Application of compound in treating or preventing altitude sickness

A compound and altitude sickness technology, applied in the field of biomedicine, can solve problems that have not yet been seen in the application of Vericiguat

Active Publication Date: 2018-11-02
GENERAL HOSPITAL OF PLA
View PDF14 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of Veric

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 contains the compound ( Image 6 ) preparation of the pharmaceutical composition

[0075] 1. Formula (calculated by weight percentage)

[0076] {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}amino Methyl formate 10%, sucralose 2%, microcrystalline cellulose 40%, polyvinylpyrrolidone 35%, glycerin 10%, calcium hydrogenated stearate 3%.

[0077] 2. Preparation method

[0078] Weigh each component according to the formula, mix and stir them evenly, and compress into tablets with 200 mg each.

Embodiment 2

[0079] Therapeutic effect of embodiment 2 Vericiguat on altitude sickness

[0080] 1. Materials and methods:

[0081] 1.1 Animals

[0082] 40 SD rats, male, weighing 180-220 g, clean grade, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2016-0006. Raising in a hypobaric oxygen chamber, regular feeding with full-price nutritional feed, room temperature 22-25°C, humidity 50%-70%.

[0083] 1.2 Reagents and samples

[0084] Vericiguat powder was synthesized by Wuhan WuXi AppTec New Drug Development Co., Ltd.;

[0085] Dimethyl sulfoxide (DMSO) was purchased from selleck;

[0086] Polyethylene glycol 200 was purchased from Sinopharm Material Reagent Co., Ltd.

[0087] The configuration method of Vericiguat: 10% DMSO dissolved drug + 50% polyethylene glycol 200 + 40% double distilled water. 1.3 Instruments

[0088] Hypobaric oxygen chamber (Guizhou Fenglei Aviation Ordnance Co., Ltd.); small animal ventilator...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides application of a compound having a general formula I or a pharmaceutically-acceptable salt thereof in preparing a drug composition for treating altitude sickness. The altitude sickness is selected from acute altitude sickness or chronic acute altitude sickness occurring in an altitude environment with the elevation being 2000m or more.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the use of a compound conforming to general formula I or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical composition for treating or preventing altitude sickness. Background technique [0002] Altitude sickness, or altitude sickness, is a natural physiological response that occurs when a person reaches a certain altitude and the body adapts to changes in air pressure, low oxygen content, and dry air caused by altitude. The symptoms of altitude sickness are generally manifested as headache, palpitation, fatigue, chest tightness, shortness of breath, vomiting, loss of appetite, convulsions, trance, and sudden decline in cognitive ability. Signs include rapid heart rate, deep breathing, mildly abnormal blood pressure, edema of the face or limbs, and cyanosis of the lips. At present, most of the prevention and treatment of altitude sickness are Rh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/506A61P39/00A61P9/02A61P9/00A61P9/12A61P11/00A61P7/10
CPCA61K31/506A61P7/10A61P9/00A61P9/02A61P9/12A61P11/00A61P39/00
Inventor 何昆仑刘春蕾李鑫李晨张泽宇高晓健
Owner GENERAL HOSPITAL OF PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap