Method and device for preparing nanoscale dispersion liquid

A dispersion liquid and nano-scale technology, applied in the direction of mixing methods, chemical instruments and methods, transportation and packaging, etc., can solve the problems of limited preparation volume, discontinuous preparation process, and increase in particle size of nanoparticles, so as to avoid excessive dilution, Achieving mass preparation and improving the effect of particle size

Active Publication Date: 2018-11-06
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The secondary growth of nanoparticles may increase the particle size, broaden the distribution and decrease the stability of nanoparticles
At the same time, the secondary mixing is stirring and mixing, which leads to the discontinuity of the whole preparation process, it is difficult to ensure the consistency between batches of products, and the amount of each preparation is limited

Method used

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  • Method and device for preparing nanoscale dispersion liquid
  • Method and device for preparing nanoscale dispersion liquid
  • Method and device for preparing nanoscale dispersion liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as figure 1 As shown, the nano-dispersion preparation device is equipped with a CIJ-L mixer with three inlets. The parts and operations in the device are represented by English letter codes, and the same parts are distinguished by numerical subscripts:

[0050] f O1 : organic phase solution,

[0051] f W0 , F W1 : aqueous solution,

[0052] C O1 :Organic solvents,

[0053] C W0 、C W1 :water,

[0054] V FO1 : organic phase storage tank,

[0055] V FW0 : circulating storage tank,

[0056] V FW1 : aqueous phase storage tank,

[0057] V CO1 : Organic solvent cleaning storage tank,

[0058] V CW0 , V CW1 : water cleaning storage tank,

[0059] V W : waste liquid storage tank,

[0060] SR 1 、SR 2 、SR 3 、SR 4 、SR F0 、SR W0 :Filter,

[0061] TV 0 、TV 1 、TV 2 、TV 3 :Three-way valve,

[0062] FV 0 、FV 1 、FV 2 :Four-way valve,

[0063] CHV 0 、CHV 1 、CHV 2 : check valve,

[0064] SV 0 :Shut-off valve,

[0065] P 0 ,P 1 ,P 2 :Pump, ...

Embodiment 2

[0080] Such as Figure 4 As shown, the nano-dispersion preparation device is equipped with a five-inlet CMIJ-L mixer. The parts and operations in the device are represented by English letter codes, and the same parts are distinguished by numerical subscripts:

[0081] f O1 , F O2 : organic phase solution,

[0082] f W0 , F W1 , F W2 : aqueous solution,

[0083] C O1 、C O2 :Organic solvents,

[0084] C W0 、C W1 、C W2 :water,

[0085] V FO1 , V FO2 : organic phase storage tank,

[0086] V FW0 : circulating storage tank,

[0087] V FW1 , V FW2 : aqueous phase storage tank,

[0088] V CO1 , V CO2 : Organic solvent cleaning storage tank,

[0089] V CW0 , V CW1 , V CW2 :: water cleaning tank,

[0090] V W : waste liquid storage tank,

[0091] SR 1 、SR 2 、SR 3 、SR 4 、SR 5 、SR 6 、SR 7 、SR 8 、SR F0 、SR C0 :Filter,

[0092] TV 0 、TV 1 、TV 2 、TV 3 、TV 4 、TV 5 :Three-way valve,

[0093] FV 0 、FV 1 、FV 2 、FV 3 、FV 4 :Four-way valve,

[0...

Embodiment 3

[0105] Prepare 150 mL of ethanol solution containing liquid tangerine essential oil (ACDlogP=4.4) (33uL / mL) and Tween 80 (67uL / mL) at room temperature, and place it in the organic phase storage tank V FO1 ; 150mL water is placed in the water storage tank V FW1 , 400mL water is placed in the circulation storage tank V FW0 Using the same method as in Example 1, after turning on the power supply and running the pump to exhaust the air, ethanol solution, water, and circulating fluid are simultaneously pumped into each feed port of the CIJ-L mixer with a flow ratio of 1:1:8. When the liquid circulates in the circulating storage tank for 100, 200, and 300 seconds (corresponding to 1, 1.8, and 2.5 cycles respectively, and obtains 3.3, 5.6, and 7.1 μg / mL tangerine essential oil nanoemulsion), take a few samples each and use dynamic light scattering tracking to measure the dispersion. The liquid particle size is 1 week, and the preparation is completed after a cycle of 300 seconds. O...

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Abstract

The invention discloses a method and a device for preparing nanoscale dispersion liquid. A hydrophobic compound is dissolved into an organic solvent as an organic phase, the organic phase, as more than one strand of liquid, and more than one strand of a water phase flow in a jet manner in a multi-inlet mixer cavity for continuous mixing to obtain mixed liquid, the mixed liquid flowing out of the cavity is continuously and circularly flown in the jet manner to return into the multi-inlet mixer cavity, and is then mixed with the organic phase and the water phase again, and the mixed liquid flowsout of a multi-inlet mixer until dispersion liquid with preset concentration is obtained, so that the nanoscale dispersion liquid is obtained. Nanoscale particles are quickly mixed and formed insidethe cavity once, the process of secondary particle formation caused by the fact that secondary attenuation mixing further needs to be carried out with a hydrophilic phase after flowing out of the cavity is avoided, and the particle size, distribution and stability of the dispersion liquid are improved; sufficiently large proportion water content and degree of supersaturation can be provided duringmixing through the application of recycle mixing, instantly uniform formation of particles is guaranteed, and meanwhile, the dispersion liquid is avoided from being excessively diluted due to an overlarge water proportion.

Description

technical field [0001] The invention relates to a method and device for preparing a nanoscale dispersion liquid, belonging to the field of nanomaterial preparation. Background technique [0002] Nanoscale dispersions such as nanoemulsions and nanosuspensions have large specific surface areas due to their small size, and exhibit excellent properties in terms of dissolution rate, viscosity, transparency, utility, and stability. It is widely used in medicine, food, mechanical processing, construction, printing and dyeing, petrochemical, daily chemical and other industries, and the demand is huge. Nanoemulsion is a multi-phase dispersion system formed by dispersing nano-droplets in another immiscible liquid, while suspension is a multi-phase dispersion system formed by dispersing nano-solid particles in a liquid . The conventional preparation methods of nanoemulsions and nanosuspensions: mechanical ball milling, high-pressure homogenization, and drop stirring methods have the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/08B01F5/02B01F5/10
CPCB01F23/45B01F25/20B01F25/50
Inventor 朱正曦王晓晓
Owner YANGZHOU UNIV
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