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Application of gerbera officinalis extract and preparation method of effective components thereof

A technology of Gerbera gerbera and its extract is applied in the field of application of Gerbera gerbera extract for inhibiting alpha-glucosidase and preparation of effective components thereof

Active Publication Date: 2021-06-18
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports in the literature on the inhibitory effect of gerbera officinalis extracts and compounds on α-glucosidase

Method used

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  • Application of gerbera officinalis extract and preparation method of effective components thereof
  • Application of gerbera officinalis extract and preparation method of effective components thereof
  • Application of gerbera officinalis extract and preparation method of effective components thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] (1) Preparation of components

[0029] Get 180 g of Herbs sativa (through a 100-mesh sieve), ultrasonically extract with 5 times the amount of methanol solution (900ml) for 1 hour, filter, and then use 3 times the amount of methanol solution (540ml) for ultrasonic extraction of the filter residue twice, each time for 1 hour, Filtrate, combine the filtrates for 3 times and concentrate to 8.9g of extract (total extract of Herba chrysalis), add 3 times the amount of water (27ml) to mix and dissolve, first extract with 2 times the volume of petroleum ether, add acid to the water layer Adjust the pH value to 5, then extract with 2 times the volume of ethyl acetate, continue to extract the water layer with 2 times the amount of n-butanol, and concentrate the extracts respectively to obtain 2.6g of petroleum ether and 3.2g of ethyl acetate , n-butanol fraction 1.7g. The specific indicator process is as follows: figure 2 mentioned.

[0030] (2) Screening of active component...

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Abstract

The invention discloses the application of gerbera officinalis extract and the preparation method of its effective components. The invention finds that the ethyl acetate part and the petroleum ether part have a certain inhibitory effect on the activity of α-glucosidase, and the ethyl acetate part inhibits the activity of α-glucosidase The strongest, followed by the petroleum ether part, thus proposing the application of the gerbera officinalis extract in the treatment of diabetes drugs. This has laid a certain foundation for the research of natural herbal medicine gerbera in inhibiting α-glucosidase.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicine extracts, in particular to the application of gerbera officinalis extract to inhibit α-glucosidase and the preparation method of its effective components. [0002] technical background [0003] Diabetes is a disease characterized by high blood sugar, absolute or relative deficiency of insulin in human blood, and a series of metabolic disorders such as fat and protein. At present, the number of diabetics in China is the country with the largest absolute number of patients in the world. At present, the drugs for clinical treatment of diabetes mainly include: (1) promoting insulin secretion, such as glibenclamide, repaglinide, etc.; (2) reducing liver sugar production, such as metformin; (3) enhancing the effect of insulin, Such as rosiglitazone, ciglitazone, etc.; (4) delaying the digestion and absorption of carbohydrates, such as α-glucosidase inhibitors-acarbose...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P3/10
CPCA61K36/28A61K2236/333A61K2236/51A61K2236/55A61P3/10
Inventor 马雪汪洋刘春花王广成李勇军潘洁孙佳郑林刘亭
Owner GUIZHOU MEDICAL UNIV