Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of 2-phenylpyridine dinuclear palladium (ii) complex and its preparation method and application

A technology of phenylpyridine and complexes, applied in the field of 2-phenylpyridine binuclear palladium complexes and its preparation, can solve the problems of side effects, macrocytic toxicity, and drug resistance in patients, and achieve good potential medicinal value , significant in vitro antitumor activity and cytotoxic selectivity

Active Publication Date: 2020-05-05
YULIN NORMAL UNIVERSITY
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cisplatin anticancer drugs have high cytotoxicity, and patients receiving treatment will have side effects, and drug resistance will gradually develop during treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of 2-phenylpyridine dinuclear palladium (ii) complex and its preparation method and application
  • A kind of 2-phenylpyridine dinuclear palladium (ii) complex and its preparation method and application
  • A kind of 2-phenylpyridine dinuclear palladium (ii) complex and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0029] (2) Heating and stirring the mixed solution, allowing it to fully react at 100° C. for 24 h, then cooling to room temperature, removing the solvent, and obtaining a small amount of reddish-brown liquid.

[0030] (3) Add 3.0mL of methanol and 2.0mL of chloroform to the reddish-brown liquid and let it stand for 34 days until the yellow crystals are completely precipitated to obtain the 2-phenylpyridine dinuclear palladium (II) complex with a yield of 98.3% .

[0031] (4) The yellow crystal separated out is subjected to infrared spectroscopy (see figure 1 ), X-ray single crystal diffraction (see figure 2 ) and elemental analysis (see Table 2) determination. Infrared spectrum IR (KBr): 1680cm ...

Embodiment 2

[0035] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0036] (2) Heating and stirring the mixed solution, allowing it to fully react at 60° C. for 70 h, then cooling to room temperature, and removing the solvent to obtain a small amount of reddish-brown liquid.

[0037] (3) Add 92mL of ethanol and 2mL of acetone into the reddish-brown liquid and let it stand for 34 days until the yellow crystals are completely precipitated to obtain the 2-phenylpyridine dinuclear palladium(II) complex with a yield of 85.0%.

[0038] (4) The precipitated yellow crystals were subjected to the same measurement as in Example 1, and the measurement results were the same as those in Example 1. It was determined that the yellow crystals were 2-phenylpyridine binuclear palladium ...

Embodiment 3

[0040] (1) Weigh 1.0mol palladium acetate and 1.0mol 2-phenylpyridine, place in a 100mL round bottom flask, add 5.0mL glacial acetic acid, that is, the mol ratio of palladium acetate, 2-phenylpyridine and glacial acetic acid is 1: 1:0.0875, mix well to obtain a mixed solution.

[0041] (2) Heating and stirring the mixed solution, allowing it to fully react at 135° C. for 10 h, cooling to room temperature, and removing the solvent to obtain a small amount of reddish-brown liquid.

[0042] (3) Add 50 mL of ethanol and 3 mL of dichloromethane into the reddish-brown liquid, and let it stand for 34 days until the yellow crystals are completely precipitated to obtain 2-phenylpyridine binuclear palladium (II) complex with a yield of 90.0%.

[0043] (4) The precipitated yellow crystals were subjected to the same measurement as in Example 1, and the measurement results were the same as those in Example 1. It was determined that the yellow crystals were 2-phenylpyridine binuclear pallad...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a 2-phenylpyridine binuclear palladium (II) complex, the structural formula of which is as follows. The invention also discloses a preparation method of the 2-phenylpyridine binuclear palladium (II) complex, Mix glacial acetic acid, palladium acetate and 2-phenylpyridine evenly, react completely under stirring and heating, cool to room temperature, remove glacial acetic acid to obtain a reddish-brown liquid, add a polar solvent, and stand until the yellow crystals are completely precipitated to obtain 2‑Phenylpyridine Binuclear Palladium(II) Complexes. The invention also discloses the application of the 2-phenylpyridine binuclear palladium (II) complex. The 2-phenylpyridine binuclear palladium (II) complex of the invention has obvious in vitro anti-tumor activity and cytotoxicity selectivity, and the preparation method is simple and easy for industrial production.

Description

technical field [0001] The invention relates to a binuclear metal complex, in particular to a 2-phenylpyridine binuclear palladium (II) complex and a preparation method and application thereof. Background technique [0002] With the rapid development of my country's social economy, industrialization, urbanization and aging are intensifying, population growth, lifestyle changes, and the incidence of cancer among residents is on the rise. At this time, the study of anticancer drugs and their mechanism of action on genetic material has very important theoretical value and practical significance. [0003] Cisplatin has been widely used in cancer chemotherapy since it was discovered in the 1970s that it can inhibit the growth of tumor cells, and it occupies a very important position in chemotherapy drugs. Cisplatin anticancer drugs have the characteristics of broad anticancer spectrum, strong effect, and synergistic effect with various anticancer drugs. First-line drugs, especi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61P35/00
CPCA61P35/00C07B2200/13C07F15/0066
Inventor 谭明雄覃其品
Owner YULIN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com