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Anti-inflammatory triterpenoid saponin type compound as well as extraction method and application thereof

A technology of triterpenoid saponins and extraction method, which is applied in the field of anti-inflammatory triterpenoid saponins and its extraction, can solve the problem of chemical structure and anti-inflammatory activity. etc. to achieve good in vitro anti-inflammatory activity, controllable quality, and clear structure

Active Publication Date: 2018-10-16
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main active components in Quercus brevifolia acorns are triterpenoid saponins, but the existing researches on the chemical constituents of Quercus brevicina acorns are still not thorough enough. Composition still worthy of further research and development
[0006] The present invention systematically separates the triterpenoid saponins from Quercus brevifolia, and obtains a new class of triterpenoid saponins, whose chemical structure and anti-inflammatory activity have not been reported

Method used

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  • Anti-inflammatory triterpenoid saponin type compound as well as extraction method and application thereof
  • Anti-inflammatory triterpenoid saponin type compound as well as extraction method and application thereof
  • Anti-inflammatory triterpenoid saponin type compound as well as extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 Extraction of triterpene saponins

[0088] (1) Take 34.5 kg of dry Quercus brevifolia acorns, divide them into two equal batches of extraction, and extract each batch with 60 liters of 70% ethanol at 60°C for four times under reflux, combine all extracts and concentrate under reduced pressure to extract The volume is 30L;

[0089] (2) extracting solution in step 1) is extracted with cyclohexane, ethyl acetate and n-butanol successively of equal volume, obtains 595.29g n-butanol layer;

[0090] (3) Carry out macroporous resin column chromatography with n-butanol layer (500.6g), utilize aqueous methanol gradient elution (H 2 O, 10% aqueous methanol solution, 30% aqueous methanol solution, 50% aqueous methanol solution, 70% aqueous methanol solution, pure methanol; v / v), to obtain 70% methanol aqueous solution eluent (Y) and 100% methanol solution eluent ( Z) valid part;

[0091] (4) Y was subjected to silica gel column chromatography, eluted with chloroform-m...

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Abstract

The invention discloses an anti-inflammatory triterpenoid saponin type compound as well as an extraction method and application thereof. The compound is a novel triterpenoid saponin type compound andis identified through physical and chemical constants and modern spectroscopy to define physical and chemical properties and a chemical structure of the compound; powerful reference materials are provided for further researching and developing and utilizing the value of triterpenoid type chemical components in quercus glandulifera acorn kernels; a separation and purification method provided by theinvention is simple, efficient and moderate; meanwhile, a pharmacodynamics test proves that three novel triterpenoid saponin type compounds provided by the invention have a relatively good in-vitro anti-inflammatory effect and has anti-inflammatory activity on BV-2 cells; the compounds and tautomers and pharmaceutically acceptable salts thereof have a great potential of being prepared into a novel anti-inflammatory or Alzheimer's disease treatment medicine, and a foundation is laid for further developing the anti-inflammatory or Alzheimer's disease treatment medicine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an anti-inflammatory triterpene saponin compound and its extraction method and application. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to injury factors. Most diseases are accompanied by inflammation. Inflammation will aggravate the occurrence and development of diseases. Some chronic inflammations can lead to tumors. Therefore, the protection against inflammation Control and treatment are of great significance. [0003] Natural medicines, especially those derived from plants, have a variety of chemical structures and biological activities, and have always been the main source of human disease prevention and treatment. Many drugs used clinically are directly or indirectly derived from natural products. Natural products can not only be used as precursors for semi-synthetic drugs, but also as templates for chemically synthesized...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07J73/00A61K31/7024A61P29/00A61P25/28A61P1/16A61P11/00A61P25/00A61P1/00A61P9/00
CPCA61P1/00A61P1/16A61P9/00A61P11/00A61P25/00A61P25/28A61P29/00C07J63/008C07J73/008A61P15/14
Inventor 何祥久王宜海雷艳琼黄雨颖
Owner GUANGDONG PHARMA UNIV
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