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Preparation method of nano hydrogel microsphere

A nano-hydrogel and microsphere technology, which is applied in the field of preparation of nano-hydrogel microspheres, can solve the problems of difficult purification of nano-hydrogel, large particle size, and difficulty in preparing size nano-hydrogel.

Inactive Publication Date: 2018-09-28
QIDONG CHUANGLYU GREENING ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The conventional precipitation polymerization method does not use small molecule additives such as emulsifiers, and the surface of the prepared nanogel is pollution-free, but the particle size is usually relatively large; more emulsifiers are used in the emulsion polymerization reaction formula, which gives the nanogel The purification of the gel brings great difficulties; the micro-template polymerization method is limited by the size of the template. This method is difficult to prepare smaller nano-hydrogels

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A method for preparing nano hydrogel microspheres, characterized in that it comprises the following steps: add 20 parts of MAA, 15 parts of DVB, 8 parts of AIBN and 90 parts of acetonitrile into a round bottom flask, ultrasonically disperse for 35 minutes, and heat up to 85°C for reaction 3h, put it into a distillation apparatus, distill out acetonitrile, then add anhydrous ethanol to wash 4 times, distill out ethanol, and dry at 60°C to obtain it; all raw materials are in parts by weight.

Embodiment 2

[0015] A method for preparing nano hydrogel microspheres, characterized in that it comprises the following steps: add 15 parts of MAA, 10 parts of DVB, 7 parts of AIBN and 85 parts of acetonitrile into a round bottom flask, ultrasonically disperse for 30 minutes, and heat up to 84°C for reaction After 2.5 hours, put it into a distillation apparatus, distill out acetonitrile, then add absolute ethanol to wash 4 times, distill out ethanol, and dry at 55°C to obtain it; all raw materials are in parts by weight.

Embodiment 3

[0017] A method for preparing nano hydrogel microspheres, characterized in that it comprises the following steps: add 25 parts of MAA, 20 parts of DVB, 9 parts of AIBN and 95 parts of acetonitrile into a round bottom flask, ultrasonically disperse for 40 minutes, and heat up to 86°C for reaction After 3.5 hours, put it into a distillation device, distill out acetonitrile, then add absolute ethanol to wash 4 times, distill out ethanol, and dry at 65°C to obtain the product; all raw materials are in parts by weight.

[0018] The method is simple, quick and easy to operate, and the prepared nanometer hydrogel microsphere methylene blue has strong adsorption and can be prepared on a large scale.

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PUM

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Abstract

The invention discloses a preparation method of a nano hydrogel microsphere. The preparation method comprises the following steps: adding methacrylic acid (MAA), divinyl benzene (DVB), azodiisobutyronitrile (AIBN) and acetonitrile in a round-bottom flask, carrying out ultrasonic dispersion for 30-40 minutes, carrying out heating to 84-86 DEG C, carrying out a reaction for 2.5-3.5 hours, putting the obtained substance in a distillation device, distilling off the acetonitrile, then adding absolute ethanol, carrying out washing for 4 times, distilling off the ethanol, and carrying out drying at 55-65 DEG C to obtain the nano hydrogel microsphere. The method is simple and rapid and is easy to operate, and the prepared nano hydrogel microsphere methylene blue has strong adsorption and can be prepared on a large scale.

Description

technical field [0001] The invention relates to a preparation method of nano hydrogel microspheres. Background technique [0002] Nano hydrogel microspheres refer to microsphere particles whose size is in the range of 1-1000nm and can be uniformly dispersed in water. As a new type of polymer nanomaterial, nanohydrogel has developed rapidly in recent years, and has achieved many breakthrough research results. This is because it has attractive prospects in the field of biomedicine, and can be used for targeted drug delivery and controlled release, gene transfection, medical diagnosis, biosensors, and separation and purification of biological substances. Based on the above uses, what is directly related is the particle size of the nano-hydrogel and its adsorption performance on material particles. Different preparation methods directly affect the size of nanoparticles. The methods for synthesizing nano-hydrogels include precipitation polymerization, inverse emulsion polymeriz...

Claims

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Application Information

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IPC IPC(8): C08F220/14C08F212/36B01J13/14C08J3/075C08L33/12
CPCC08F220/14B01J13/14C08J3/075C08J2333/12C08F212/36
Inventor 不公告发明人
Owner QIDONG CHUANGLYU GREENING ENG CO LTD