2-phenylpyridine dual-core palladium (II) complex and preparing method and application thereof

A technology of phenylpyridine and complex, applied in the field of 2-phenylpyridine binuclear palladium complex and preparation thereof, can solve the problems of side effects, large cytotoxicity, drug resistance and the like in patients, and achieve good potential medicinal value , significant in vitro antitumor activity and cytotoxicity selectivity

Active Publication Date: 2018-09-21
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cisplatin anticancer drugs have high cytotoxicity, and patients receiving treatment will have side effects, and drug resistance will gradually develop during treatment

Method used

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  • 2-phenylpyridine dual-core palladium (II) complex and preparing method and application thereof
  • 2-phenylpyridine dual-core palladium (II) complex and preparing method and application thereof
  • 2-phenylpyridine dual-core palladium (II) complex and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0029] (2) Heating and stirring the mixed solution, allowing it to fully react at 100° C. for 24 h, then cooling to room temperature, removing the solvent, and obtaining a small amount of reddish-brown liquid.

[0030] (3) Add 3.0mL of methanol and 2.0mL of chloroform to the reddish-brown liquid and let it stand for 34 days until the yellow crystals are completely precipitated to obtain the 2-phenylpyridine dinuclear palladium (II) complex with a yield of 98.3% .

[0031] (4) The yellow crystal separated out is subjected to infrared spectroscopy (see figure 1 ), X-ray single crystal diffraction (see figure 2 ) and elemental analysis (see Table 2) determination. Infrared spectrum IR (KBr): 1680cm ...

Embodiment 2

[0035] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0036] (2) Heating and stirring the mixed solution, allowing it to fully react at 60° C. for 70 h, then cooling to room temperature, and removing the solvent to obtain a small amount of reddish-brown liquid.

[0037] (3) Add 92mL of ethanol and 2mL of acetone into the reddish-brown liquid and let it stand for 34 days until the yellow crystals are completely precipitated to obtain the 2-phenylpyridine dinuclear palladium(II) complex with a yield of 85.0%.

[0038] (4) The precipitated yellow crystals were subjected to the same measurement as in Example 1, and the measurement results were the same as those in Example 1. It was determined that the yellow crystals were 2-phenylpyridine binuclear palladium ...

Embodiment 3

[0040] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0041] (2) Heating and stirring the mixed solution, allowing it to fully react at 135° C. for 10 h, cooling to room temperature, and removing the solvent to obtain a small amount of reddish-brown liquid.

[0042] (3) Add 50 mL of ethanol and 3 mL of dichloromethane into the reddish-brown liquid, and let it stand for 34 days until the yellow crystals are completely precipitated to obtain 2-phenylpyridine binuclear palladium (II) complex with a yield of 90.0%.

[0043] (4) The precipitated yellow crystals were subjected to the same measurement as in Example 1, and the measurement results were the same as those in Example 1. It was determined that the yellow crystals were 2-phenylpyridine binuclear pallad...

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Abstract

The invention discloses a 2-phenylpyridine dual-core palladium (II) complex. The structural formula of the complex can be seen in the description. The invention further discloses a preparing method ofthe 2-phenylpyridine dual-core palladium (II) complex. The method includes the steps of evenly mixing glacial acetic acid, palladium acetate and 2-phenylpyridine, conducting complete reaction under stirring and heating, conducting cooling to the room temperature, removing glacial acetic acid to obtain reddish brown liquid, adding a polarity solvent, and conducting standing until yellow crystals are separated out thoroughly to obtain the 2-phenylpyridine dual-core palladium (II) complex. The invention further discloses application of the 2-phenylpyridine dual-core palladium (II) complex. The 2-phenylpyridine dual-core palladium (II) complex has remarkable in-vitro antineoplastic activity and cytotoxicity selectivity and is simple in preparing method and easy to industrially produce.

Description

technical field [0001] The invention relates to a binuclear metal complex, in particular to a 2-phenylpyridine binuclear palladium (II) complex and a preparation method and application thereof. Background technique [0002] With the rapid development of my country's social economy, industrialization, urbanization and aging are intensifying, population growth, lifestyle changes, and the incidence of cancer among residents is on the rise. At this time, the study of anticancer drugs and their mechanism of action on genetic material has very important theoretical value and practical significance. [0003] Cisplatin has been widely used in cancer chemotherapy since it was discovered in the 1970s that it can inhibit the growth of tumor cells, and it occupies a very important position in chemotherapy drugs. Cisplatin anticancer drugs have the characteristics of broad anticancer spectrum, strong effect, and synergistic effect with various anticancer drugs. First-line drugs, especi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
CPCA61P35/00C07B2200/13C07F15/0066
Inventor 谭明雄覃其品
Owner YULIN NORMAL UNIVERSITY
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