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Freeze-drying powder for fluorouracil composition for injection
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A technology of freeze-dried powder and fluorouracil, which is applied in the field of fluorouracil preparations and achieves the effects of good inhibition effect, high stability and long storage time
Active Publication Date: 2018-11-23
海南卓泰制药有限公司
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But no one has used it for the preparation of antitumor drugs
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Embodiment 1
[0039] A fluorouracil composition freeze-dried powder for injection, which comprises 80g of fluorouracil, 12g of sodiumhydroxide, and 10g of yam polysaccharide;
[0040] The preparation method of described yam polysaccharide comprises the steps:
[0041] 1) Peel the yam, protect the color, crush it, add water 8 times the mass of the yam, and decoct twice for 3 hours each time, filter and combine the filtrate, and concentrate the obtained filtrate to a relative density of 1.2 at 25°C thick paste;
[0042] 2) Add water equivalent to 20 times the quality of the thick paste in step 1) for dilution, then add ethanol with a concentration of 95% for precipitation, the amount of ethanol is 8% of the thick paste quality, filter, and take the supernatant , concentrated, and finally dried at 65°C for 8h;
[0043] The preparation method of described freeze-dried powder comprises the steps:
[0044] S1 Take 50% of the yam polysaccharide and add water equivalent to 5 times its mass to d...
Embodiment 2
[0052] A fluorouracil composition freeze-dried powder for injection, which includes 80g of fluorouracil, 12g of sodiumhydroxide, and 80g of yam polysaccharide;
[0053] The preparation method of described Chinese yam polysaccharide is with embodiment 1;
[0054] The preparation method of the freeze-dried powder is the same as in Example 1.
Embodiment 3
[0056] A fluorouracil composition freeze-dried powder for injection, which includes 80g of fluorouracil, 12g of sodiumhydroxide, and 3g of yam polysaccharide;
[0057] The preparation method of described Chinese yam polysaccharide is with embodiment 1;
[0058] The preparation method of the freeze-dried powder is the same as in Example 1.
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Abstract
The invention belongs to the technical field of preparation of a fluorouracil preparation, and particularly relates to a freeze-dryingpowder for a fluorouracil composition for injection. The freeze-dryingpowder comprises fluorouracil, a pH (potential of hydrogen) value regulator and Chinese yam polysaccharide. The freeze-dryingpowder for the fluorouracil composition for injection has the advantages that the stability is high, the storage time is long, and the good inhibiting effect is realized on tumors.
Description
technical field [0001] The invention belongs to the technical field of fluorouracil preparations, in particular to a freeze-dried powder of a fluorouracil composition for injection. Background technique [0002] Fluorouracil is a broad-spectrum antitumor drug discovered in the 1950s. It can interfere with the nucleic acidmetabolism of tumor cells through various pathways and metabolites. Nucleotides are metabolites with anti-tumor activity. They can be covalently combined with reduced tetrahydrofolate and thymine nucleotides and synthetic bacterial enzymes (Ts) to form a ternary complex to inactivate TS enzymes, thereby Inhibits DNA synthesis. Fluorouracil has clinical inhibitory effect on a variety of tumors, and can treat gastric cancer, liver cancer, pancreatic cancer, breast cancer, ovarian cancer, choriocarcinoma, malignant mole, bladder cancer, lungcancer, skincancer, head and neck cancer, etc. In recent years, there have also been many combination regimens contai...
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