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Application of compound in treating or preventing altitude sickness

A compound and altitude sickness technology, applied in the field of biomedicine, can solve problems that have not yet been seen in the application of Vericiguat

Active Publication Date: 2018-11-02
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of Vericiguat being applied to plateau environments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 contains the compound ( Image 6 ) preparation of the pharmaceutical composition

[0075] 1. Formula (calculated by weight percentage)

[0076] {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}amino Methyl formate 10%, sucralose 2%, microcrystalline cellulose 40%, polyvinylpyrrolidone 35%, glycerin 10%, calcium hydrogenated stearate 3%.

[0077] 2. Preparation method

[0078] Weigh each component according to the formula, mix and stir them evenly, and compress into tablets with 200 mg each.

Embodiment 2

[0079] Therapeutic effect of embodiment 2 Vericiguat on altitude sickness

[0080] 1. Materials and methods:

[0081] 1.1 Animals

[0082] 40 SD rats, male, weighing 180-220 g, clean grade, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2016-0006. Raising in a hypobaric oxygen chamber, regular feeding with full-price nutritional feed, room temperature 22-25°C, humidity 50%-70%.

[0083] 1.2 Reagents and samples

[0084] Vericiguat powder was synthesized by Wuhan WuXi AppTec New Drug Development Co., Ltd.;

[0085] Dimethyl sulfoxide (DMSO) was purchased from selleck;

[0086] Polyethylene glycol 200 was purchased from Sinopharm Material Reagent Co., Ltd.

[0087] The configuration method of Vericiguat: 10% DMSO dissolved drug + 50% polyethylene glycol 200 + 40% double distilled water. 1.3 Instruments

[0088] Hypobaric oxygen chamber (Guizhou Fenglei Aviation Ordnance Co., Ltd.); small animal ventilator...

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PUM

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Abstract

The invention provides application of a compound having a general formula I or a pharmaceutically-acceptable salt thereof in preparing a drug composition for treating altitude sickness. The altitude sickness is selected from acute altitude sickness or chronic acute altitude sickness occurring in an altitude environment with the elevation being 2000m or more.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the use of a compound conforming to general formula I or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical composition for treating or preventing altitude sickness. Background technique [0002] Altitude sickness, or altitude sickness, is a natural physiological response that occurs when a person reaches a certain altitude and the body adapts to changes in air pressure, low oxygen content, and dry air caused by altitude. The symptoms of altitude sickness are generally manifested as headache, palpitation, fatigue, chest tightness, shortness of breath, vomiting, loss of appetite, convulsions, trance, and sudden decline in cognitive ability. Signs include rapid heart rate, deep breathing, mildly abnormal blood pressure, edema of the face or limbs, and cyanosis of the lips. At present, most of the prevention and treatment of altitude sickness are Rh...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61P39/00A61P9/02A61P9/00A61P9/12A61P11/00A61P7/10
CPCA61K31/506A61P7/10A61P9/00A61P9/02A61P9/12A61P11/00A61P39/00
Inventor 何昆仑刘春蕾李鑫李晨张泽宇高晓健
Owner GENERAL HOSPITAL OF PLA
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