Degradable antibacterial and hemostatic material based on porous structure carrier and preparation method thereof

Abstract

The invention discloses a degradable antibacterial and hemostatic material based on a porous structure carrier. The degradable antibacterial and hemostatic material is prepared from, by weight, 20-60parts of chitosan hydrochloride, 40-80 parts of sodium carboxymethylcellulose, 0.5-1.5 parts of calcium-contained organic compound and 0.1-0.5 part of antibacterial agents. Due to the porous structure, the adsorption superficial area is increased, and the adsorption effect is better compared with powdery or granular gel; the prepared porous structure has the advantages of being degradable and goodin biocompatibility. Due to the porous structure, the problem that chitosan or sodium carboxymethylcellulose is singly adopted is well solved, and the good liquid absorption and hemostatic synergistic effect is generated; meanwhile, antibacterial agents loaded on the porous structure can further enhance the antibacterial effect of the porous structure. The preparation method omits consumption ofa crosslinking agent, distilled water is adopted mostly, post-treatment is easier and more convenient, and meanwhile the product safety is improved.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a degradable antibacterial and hemostatic material based on a porous structure carrier and a preparation method thereof. Background technique [0002] Hemorrhage is the first cause of death in war injuries and the second cause of death in trauma. Hemorrhage is also the main cause of death in the operating room of trauma patients. Hemostasis is an important part of various operations, war injuries, and trauma first aid. The current Hemostatic materials and hemostatic drugs produce hemostatic effect by embolizing and constricting small arteries and capillaries; enhancing platelet function and accelerating blood coagulation process; or producing hemostatic effect by burning, compressing and suturing blood vessels. In the long-term production and living practice, people have found that materials with porous structure are often accompanied by good hemostatic function. For exam...

AI Technical Summary

Problems solved by technology

Porous materials such as porous fibers and porous sponges are used as hemostatic materials, but these materials cannot be degraded and will cause adverse effects on the human body

They mostly adopt emulsification cross-linking method in the preparation process, and the use of organic reagents is relatively complicated. For the later sample processing process, the process is complicated, which is easy to cause environmental pollution, and the overall cost is high and expensive.

The traditional hemostasis methods mostly use cotton and gauze as the bottom layer to contact the wound to absorb blood, and also use pressure to achieve the purpose of hemostasis, but the above materials can only absorb blood but cannot achieve rapid hemostasis function of

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