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Preparation method of nano-magnetic resonance image reinforcing agent

An image enhancement and magnetic resonance technology, applied in the field of medical devices, can solve the problems of increasing the stability of nanoparticles, inability to mass-produce, and the size of liposomes being too large, achieving enhanced biocompatibility, highlighting nano-effects, Strong effect of the ability of the physiological tissue barrier

Pending Publication Date: 2018-10-16
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the commonly used liposome particle size is too large and the stability is small. Cholesterol is often used to increase the stability of nanoparticles or reduce the particle diameter. The existing liquid membrane method cannot be produced on a large scale.

Method used

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  • Preparation method of nano-magnetic resonance image reinforcing agent
  • Preparation method of nano-magnetic resonance image reinforcing agent
  • Preparation method of nano-magnetic resonance image reinforcing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Nano magnetic resonance image intensifier of the present invention, its preparation method comprises the following steps:

[0045] (1) Mix serum albumin and pure water at a mass ratio of 2.7:100, vortex and shake for 1 min at a rotational speed of 600 rpm, dissolve serum albumin in pure water, and obtain solution A;

[0046] (2) Mix lecithin and cyclohexane at a solid-to-liquid ratio of 1.5:100, vortex and shake for 1 min, and the vortex rotation speed is 600 rpm, so that lecithin is dissolved in cyclohexane to obtain solution B;

[0047] (3) Add the water-based ferroferrofluid into pure water, vortex and shake for 1min, and the vortex rotation speed is 600rpm, so that the water-based ferroferrofluid is dissolved in pure water to obtain solution C; the solution The concentration of iron ions in C is 1mg / ml;

[0048] (4) Add solution A of step (1) to solution B of step (2), vortex for 3 minutes at a rotational speed of 600 rpm, and then perform ultrasonic treatment for ...

Embodiment 2

[0054] Nano magnetic resonance image intensifier of the present invention, its preparation method comprises the following steps:

[0055] (1) Mix soybean protein and pure water at a mass ratio of 3:100, vortex and shake for 3 minutes, and the rotation speed of the vortex is 1140rpm, so that soybean protein is dissolved in pure water to obtain solution A;

[0056] (2) Mix cephalin and chloroform at a solid-to-liquid ratio of 1.8:100, vortex and shake for 4 minutes, and the vortex rotation speed is 1680rpm to obtain solution B;

[0057] (3) Add gadolinium trichloride hexahydrate into pure water, vortex and shake for 4min, and the rotational speed of the vortex is 1700rpm to obtain solution C; the concentration of trivalent gadolinium ions in the solution C is 100mg / ml;

[0058] (4) Add solution A of step (1) to solution B of step (2), vortex for 5 minutes at a speed of 1140 rpm, and then perform ultrasonic treatment for 15 minutes at an ultrasonic frequency of 20 Hz and an ultra...

Embodiment 3

[0064] Nano magnetic resonance image intensifier of the present invention, its preparation method comprises the following steps:

[0065] (1) Mix the water-soluble ganoderma protein and pure water at a mass ratio of 3.3:100, vortex and shake for 4 minutes, and the vortex rotation speed is 1680rpm, so that the water-soluble ganoderma protein is dissolved in pure water to obtain solution A;

[0066] (2) Mix cardiolipin and benzene at a solid-to-liquid ratio of 2.1:100, vortex and shake for 7 minutes, and the vortex rotation speed is 2760rpm, so that cardiolipin is dissolved in benzene to obtain solution B;

[0067] (3) Add manganese acetate tetrahydrate and dysprosium trichloride into pure water, vortex and shake for 9min, and the rotational speed of the vortex is 2750rpm to obtain solution C; The concentration is 7mg / ml;

[0068] (4) Add the solution A of step (1) into the solution B of step (2), vortex and shake for 6 minutes, the vortex rotation speed is 2200rpm, and then pe...

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Abstract

The invention discloses a preparation method of a nano-magnetic resonance image reinforcing agent. The preparation method of the nano-magnetic resonance image reinforcing agent comprises the followingsteps: mixing a solution A containing soluble proteins with a solution B containing phospholipids to obtain a lipoprotein solution, reacting the lipoprotein solution and a solution C containing soluble metal salt and / or soluble metal chelate, and then evaporating a solvent in a reaction product of the reaction by using a rotary evaporator to obtain a gel; dissolving the gel in pure water to obtain a nano-emulsion, freeze-drying the nano-emulsion to obtain fluffy powder and then obtaining the nano-magnetic resonance image reinforcing agent; the preparation method of the nano-magnetic resonanceimage reinforcing agent changes the preparation process of nano-liposomes by the exiting reverse-phase evaporation method, and takes the phospholipids and water-soluble proteins as main raw materials, and uses paramagnetic metal ions as a chelating agent and a liposome stabilizer, and a cholesterol-free bio-simulation self-assembly method to prepare the nano-magnetic resonance image reinforcing agent, thereby being good in biocompatibility, avoiding toxic and side effects of external cholesterol on patients, and having good application prospects.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a preparation method of a nanometer magnetic resonance imaging enhancer. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging.MRI) is a high-tech imaging technology based on the resonance characteristics of biological magnetic nuclei (hydrogen nuclei) in static magnetic fields. This technology realizes non-destructive and rapid detection of biological internal organs and soft tissues. Now it has developed into a very important conventional means of medical diagnosis, especially for the diagnosis of soft tissue lesions and tumors. In order to enhance the contrast and clarity between images of diseased and normal tissue, appropriate image enhancement agents need to be selected to display anatomical features. Most of these image intensifiers use the paramagnetic properties of metal ions to reduce the relaxation time of adjacent water protons ...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/14A61K49/10
CPCA61K49/10A61K49/14A61K49/18
Inventor 聂国朝吴艳华
Owner YULIN NORMAL UNIVERSITY
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