Aryl ruthenium complex with antitumor activity as well as preparation method and application of aryl ruthenium complex

A technology of anti-tumor activity and aryl ruthenium, which is applied to medical preparations of non-active ingredients, anti-tumor drugs, pharmaceutical formulations, etc., to achieve the effects of reducing raw material loss, simple preparation method, and good biological activity

Inactive Publication Date: 2018-11-13
GUANGXI TEACHERS EDUCATION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors

Method used

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  • Aryl ruthenium complex with antitumor activity as well as preparation method and application of aryl ruthenium complex
  • Aryl ruthenium complex with antitumor activity as well as preparation method and application of aryl ruthenium complex
  • Aryl ruthenium complex with antitumor activity as well as preparation method and application of aryl ruthenium complex

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Experimental program
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preparation example Construction

[0037] 1) Preparation of small polypeptide molecules: select amino acid-king resin as the carrier (resin), fully swell the resin with dichloromethane, wash several times with dimethylformamide, and use DBLK (volume ratio piperidine:DMF=1: 4), remove the Fmoc-protecting group (Fmoc is 9-fluorenylmethoxycarbonyl, which can be used as an amino protecting group), then wash several times with dimethylformamide, wash away DBLK, and weigh a suitable condensing agent Benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate and the activator methylmorpholine and the second Fmoc-protected amino acid at the C-terminus (Fmoc-Pro-OH) were used for coupling The connection is detected by the ninhydrin detection method to ensure that the connection is relatively complete, washed several times with dimethylformamide to wash away the remaining residues, activators and condensation agents, coupled according to the amino acid sequence, and all the After the amino acid connection is complete...

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Abstract

The invention discloses an aryl ruthenium complex with antitumor activity. The structural formula (I) of the aryl ruthenium complex is shown in the description. The aryl ruthenium complex provided bythe invention has stronger antitumor activity and a good application prospect of being developed into drugs for treating gastric cancer, liver cancer and other diseases.

Description

technical field [0001] The present invention relates to the technical field of metal complexes. More specifically, the present invention relates to aryl ruthenium complexes with antitumor activity, their preparation methods and applications. Background technique [0002] Malignant tumor has a high fatality rate and is one of the most important diseases that endanger human health. So far, there is still no effective treatment. Most of the anti-tumor drugs in clinical application belong to nucleoside drugs. These drugs have similar anti-tumor spectrum and have strong toxic and side effects. On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, and tumor cell lines are also prone to mutation. Therefore, the development of anti-tumor drugs that can overcome drug resistance or have broad-spectrum activity has attracted attention. The anti-tumor spectrum and anti-tumor mechanism of metal complexes are different from those of nucleoside d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61K31/555A61K9/00A61K47/32A61P35/00A61P9/12A61P21/04
CPCA61K9/0024A61K47/32A61P9/12A61P21/04A61P35/00C07F15/0046
Inventor 苏炜彭炳华
Owner GUANGXI TEACHERS EDUCATION UNIV
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