Unlock instant, AI-driven research and patent intelligence for your innovation.

Method and device for continuously splitting D-pantolactone

A technology of pantolactone and gyration, applied in the field of enzyme resolution, which can solve the problems of low resolution efficiency and achieve high resolution efficiency, cost reduction, and less destructive effects

Pending Publication Date: 2018-09-21
JIANGSU LINGYUN PHARMA
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, no matter which method is used, the current situation of splitting is batch production, that is, a relatively large container (usually using a trough) is used to prepare an aqueous solution of a certain concentration of DL-ester (swirling pantolactone). Put in a certain amount of split enzyme, stir for some time, adjust the pH value with ammonia water during the period, and filter the split hydrolyzate after reaching the optical rotation requirement, and the obtained mixed solution is composed of DL-ester, L-ester and D-acid; and then Stop the operation, output the hydrolyzate, re-inject new DL-ester, repeat the above operation, the resolution is inefficient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and device for continuously splitting D-pantolactone
  • Method and device for continuously splitting D-pantolactone
  • Method and device for continuously splitting D-pantolactone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A method for continuous resolution of vortex pantotolactone, adding resolution enzyme and vortex pantotolactone aqueous solution to the resolution column for resolution, after the resolution reaches equilibrium, continuous separation from the bottom of the resolution column Transport the vortexed pantolactone aqueous solution for continuous resolution, and the balanced solution flows out from the top of the separation column. The rate A of continuously transporting the vortexed pantotolactone aqueous solution meets the following conditions:

[0043]

[0044] In the formula: A is the speed, the unit is L / min, V is the volume of the split column, the unit is L; T is the setting split time used for the gyropantolactone of the split-splitting column volume to reach equilibrium , the unit is h; 60 means 60min / h.

[0045] The addition G of resolution enzyme satisfies the following conditions in the present embodiment:

[0046]

[0047] G is the addition amount of resol...

Embodiment 2

[0052] Such as figure 1 A device for the continuous separation of vortex substances is shown:

[0053]

[0054]

[0055] Described device comprises split column 1, raw material tank 2, lye storage tank 10, and described raw material tank 2 links to each other with the inlet 13 of split column 1 bottom by raw material delivery pump 3, and described lye storage tank 10 passes through The lye delivery pump 9 links to each other with the lye inlet 14 at the bottom of the splitting column 1; the pH probe 7 is mounted on the splitting column 1, and the top of the splitting column 1 is provided with a discharge port 15; the raw material delivery pump 3 has or A flow control valve is connected. The raw material flow rate A controlled by the flow control valve satisfies the following conditions

[0056]

[0057] In the formula: A is the speed, the unit is L / min, V is the volume of the split column, the unit is L; T is the setting split time used for the gyropantolactone of t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for continuously splitting D-pantolactone. A split enzyme and a D-pantolactone aqueous solution are added into a splitting column for splitting, after splitting reachesbalance, the D-pantolactone aqueous solution starts to be continuously conveyed from the bottom of the splitting column for continuous splitting, the balanced solution flows out from the top of the splitting column, and the speed A of the continuously conveyed D-pantolactone aqueous solution meets following conditions, wherein A refers to the speed with the unit of L / min, V refers to the splitting column volume with the unit of L, T refers to set splitting time for splitting one splitting column volume of D-pantolactone to reach balance, the unit of T is h, and 60 refers to 60 min / h. By meansof the method for continuously splitting D-pantolactone, continuous splitting D-pantolactone can be achieved, the efficiency is improved, and the cost of a field can be reduced, wherein A meets the condition shown in the description.

Description

technical field [0001] The invention relates to the technical field of enzymatic resolution, in particular to a method for continuous resolution of vortex pantolactone and a device thereof. Background technique [0002] Calcium D-pantothenate, as a member of the B vitamins, is widely used in the fields of feed additives, food additives and medicine, especially in animal feed additives, and the demand is increasing year by year. In recent years, the supply has been in short supply. , the price keeps rising. [0003] In the production of calcium D-pantothenate, D-pantothenic acid (chemical name: (+) 2,4-dihydroxy-3,3-dimethylbutyric acid) is a key intermediate. The chemical synthesis of D-pantothenic acid is mature, but the steps are cumbersome and the crystallization of the racemized product is expensive. The production of optically pure D-pantothenic acid by biological enzymatic method can further upgrade the synthesis process. The biological enzymatic method mainly includ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12P41/00C12P17/04C12M1/40C12M1/36C12M1/34C12M1/12C12M1/04C12M1/02
CPCC12M21/18C12M29/00C12M29/04C12M29/14C12M41/00C12M41/26C12P17/04C12P41/001
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA