crude product of natural tocopheryl succinate; crystallizing, specifically, crystallizing the crude product of the natural tocopheryl succinate with n-hexane. In the preparation process, almost no tocopherol is lost; furthermore, the method is high in whole reaction yield, esterificationrate and purity, mild and efficient in reaction conditions, and in line with the concept of green chemistry.

Description

technical field [0001] The invention belongs to the technical field of tocopherol deep processing, and in particular relates to a method for preparing tocopherol succinate and a heating system thereof. Background technique [0002] Since the hydroxyl group on the parent ring of vitamin E chroman is easily oxidized, it no longer has the biological activity of vitamin E, and its function is lost, which brings a lot of inconvenience to the preparation and storage of vitamin E products. [0003] Nowadays, the deep processing of vitamin E mainly focuses on the modification of the 6-position phenolic hydroxyl group on the mother ring of tocopherol. The esterification reaction can effectively protect the phenolic hydroxyl group to avoid the oxidation of free vitamin E. Common vitamin E ester derivatives include tocopheryl acetate, tocopheryl succinate, tocopheryl nicotinate, and tocopheryl vitamin A ester , tocopherol vitamin C ester, tocopherol polyethylene glycol ester, etc. The...

Claims

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Application Information

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IPC IPC(8): C07D311/72F22B1/00F22B31/08
CPCC07D311/72F22B1/00F22B31/08
Inventor 陈其林吴正章方华郭春荣张鹏
Owner JIANGSU CONAT BIOLOGICAL PROD
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