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Chitosan chlorogenic acid salt, preparation method and application thereof

A technology of chlorogenic acid salt and chitosan, which is applied in the field of daily chemicals, can solve problems such as failure to meet market requirements, application limitations, and weak biological activity, and achieve the effects of easy promotion, low cost, and improved biological activity

Active Publication Date: 2018-11-02
山东益诺康药业有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chitosan itself has weak biological activity and cannot meet market requirements, and its application is greatly limited.

Method used

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  • Chitosan chlorogenic acid salt, preparation method and application thereof
  • Chitosan chlorogenic acid salt, preparation method and application thereof
  • Chitosan chlorogenic acid salt, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The target compound chitosan chlorogenic acid was synthesized according to the above synthetic route.

[0029] Weigh 1.77 g of chlorogenic acid (see figure 1 ) in 50 mL of deionized water, heated at 60°C for 10 min to dissolve, and then added 0.80 g of chitosan (see figure 2 ), continue to stir and react at 60°C for 12 h, then precipitate with 200 mL of acetone, wash with absolute ethanol and acetone, and freeze-dry to obtain the chitosan chlorogenic acid salt shown in formula (1) (see image 3 ); wherein, the average degree of aggregation n ranges from 10 to 3000.

Embodiment 2

[0031] The difference from Example 1 is:

[0032] Weigh 3.54 g of chlorogenic acid in 50 mL of deionized water, heat at 70 °C for 10 min to dissolve, then add 0.80 g of chitosan, continue to stir and react at 70 °C for 10 h, then precipitate with 200 mL of acetone, and then separate After washing with absolute ethanol and acetone, and freeze-drying, the chitosan chlorogenic acid salt shown in formula (1) is obtained (see image 3 ); wherein, the average degree of aggregation n ranges from 10 to 3000.

Embodiment 3

[0034] The difference from Example 1 is:

[0035] Weigh 1.77 g of chlorogenic acid in 50 mL of deionized water, heat at 70 °C for 10 min to dissolve, then add 0.80 g of chitosan, continue to stir and react at 70 °C for 10 h, then precipitate with 200 mL of acetone, and then separate After washing with absolute ethanol and acetone, and freeze-drying, the chitosan chlorogenic acid salt shown in formula (1) is obtained (see image 3 ); wherein, the average degree of aggregation n ranges from 10 to 3000.

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Abstract

Relating to the daily chemical field and the pharmaceutical industry, the invention in particular provides a chitosan chlorogenic acid salt, a preparation method and application thereof. The chitosanchlorogenic acid salt has a structural formula shown as the specification, wherein the average degree of polymerization n is 10-3000. The preparation method includes: dissolving chlorogenic acid at high temperature, then carrying out salt forming reaction with chitosan directly to obtain the chitosan chlorogenic acid salt. And the molar quantity of chlorogenic acid is 1-2 times that of chitosan. The biological activity like antioxidant activity of the chitosan chlorogenic acid salt is greatly improved, the preparation raw materials are easily available, the preparation method is simple, the conditions are mild, and the chitosan chlorogenic acid salt can be developed into an antioxidant and widely applied in biology, medicine, food, chemical industry and other fields.

Description

technical field [0001] The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to a chitosan chlorogenic acid salt and a preparation method and application thereof. Background technique [0002] Chitin is a biological polysaccharide that exists in the shells of shrimps, crabs, insects, and fungal cell walls. It is the second most abundant polysaccharide resource in nature after cellulose. Chitosan is the only cationic polysaccharide obtained by deacetylation of chitin. Chitosan is a safe, non-toxic, biocompatible, and biodegradable polysaccharide, which has many unique physiological and pharmacological functional properties, and is widely used in various industries such as medicine, food, agriculture, daily chemicals, and environmental protection. in the field. Due to the existence of amino groups, chitosan has certain antibacterial and antioxidative activities, and can be used as the object of modification in order to develop s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K31/722A61P39/06
CPCA61K31/722A61P39/06C08B37/003
Inventor 郭占勇秦荣基谭文强秦荣珍董方姜峰
Owner 山东益诺康药业有限公司
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