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Uses of chlorogenic acid in preparation of injections with skin whitening effect

A technology of skin whitening and injection, which is applied in the field of medicine and can solve problems such as increasing melanin content

Inactive Publication Date: 2018-10-23
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But they have their own shortcomings: kojic acid has the potential risk of causing cancer; the effect of arbutin on melanin content is bidirectional, that is, it can inhibit the synthesis of melanin at a certain concentration, while it can increase it in another concentration range. melanin content

Method used

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  • Uses of chlorogenic acid in preparation of injections with skin whitening effect
  • Uses of chlorogenic acid in preparation of injections with skin whitening effect
  • Uses of chlorogenic acid in preparation of injections with skin whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Example 1 Chlorogenic Acid Freeze-dried Powder for Injection

[0024] In this example, chlorogenic acid freeze-dried powder for injection was prepared according to the method of Example 1 in patent ZL201310366945.0.

[0025] 1. Main drug

[0026] Chlorogenic acid, extracted from Eucommia ulmoides leaves by Sichuan Jiuzhang Biotechnology Co., Ltd., has a purity of 98.4%.

[0027] 2. Prescription:

[0028]

[0029] According to the above prescription, 1000 chlorogenic acid freeze-dried powders for injection were prepared by freeze-drying with a specification of 30 mg / bottle.

[0030] In the following experimental examples, the chlorogenic acid freeze-dried powder injections were all prepared according to Example 1.

[0031] The beneficial effects of the present invention are demonstrated through experimental examples below.

experiment example 1

[0032] Experimental Example 1 Clinical trial of chlorogenic acid for injection to improve facial skin pigmentation and skin whitening effect

[0033] There is currently a phase I clinical trial of chlorogenic acid for injection in the treatment of malignant glioma (clinical approval number: 2013L01855) carried out in Beijing Shijitan Hospital Affiliated to Capital Medical University. The administration dose of the group is respectively intramuscular injection of chlorogenic acid freeze-dried powder injection (prepared according to Example 1) every morning, and continuous injection for 4 weeks.

[0034] As an exploratory index of clinical trials, after using chlorogenic acid for injection, all subjects were ① using computer local skin photography to observe the change of skin color; ② testing their skin pigment in MDD-MX18 skin melanin tester, There are 12 subjects in total.

[0035] Among them, computer partial photos were used to compare the changes in skin color. The curat...

experiment example 2

[0042] Experimental Example 2 Animal Research of Inhibiting Pigment Synthesis with Chlorogenic Acid for Injection

[0043] 1. Experimental drugs and animals

[0044] Chlorogenic acid freeze-dried powder for injection was provided by Sichuan Jiuzhang Biotechnology Co., Ltd.; pure chlorogenic acid with a purity of 99.5% was provided by Sichuan Jiuzhang Biotechnology Co., Ltd.; Balb / c mice were purchased from Sichuan Provincial People’s Hospital.

[0045] 2. Grouping of experimental animals and experimental methods

[0046] The experimental mice that passed the quarantine were randomly divided into 4 groups, 10 in each group: ① Group 1 was the blank control group; ② Group 2 was the intramuscular administration group of chlorogenic acid for injection; ③ Group 3 was the intravenous administration of chlorogenic acid for injection group; ④ Group 4 was oral administration of pure chlorogenic acid;

[0047] Among them, the mice in the blank control group were kept without any treat...

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Abstract

The present invention discloses uses of chlorogenic acid in preparation of injections with skin whitening effect. According to the present invention, the pharmacodynamic experiment results show that chlorogenic acid can significantly inhibit the synthesis of melanin, and has the effect significantly superior to the existing drug arbutin, and the effect of the chlorogenic acid injection is better than the effect of the oral preparation; and the clinical trial results show that the average effective rate in the treatment of pigmentation is 100% and the skin color L values of each group of subjects are decreased significantly after the subjects are administered with the chlorogenic acid for injection, such that the results indicate that chlorogenic acid has significant skin whitening effect.

Description

technical field [0001] The invention relates to the use of chlorogenic acid in preparing an injection with skin whitening effect, and belongs to the field of medicine. Background technique [0002] Melanin is a biological pigment synthesized by animal melanocytes, which can absorb ultraviolet rays to protect the skin from ultraviolet rays. However, in the modern society with rapid economic development, the pollution is getting more and more serious, resulting in the formation and expansion of the ozone hole, which makes the human skin absorb more and more ultraviolet rays; coupled with the increase in the pressure of modern urban life, Irregular work and rest time, such as staying up late and using low-quality cosmetics, etc., these factors will cause the melanocytes to synthesize melanin and cause various pigmentation disorders, such as sunburn, chloasma and so on. Pigmentation disorders not only seriously affect the appearance of the face, but also bring certain mental st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K47/26A61P17/00
CPCA61K31/216A61K9/0019A61K47/26
Inventor 张洁陈晓光李文斌张梦甜
Owner SICHUAN JIUZHANG BIO TECH CO LTD