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Platinum-silver nano-cluster protected by erlotinib and preparation method thereof

A technology of erlotinib and nano-clusters, applied in the field of erlotinib-protected platinum-silver nano-clusters and its preparation, which can solve the problems of lack of light-emitting functional structure design and blankness, and achieve excellent luminescent performance and low preparation cost , the effect of high yield

Inactive Publication Date: 2018-11-23
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this research has just started, and is only in the preliminary stage of case synthesis, structural characterization, and performance research. It lacks luminescent function-oriented structural design, especially for its design research in the field of luminescent sensing biomedical analysis applications.

Method used

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  • Platinum-silver nano-cluster protected by erlotinib and preparation method thereof
  • Platinum-silver nano-cluster protected by erlotinib and preparation method thereof
  • Platinum-silver nano-cluster protected by erlotinib and preparation method thereof

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Experimental program
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Embodiment 1

[0019] 0.1 mmol of Pt(tht) 2 Cl 2 and 0.8 mmol [Ag(Erlotinib)] n Mix and dissolve in 6 mL of dichloromethane and 3 mL of methanol mixed solvent, stir and react at room temperature for 2 hours under anaerobic conditions to obtain a yellow clear solution, and then add 0.2 mmol of NaBH dropwise 4 methanol solution, the solution changed from yellow clear to reddish-brown turbid, anaerobic and stirred at room temperature for 24 hours, spin-dried after the reaction was completed, dissolved in dichloromethane, centrifuged, dissolved in dichloromethane and spin-dried with After repeated washing with ether, recrystallization with chloroform-ether gave reddish-brown platinum-silver nanoclusters [PtAg 12 (Erlotinib) 8 ] Cl 6 .

[0020] nanocluster [PtAg 12 (Erlotinib) 8 ] Cl 6 Chemical formula: PtAg 12 C 176 h 176 N 24 o 32 Cl 6 .

[0021] Elemental analysis [theoretical value (experimental value) (%)]: C: 43.66 (41.81); H: 3.66 (4.05); N: 6.94 (6.91).

[0022] ICP analys...

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Abstract

The invention discloses a platinum-silver nano-cluster protected by erlotinib and a preparation method thereof. Erlotinib alkyne-silver polymers [Ag(Erlotinib)]n and Pt(tht)2Cl2 serve as precursors, CH2Cl2 and methyl alcohol serve as reaction solvents, the precursors and the reaction solvents are stirred and react for 2 hours at room temperature under the anaerobic condition, NaBH4 serves as a reducing agent to be stirred and react for 24 hours at room temperature under the anaerobic condition, chloroform and diethyl ether are subjected to recrystallization, and the platinum-silver alkyne nano-cluster [PtAg12(Erlotinib)8]Cl6 protected by erlotinib is obtained through synthesis. The preparation method is simple in technology, the reaction condition is mild, and the yield is high. The invented platinum-silver alkyne nano-cluster is unique in structure, the nano crystal grain size is small (approximately 2 nm), and the platinum-silver nano-cluster has the double luminosity in both of visible light region and near infrared light region, and has the huge potential at the aspects of visualized treatment of cancers and near infrared bioluminescence sensing.

Description

technical field [0001] The invention belongs to the technical field of luminescent sensing bioanalysis, and in particular relates to a platinum-silver nano-cluster protected by erlotinib and a preparation method thereof. Background technique [0002] Noble metal nanoclusters refer to molecular aggregates composed of several to hundreds of metal atoms such as gold, silver, and platinum whose radii are smaller than their electron Fermi wavelengths under the protection of a certain molecular layer. Noble metal nanoclusters not only have better optical properties such as good photostability, large Stotek shift, controllable emission wavelength in the visible and near-infrared regions, and two-photon absorption characteristics, but also have less toxicity and smaller size. , and it is not easy to self-polymerize, which makes it have great application prospects in biomedical analysis of luminescence sensing, and is becoming a research hotspot in many fields such as chemistry, bi...

Claims

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Application Information

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IPC IPC(8): C09K11/87C09K11/06A61K49/00A61P35/00B82Y30/00B82Y40/00
CPCA61K49/0019A61K49/0065A61P35/00B82Y30/00B82Y40/00C09K11/06C09K11/87C09K2211/185
Inventor 魏巧华马贤鉴林志香吴秀鑫
Owner FUZHOU UNIV