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Composite Collagen Hydrogel Material, Implantable Ophthalmic Devices Comprising the Material, and Methods of Making the Material and the Device

A collagen hydrogel, ophthalmic device technology, applied in skin transplantation, eye implants, medical science, etc., can solve the complex ability of corneal integrity, transparency, and release of non-toxic cells and therapeutic substances that affect optical clarity issues such as

Active Publication Date: 2021-12-03
LINKOCARE LIFE SCI AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These requirements may be reversed - release of cells or substances requires some degree of biodegradation, however, this may affect optical clarity and corneal integrity
In addition, requirements for transparency and non-toxicity of biomaterials can complicate the ability to encapsulate, deliver, and monitor release of cells and therapeutic substances in vivo

Method used

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  • Composite Collagen Hydrogel Material, Implantable Ophthalmic Devices Comprising the Material, and Methods of Making the Material and the Device
  • Composite Collagen Hydrogel Material, Implantable Ophthalmic Devices Comprising the Material, and Methods of Making the Material and the Device
  • Composite Collagen Hydrogel Material, Implantable Ophthalmic Devices Comprising the Material, and Methods of Making the Material and the Device

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Embodiment Construction

[0123] a) at figure 1 A schematic diagram of a device 1 is shown in , comprising a first region A with a composite collagen hydrogel material 2 and a second region B comprising only a cross-linked collagen network 3, the composite collagen hydrogel material 2 Contains a partially compressed three-dimensional collagen network 3 embedded in a cross-linked collagen network 4 .

[0124] b) Figure 2a The scanning electron microscope (SEM) micrograph in shows the SEM micrograph of the three-dimensional collagen network 3 before its incorporation into the cross-linked collagen network 4. Figure 2b shows the cross-linked collagen network 4 of region B of device 1, while Figure 2c A SEM micrograph of the composite collagen hydrogel material 2 in the first region A is shown. As can be seen from these micrographs, compared to the cross-linked collagen network 4 ( Figure 2b ), three-dimensional collagen network 3 ( Figure 2a ) exhibit a more compact fiber structure.

[0125] ...

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Abstract

Composite collagen-hydrogel materials for tissue engineering, and implantable ophthalmic devices incorporating such composites. The composite material comprises: a first collagen network comprising collagen crosslinked with a first crosslinking agent, and / or a second collagen network comprising collagen crosslinked with a second crosslinking agent, and a three-dimensional collagen network comprising Partially and plastically compressed collagen hydrogels with a degree of compression of 50-95%, wherein a three-dimensional collagen network is embedded in said first collagen network and / or second collagen network, and said first collagen network and / or The second collagen network and the three-dimensional collagen network are physically and chemically interconnected in the composite collagen hydrogel material.

Description

technical field [0001] The present disclosure relates to composite collagen hydrogel materials for tissue engineering and implantable ophthalmic devices incorporating such materials. The present disclosure also relates to methods of producing composite collagen hydrogel materials and implantable ophthalmic devices. Background technique [0002] Traditionally, injured and diseased tissues or organs have been treated or replaced with autografts, allografts, or synthetic or natural-based biomaterials. However, there is a huge global shortage of tissue grafts. Donor tissue grafts can also lead to donor site morbidity and loss of organ function, and allografts are associated with a risk of disease transmission and often require the use of immunosuppressant drugs. As for synthetic biomaterials, while many of them have achieved broad clinical applications, issues of seamless integration and immune response remain. These issues have led to a more recent paradigm shift to the deve...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/52
CPCA61L27/24A61L27/52A61L2430/16C08L89/04A61F2/0063A61F2/105A61F2/142A61F2/2478A61L27/3675A61L27/54A61L27/56A61L2300/412A61L2300/414A61L2300/64A61F2/1451
Inventor M·拉法特
Owner LINKOCARE LIFE SCI AB
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