2-phenylpyridine dual-core palladium (II) complex and preparing method and application thereof

A technology of phenylpyridine and complex, applied in the field of 2-phenylpyridine binuclear palladium complex and preparation thereof, can solve the problems of side effects, large cytotoxicity, drug resistance and the like in patients, and achieve good potential medicinal value , significant in vitro antitumor activity and cytotoxicity selectivity
CN108558952AActive Publication Date: 2018-09-21YULIN NORMAL UNIVERSITY
3 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YULIN NORMAL UNIVERSITY
Publication Date
2018-09-21

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a 2-phenylpyridine dual-core palladium (II) complex. The structural formula of the complex can be seen in the description. The invention further discloses a preparing method ofthe 2-phenylpyridine dual-core palladium (II) complex. The method includes the steps of evenly mixing glacial acetic acid, palladium acetate and 2-phenylpyridine, conducting complete reaction under stirring and heating, conducting cooling to the room temperature, removing glacial acetic acid to obtain reddish brown liquid, adding a polarity solvent, and conducting standing until yellow crystals are separated out thoroughly to obtain the 2-phenylpyridine dual-core palladium (II) complex. The invention further discloses application of the 2-phenylpyridine dual-core palladium (II) complex. The 2-phenylpyridine dual-core palladium (II) complex has remarkable in-vitro antineoplastic activity and cytotoxicity selectivity and is simple in preparing method and easy to industrially produce.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a binuclear metal complex, in particular to a 2-phenylpyridine binuclear palladium (II) complex and a preparation method and application thereof. Background technique

[0002] With the rapid development of my country's social economy, industrialization, urbanization and aging are intensifying, population growth, lifestyle changes, and the incidence of cancer among residents is on the rise. At this time, the study of anticancer drugs and their mechanism of action on genetic material has very important theoretical value and practical significance.

[0003] Cisplatin has been widely used in cancer chemotherapy since it was discovered in the 1970s that it can inhibit the growth of tumor cells, and it occupies a very important position in chemotherapy drugs. Cisplatin anticancer drugs have the characteristics of broad anticancer spectrum, strong effect, and synergistic effect with various anticancer drugs. First-line drugs, especi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More