Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of high-purity stigmasterol monomer

A stigmasterol, high-purity technology, applied in steroids, organic chemistry, etc., can solve the problems of low stigmasterol yield, large solvent consumption, and many crystallization times, and achieve separation efficiency, high yield, and product yield. High, easy-to-use effects

Inactive Publication Date: 2018-10-26
武汉藤欣生物工程有限公司
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solvent crystallization method has the disadvantages of large amount of solvent used, low recovery rate, and many crystallization times, and the yield of stigmasterol is low, and the purification cost is high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment includes the following steps:

[0029] (1) Get mixed phytosterol 200.0g (total sterol content 89.0%, stigmasterol relative content 28.4%, Yichun Big Turtle Life Science Co., Ltd.), put into melting crystallizer, use high-purity nitrogen (high-purity nitrogen ≥ 99.5%) , the same below) to replace the air in the melting crystallizer, and raise the temperature in the melting crystallizer to 170° C. to completely melt the raw material mixed phytosterols;

[0030] (2) Slowly lower the temperature of the melting crystallizer at a rate of 2°C / h, stop cooling when the temperature in the melting crystallizer drops to 145°C, and after standing for crystallization for 4 hours, collect by-product phytosterol A through the filter plate at the bottom of the melting crystallizer ;

[0031] (3) Slowly heat up the melting crystallizer at a rate of 2 °C / h, and the temperature rises to 160 °C to make it sweat, and collect by-product phytosterol B through the filter plate ...

Embodiment 2

[0036] This embodiment includes the following steps:

[0037] (1) Get mixed phytosterol 200.0g (phytosterol content 85.0%, stigmasterol relative content 23.5%, COFCO Tianke Biological Engineering Co., Ltd.), put into melting crystallizer, use high-purity nitrogen (nitrogen ≥ 99.5%, lower Same) replace the air in the melting crystallizer, raise the temperature in the melting crystallizer to 170°C to melt all the raw material mixed phytosterols;

[0038] (2) Slowly lower the temperature of the melting crystallizer at a rate of 2°C / h, stop the cooling when the temperature in the melting crystallizer drops to 142°C, and after standing for crystallization for 3 hours, collect by-product phytosterol A through the filter plate at the bottom of the melting crystallizer ;

[0039] (3) Slowly heat up the melting crystallizer at a rate of 2 °C / h, and the temperature rises to 158 °C to make it sweat, and collect by-product phytosterol B through the filter plate at the bottom of the melti...

Embodiment 3

[0044] This embodiment includes the following steps:

[0045] (1) Get mixed phytosterol 200.0g (phytosterol content 96.7%, stigmasterol relative content 32.8%, Fengyi Spring Valley Biotechnology (Jiangsu) Co., Ltd.), put into melting crystallizer, use high-purity nitrogen (nitrogen ≥ 99.5%, the same below) replaces the air in the melting crystallizer, and the temperature in the melting crystallizer is raised to 170° C. to completely melt the raw material mixed phytosterols;

[0046] (2) Slowly lower the temperature of the melting crystallizer at a rate of 2°C / h, stop cooling when the temperature in the melting crystallizer drops to 144°C, and after standing for crystallization for 2 hours, collect by-product phytosterol A through the filter plate at the bottom of the melting crystallizer ;

[0047] (3) Slowly heat up the melting crystallizer at a rate of 3 °C / h, and the temperature rises to 158 °C to make it sweat, and collect by-product phytosterol B through the filter plate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a high-purity stigmasterol monomer. A manner of coupling melt crystallization and solvent crystallization is adopted, the characteristics of larger melting difference existing between stigmasterol and beta-sitosterol (the melting point of the stigmasterol is 165-167 DEG C, and the melting point of the beta-sitosterol is 136-140 DEG C) and the difference of the dissolving degrees of the stigmasterol and the beta-sitosterol along with the variation of the temperature are utilized to achieve efficient separation to obtain the high-purity stigmasterolmonomer, and the application in the fields of medicine, food, cosmetics and the like are met. The method has the advantages that the operation is simple, the separation efficiency and the yield are higher, mixed plant sterol with the purity of 85% or above on sale on markets is taken as the raw material, the high-purity stigmasterol monomer can be obtained by conducting melt crystallization, sweating and solvent crystallization for one time, and the total yield of products reaches 60% or above.

Description

technical field [0001] The invention relates to a preparation method of high-purity stigmasterol monomer. Background technique [0002] Phytosterol is a natural active substance that exists in plants. It is widely distributed in nature. It is one of the components that form the cell membrane in plants and is also the synthetic precursor of various hormones, vitamin D and steroids. The phytosterols crystallized and separated from vegetable oil refining deodorizer distillate (Deodorizer Distillate oil, referred to as DD oil) are a mixture of nearly 20 kinds of sterols, mainly including four kinds of brassicasterol, campesterol, stigmasterol and β-sitosterol. [0003] As a synthetic sex hormone, adrenocortical hormone (prednisone anti-inflammatory rheumatic drugs), steroidal contraceptives, menopausal disease treatment drugs, diuretics, antineoplastic drugs, assimilation hormones and fat-inducing hormones and other drugs parent compound, The manufacture of steroid hormones and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
CPCC07J9/00
Inventor 魏国华周小波
Owner 武汉藤欣生物工程有限公司